1. Kong XD, Li L, Chen S, Yuan S, Zhou J*, Xu JH* (2014). Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111 (44): 15717-15722.

‍‍http://www.pnas.org/content/111/44/15717‍‍

 

2. Kong XD, Ma Q, Zhou JH*, Zeng BB*, Xu JH* (2014). A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-b-blocker precursors.  Angew Chem Int Ed, 2014, 53: 6641 –6644. (Highlighted by Synfacts 2014, 10(8): 0866)

http://onlinelibrary.wiley.com/doi/10.1002/anie.201402653/abstract

 

3. Luo XJ, Kong XD, Zhao J, Chen Q, Zhou JH*, Xu JH* (2014). Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp. Biotechnology and Bioengineering, 111(10): 1920-1930.

http://onlinelibrary.wiley.com/doi/10.1002/bit.25272/abstract

 

4. Zhang Y, Pan J, Luan ZJ, Xu GC*, Xu JH*, Park SH (2014). Promiscuous esterase activity of a novel bacterial chloroperoxidase for highly enantioselective synthesis of a chiral cilastatin precursor. Appl Environ Microbiol, 80(23): 7348-7355.

http://aem.asm.org/content/80/23/7348

 

5. Zhang XY, Fan X, Qiu YJ, Li CY, Xing S, Zheng YT, Xu JH* (2014). A thermostable esterase newly identified from Sulfobacillus acidophilus: Properties and performance in phthalate esters degradation. Appl Environ Microbiol, 80(22), 6870-6878.

http://aem.asm.org/content/80/22/6870

6. Gong Y, Xu GC, Li CX*, Zheng GW, Xu JH* (2014). A thermostable variant of Bacillus subtilis esterase: characterization and application for resolving dl-menthyl acetate. J Mol Catal B: Enzym. 109: 1-8.

http://www.sciencedirect.com/science/article/pii/S138111771400215X

 

7. Chen RJ, Zheng GW*, Ni Y, Zeng BB, Xu JH* (2014). Efficient synthesis of a ε-hydroxy ester in a space-time yield of 1580 g/L/d by a newly identified reductase RhCR. Tetrahedron: Asymmetry, 25: 1501–1504.

http://www.sciencedirect.com/science/article/pii/S0957416614004303

 

8. Wu YW, Kong XD, Zhu QQ, Fan LQ*, Xu JH* (2014). Chemoenzymatic enantioconvergent hydrolysis of p-nitrostyrene oxide into (R)-p-nitrophenyl glycol by a newly cloned epoxide hydrolase VrEH2 from Vigna radiate. Catal. Commun., 58: 16-20.

http://www.sciencedirect.com/science/article/pii/S1566736714003240

 

9. Li SX *, Ma Q, Lin K, Wu JJ, Wu YX, Xu JH* (2014). Essential role of Gly33 in a novel organic solvent-tolerant ipase from Serratia marcescens ECU1010 as determined by site-directed mutagenesis. Appl Biochem Biotechnol, 172: 2945-2954.

http://link.springer.com/article/10.1007%2Fs12010-013-0690-4

10. He YC, Tao ZC, Zhang X, Yang ZX, Xu JH (2014). Highly efficient synthesis of ethyl (S)-4-chloro-3-hydroxybutanoate and its derivatives by a robust NADH-dependent reductase from E. coli CCZU-K14. Bioresource Technology 161: 461-464.

http://www.sciencedirect.com/science/article/pii/S0960852414004386

11. Liu XY, Li CX, Luo XJ, Lai QL, Xu JH* (2014). Burkholderia jiangsuensis sp. nov., a methyl parathion (MP)-degrading bacterium, isolated from MP-contaminated soil. Int J Syst Evol Microbiol, 64: 3247-3253.

http://ijs.sgmjournals.org/content/64/Pt_9/3247

12. Liu XY, Luo XJ, Li CX, Lai QL, Xu JH* (2014). Draft genome sequence of Burkholderia sp. strain MP-1, a methyl parathion (MP)-degrading bacterium from MP-contaminated soil. Genome Announcements, 2(3): e00344-14

http://genomea.asm.org/content/2/3/e00344-14

13. Du FL, Yu HL, Xu JH, Li CX* (2014). Enhanced limonene production by optimizing the expression of limonene biosynthesis and MEP pathway genes in E. coli Bioresources and Bioprocessing, 2014, 1: 10.

http://link.springer.com/article/10.1186/s40643-014-0010-z

14. Pan J, Dang ND, Zheng GW*, Bo Cheng, Ye Q, Xu JH* (2014).  Efficient production of l-menthol in a two-phase system with SDS using an immobilized Bacillus subtilis esterase. Bioresources and Bioprocessing, 2014, 1: 12.

http://link.springer.com/article/10.1186/s40643-014-0012-x

15. Pan J, Zheng GW, Ye Q, Xu JH* (2014). Optimization and scale-up of bioreduction process for cost-effective production of (S)-4-chloro-3-hydroxybutanoate. Organic Process Research and Development, 18: 739-743. (Highlighted by Synfacts 2014, 9: 987)

http://pubs.acs.org/doi/abs/10.1021/op500088w

16. Qian XL, Pan J, Shen ND, Ju X, Zhang J* and Xu JH* (2014). Efficient production of ethyl (R)-2-hydroxy-4-phenylbutyrate using an economically competitive reductase expressed in Pichia pastoris. Biochemical Engineering Journal, 91: 72-77.

http://www.sciencedirect.com/science/article/pii/S1369703X14002009

17. Zhang ZJ, Pan J, Li CX, Yu HL, Ju X, Xu JH* (2014). Efficient production of (R)-(-)-mandelic acid using glutaraldehyde cross-linked Escherichia coli cells expressing Alcaligenes sp. nitrilase. Bioprocess and Biosystems Engineering. 37: 1241–1248.

http://link.springer.com/article/10.1007%2Fs00449-013-1096-y

18. Liu JY, Zheng GW*, Imanaka T, and Xu JH* (2014). Stepwise and combinatorial optimization of enantioselectivity for asymmetric hydrolysis of 1-(3’,4’-methylene dioxyphenyl)ethyl acetate  using a cold-adapted Bacillus amyloliquefaciens esterase.  Biotechnology and Bioprocess Engineering. 19: 442-448.

http://link.springer.com/article/10.1007%2Fs12257-013-0559-y

19. Ni Y, Hagedoorn PL, Xu JH, Arends IWC E, Hollmann F* (2014). Pyrococcus furiosus-mediated reduction of conjugated carboxylic acids: towards using syngas as reductant. Journal of Molecular Catalysis B: Enzymatic, 103: 52–55.

http://www.sciencedirect.com/science/article/pii/S1381117713002567

20. Huang L, Ma HM, Yu HL*, Xu JH* (2014). Altering the substrate specificity of a reductase CgKR1 by protein engineering for bioreduction of aromatic a-ketoesters. Advanced Synthesis and Catalysis, 356: 1943–1948.

http://onlinelibrary.wiley.com/doi/10.1002/adsc.201300775/abstract

 

21. Dou S, Kong XD, Ma BD, Chen Q, Zhang J, Zhou JH*, Xu JH* (2014). Crystal structures of Pseudomonas putida esterase reveal the functional role of residues 187 and 287 in substrate binding and chiral recognition. Biochemical and Biophysical Research Communications, 446: 1145–1150.

http://www.sciencedirect.com/science/article/pii/S0006291X14005154

 

22. Yin YC, Yu HL*, Luan ZJ, Li RJ, Ouyang PF, Liu J, Xu JH (2014). Unusually broad substrate profile of a self-sufficient cytochrome P450 monooxygenase CYP116B4 mined from Labrenzia aggregate. ChemBioChem, 15 (16): 2443-2449. 

http://onlinelibrary.wiley.com/doi/10.1002/cbic.201402309/abstract

 

23. Xu YP, Yu HL*, Guan YH, Ni Y, Ma BD, Xu JH* (2014). Significantly improved methyl o-chlorobenzoylformate bioreduction by stabilizing aldo-keto reductase YtbE with additives chosen based on inactivation mechanism elucidation. Journal of Molecular Catalysis B: Enzymatic, 104: 108–114.

http://www.sciencedirect.com/science/article/pii/S138111771400071X

24. Li J, Pan J, Zhang J*, Xu JH* (2014). Stereoselective synthesis of L-tert-leucine by a newly cloned leucine dehydrogenase from Exiguobacterium sibiricum. Journal of Molecular Catalysis B: Enzymatic, 105: 11–17.

http://www.sciencedirect.com/science/article/pii/S1381117714000757

25. Ma BD, Kong XD, Yu HL*, Zhang ZJ, Dou S, Xu YP, Ni Y, Xu JH* (2014). Increased catalyst productivity in α-hydroxy acids resolution by esterase mutation and substrate modification.  ACS Catalysis, 4: 1026-1031.

http://pubs.acs.org/doi/abs/10.1021/cs401183e

 

26. Nguyen-Tran HH, Zheng GW*, Qian XH and Xu JH* (2014). Highly selective and controllable synthesis of arylhydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitroreductase BaNTR1. Chemical Communications, 50: 2861-2864.

http://pubs.rsc.org/en/Content/ArticleLanding/2014/CC/c3cc48590k

 

27. Ni Y, Yu HL, Lin GQ, Xu JH* (2014). A new ene reductase from Clavispora lusitaniae for asymmetric reduction of activated alkenes. Enzyme and Microbial Technology, 56: 40–45.

http://www.sciencedirect.com/science/article/pii/S0141022914000027

28. Zhu QQ, He WH, Kong XD, Fan LQ*, Zhao J, Li SX, Xu JH* (2014). Heterologous overexpression of Vigna radiata epoxide hydrolase in Escherichia coli and its catalytic performance in enantioconvergent hydrolysis of p-nitrostyrene oxide into (R)-p-nitrophenyl glycol. Applied Microbiology and Biotechnology, 98: 207-218.

http://link.springer.com/article/10.1007%2Fs00253-013-4845-6

29. Zhou WJ, Ni Y, Zhu ZR, Zheng GW*, Chen HH, Zhu ZR and Xu JH* (2014). Enzymatic resolution of a chiral chlorohydrin precursor for (R)-α-lipoic acid synthesis via lipase catalyzed enantioselective transacylation with vinyl acetate. Journal of Molecular Catalysis B: Enzymatic, 99: 102-107.

http://www.sciencedirect.com/science/article/pii/S1381117713003342

30. Hu K, Li CX*, Pan J, Ni Y, Zhang XY, Xu JH* (2014). Performance of a new thermostable mannanase in breaking guar-based fracturing fluids at high temperatures with little premature degradation. Applied Biochemistry and Biotechnology, 172(3): 1215-1226.

http://link.springer.com/article/10.1007%2Fs12010-013-0484-8

31. Yan Ni, Hui-Lei Yu and Jian-He Xu (2014).  Solvent effects in bioreductions. Chapter 9, in: Synthetic Methods for Biologically Active Molecules, ed. E. Brenna, Wiley-VCH, 2014, Weinheim.