| Education： |
| 2003.09 – 2008.04 Ph.D. in Biochemical Engineering (Prof. Jian-He Xu Group) East China University of Science and Technology (ECUST) |
| Academic Positions： |
| 2005.09 – 2007.04 Visiting Researcher in Prof. Guo-Qiang Lin Group, Shanghai Institute of Organic Chemistry, Chinese Academic of Sciences |
| 2008.04 – 2010.09 Assistant Professor, Lab of Biocatalysis and Bioprocessing, State Key Laboratory of Bioreactor Engineering, ECUST |
| 2010.09 – Present Associate Professor, Lab of Biocatalysis and Bioprocessing, State Key Laboratory of Bioreactor Engineering, ECUST |
| 2012.08Visiting Researcher in Prof. T Imanaka Group Ritsumeikan University, Japan |
| 2013.06 – 2014.06 Visiting Professor in Bioinformatics & Metabolic Engineering Laboratory (Prof. Gregory Stephanopoulos’ Group) Massachusetts Institute of Technology, USA |
|
| Research： |
| Genomic mining and evolution of oxidoreductase |
| Multi-enzymatic reaction for combinatorial biocatalysis |
| Biocatalytic Synthesis and/or Resolution of Chiral Compounds |
| Publication： |
| Journal papers： |
| 1. Yin YC, Yu HL*, Luan ZJ, Li RJ, Ouyang PF, Liu J, Xu JH. Unusually broad substrate profile of a self-sufficient cytochrome P450 monooxygenase CYP116B4 mined from Labrenzia aggregate. ChemBioChem 2014, 25(16): 2443-2449 |
| 2. Huang L, Ma HM, Yu HL* and Xu JH*. Altering the substrate specificity of a reductase CgKR1 from Candida glabrata by protein engineering for bioreduction of aromatic α-keto esters. Adv.Synth.Catal. 2014, 356(9): 1943-1948. |
| 3. Xu YP, Guan Y H, Yu HL*, Ni Y, Ma BD, Xu JH*. Improved o-chlorobenzoylformate bioreduction by stabilizing aldo-keto reductase YtbE with additives. J Mol Catal B: Enzymatic 2014, 104: 108-114. |
| 4. 4.Ma BD, Kong XD, Yu HL*, Zhang ZJ, Dou S, Xu YP, Ni Y, and Xu JH *. Increased Catalyst Productivity in α-Hydroxy Acids Resolution by Esterase Mutation and Substrate Modification. ACS Catal. 2014, 4 (3): 1026–1031. |
| 5. Zhang WX, Xu GC, Huang L, Pan J, Yu HL*, Xu JH*. Highly efficient synthesis of (R)-3-quinuclidinol in a space–time yield of 916 g L–1 d–1 using a new bacterial reductase ArQR. Org. Lett. 2013, 15(19): 4917–4919. |
| 6. Xu GC, Yu HL*, Zhang ZJ, Xu JH*. Stereocomplementary bioreduction of β-ketonitrile without ethylated byproduct. Org. Lett. 2013, 15(21): 5408–5411. |
| 7. Ma BD, Yu HL*, Pan J, Liu JY, Ju X, Xu JH*.A thermostable and organic-solvent tolerant esterase from Pseudomonas putida ECU1011: Catalytic properties and performance in kinetic resolution of alpha-hydroxy acids. Bioresour. Technol. 2013, 133: 354-360. |
| 8. Xu GC, Yu HL*, Zhang XY and Xu JH*. Access to optically active aryl halohydrins using a substrate-tolerant carbonyl reductase discovered from Kluyveromyces thermotolerans. ACS Catal. 2012, 2(12): 2566–2571. |
| 9. Zou ZZ, Yu HL*, Li CX, Zhou XW, Hayashi C, Sun J, Liu BH, Imanaka T, Xu JH*. A new thermostable beta-glucosidase mined from Dictyoglomus thermophilum: Properties and performance in octyl glucoside synthesis at high temperatures. Bioresour. Technol. 2012, 118: 425-430. |
| 10. Yu HL, Ou L, Xu JH*. New trends in non-aqueous biocatalysis. Curr. Org. Chem. 2010, 14(14): 1424-1432. |
| 11.Yu HL, Xu JH*, Lu WY, Lin GQ. Discovery and utilization of biocatalysts for chiral synthesis: An overview of Chinese scientists research and development. Adv. Biochem. Eng. Biotechnol. 2009, 113: 1-31 |
| 12.Yu HL, Xu JH*, Lu WY, Lin GQ. Environmentally benign synthesis of natural glycosides using apple seed meal as green and robust biocatalyst. J. Biotechnol. 2008, 133: 469-477 |
| 13.Yu HL, Xu JH*, Wang YX, Lu WY, Lin GQ. Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media. J. Comb. Chem. 2008, 10: 79-87 |
| Conference paper： |
| Monographs |
| 郁惠蕾, 许建和 译校 (许建和、陶军华、林国强 主译). 面向制药工业的生物催化—发现、开发及生产. 化学工业出版社. 2010奖(图书奖)一等奖。 |
| 许建和, 郁惠蕾. 生物催化法合成手性药物及中间体. 见：林国强、王梅祥 主编，《手性合成与手性药物》(第2章). 化学工业出版社. 2008 |
| Achievement： |
| Funding： |
| 973子课题、2011CB710805、多酶反应模块的设计及模块组装过程调控、 2011.01-2015.06、在研、主持。 |
| 863课题、手性环氧丙酸酯的化学-酶法合成技术、2011AA02A210、 2011.01-2015.12、在研、参与。 |
| 霍英东基金、132031、基于基因组信息的新型微生物催化剂发现及应用， 2012/01-2014/12、已结题、主持。 |
| 国家自然科学基金青年项目、20902023、新型单加氧酶的筛选、性能及用于 C-H键活化和药物分子组合衍生的研究、2010/01-2012/12、19万元、已结题、主持。 |
| Patent: |
| 1. 马宏敏、李春秀、潘江、郑高伟、郁惠蕾、许建和. 一种羰基还原酶、基因和突变体及在不对称还原羰基化合物中的应用. ZL 201210136823.8 |
| 2. 许建和、许国超、郁惠蕾. 一种羰基还原酶、基因及其在不对称还原前手性羰基化合物中的应用. ZL 201210423006.0. |
| 3. 郁惠蕾、张文霞、潘江、许建和. 一种奎宁酮还原酶及其在不对称合成(R)-3-奎宁醇中的应用. CN103555608A. |
| 4.郁惠蕾、黄磊、许建和、李春秀、潘江. 一种羰基还原酶突变体及其基因和应用 201410345443.4. |
| Award: |
| 2010年获优秀百篇博士论文提名奖。00780038340.1 |
| 2012年获霍英东基金资助。 |
| 2014年荣获亚洲青年化学工程师大会最佳墙报奖(每地区2人)。14-10-01. |
| 2014年入选华东理工大学大学青年英才计划(全校20人)。 |