SKLBE学术论坛
发布时间:2020-11-20 10:11:00
题目:Engineering Biology: programming cells to compute, sense and manufacture
报告人:英国爱丁堡大学 王宝俊 教授
时间:2020-11-25 (周三) 13:30-
地点:实验18楼315室
主持人:叶邦策教授
BAOJUN WANG, Ph.D.
G20 Roger Land, School of Biological Sciences, University of Edinburgh, EH9 3FF baojun.wang@ed.ac.uk
Career and Research Experience
08/2019 – Present Reader in Synthetic Biology, School of Biological Sciences, University of Edinburgh
05/2019 – present UK Research and Innovation Future Leaders Fellow, School of Biological Sciences, University of Edinburgh
07/2013 – 07/2019 Group Leader & Chancellor’s Fellow in Synthetic Biology, University of Edinburgh
04/2011 – 07/2013 Research Associate in Synthetic Biology, Imperial College London
01/2007 – 03/2011 Ph.D. in Bioengineering (synthetic biology), Imperial College London
Education
01/2007 – 01/2011 Ph.D., Department of Bioengineering, Imperial College London, UK
09/2005 – 11/2006 MSc Diploma in Biomedical Engineering, Zhejiang University, China
09/2000 – 06/2005 B.Eng. in Biomedical Engineering, 1st class, Zhejiang University, China
Research Areas and Interests
Synthetic Biology and Bioengineering: Synthetic biology enabling tools; Biological circuit design and engineering; Cell-based/cell-free biosensors for toxins and pathogens; Engineered phage therapeutics for enteric infectious diseases. (Lab:http://wang.bio.ed.ac.uk/)
Selected Publications (* indicates corresponding author)
Wan X, Pinto F, Yu L and Wang B*, “Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity”, Nature Communications, 2020. doi pdf
Pinto F, Thornton E and Wang B*, “An expanded library of orthogonal split inteins enables modular multi-peptide assemblies”, Nature Communications, 2020, 11, 1529 doi
Hicks M, Bachmann T and Wang B*, “Synthetic biology enables programmable cell-based biosensors”, ChemPhysChem, 2020, 21, 132–144 doi (Featured as Front Cover Article)
Wan X, Volpetti F, Petrova E, French C, Maerkel SJ and Wang B*, “Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals”, Nature Chemical Biology, 2019, 15(5), 540–548 doi
Liu Y, Wan X and Wang B*, “Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria”,Nature Communications, 2019, 10, 3693 doi
Lopreside A, Wan X, Michelini E, Roda A and Wang B*, “Comprehensive profiling of diverse genetic reporters with application to whole-cell and cell-free biosensors”, Analytical Chemistry, 2019, 91, 15284?15292 doi
Liu Q, Schumacher J, Wan X, Lou C and Wang B*, “Orthogonality and burdens of heterologous AND gate gene circuits in E. coli, ACS Synthetic Biology, 2018, 7(2):553-564 doi
Bradley R, Buck M and Wang B*, “Tools and principles for microbial gene circuit engineering”, Journal of Molecular Biology, 2016, 428(5):862-888 doi
Bradley R, Buck M and Wang B*, “Recognizing and engineering digital-like logic gates and switches in gene regulatory networks”, Current Opinion in Microbiology, 2016, 33:74–82 doi
Wang B*, Barahona M and Buck M, “Amplification of small molecule-inducible gene expression via tuning of intracellular receptor densities”, Nucleic Acids Research, 2015, 43(3):1955-1964 doi
Wang B*, Barahona M and Buck M, “Engineering modular and tunable genetic amplifiers for scaling transcriptional signals in cascaded gene networks”, Nucleic Acids Research, 2014, 42(14): 9484-9492
doi (Reported by Imperial College Science News)
Wang B* and Buck M, “Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules”, Chemical Communications, 2014, 50(79):11642-44 doi (Front Cover Article)
Wang B*, Barahona M and Buck M, “A modular cell-based biosensor using engineered genetic logic circuits to detect and integrate multiple environmental signals”, Biosensors and Bioelectronics, 2013, 40, 368-376 doi
Wang B* and Buck M, “Customizing cell signaling using engineered genetic logic circuits”, Trends in Microbiology, 2012, 20(8): 376-384 doi
Wang B, Kitney R, Joly N and Buck M, “Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology”, Nature Communications, 2011, 2:508 doi
Selected Prizes and Awards
2020 Elected Fellow of the Royal Society of Chemistry (FRSC), Royal Society of Chemistry
2019 UKRI Future Leaders Fellowship, UK Research and Innovation
2017 SB7.0 Biosecurity Fellowship, The BioBricks Foundation, USA
2016 BBSRC New Investigator Award, Biotechnology and Biological Sciences Research Council
2016 Wellcome Seed Award in Science, Wellcome Trust
2015 Grand Challenges Explorations Award, Bill and Melinda Gates Foundation
2013 Chancellor’s Fellowship in Synthetic Biology, The University of Edinburgh
Selected Current/Related Research Grants
05/2019 – 05/2023 PI of UKRI Future Leaders Fellowship award (£1.56 million, MR/S018875/1)
Project: Engineering orthogonal split inteins as scalable tools for synthetic biology & biomanufacturing
01/2021 – 12/2023 PI of Leverhulme Trust research project grant (£360k, RPG-2020-241)
Project: Distributed cell-consortia biocomputers with scalable signal processing capacity
09/2020 – 09/2023 PI of US Office of Naval Research Global grant award ($390k, N62909-20-1-2036)
Project: 3D printed wearable biosensors for noninvasive sweat-based health monitoring
07/2016 – 06/2019 PI of BBSRC New Investigator award (BB/N007212/1, £433k)
Project: Enabling synthetic biology with an expanded library of engineered orthogonal genetic switches
Selected Invited Oral Presentations
11/2020 ‘The Future of Intelligent Sensing and Measurement’ Symposium, University of Glasgow
09/2020 Biological and Physiological Monitoring and Modeling Program 2020 Review Meeting, ONRG
11/2019 Warwick Integrative Synthetic Biology Centre Seminar, University of Warwick
09/2019 NII Shonan Meeting on "Formal methods for the synthesis of biomolecular circuits", Japan
05/2019 DSTL Synthetic Biology Showcase Conference, Williams F1 Conference Centre, Oxford
11/2018 Synthetic Biology UK 2018 Congress, London, organized by Oxford Global
06/2018 Biosensors 2018 – 28th Anniversary World Congress on Biosensors (950+ attendees), Miami,
06/2017 UK Centre for Doctoral Training in Synthetic Biology Conference, University of Oxford
03/2017 Contributing solutions to a global crisis: Launch of the Edinburgh AMR Strategy, Edinburgh
09/2016 Unlocking the potential of synthetic biology to enhance human health, London
07/2016 Society of Experimental Biology Annual Main Meeting, Brighton
05/2016 Biosensors 2016 – 14th World Congress on Biosensors (1200+ attendees), Gothenburg.
07/2014 16th European Congress on Biotechnology (800+ attendees), Edinburgh, organized by EFB.
05/2012 Keynote talk at Biosensors 2012 World Congress on Biosensors (700+ attendees), Cancun.
05/2010 Keynote talk at Biosensors 2010 World Congress on Biosensors (1000+ attendees), Glasgow.