魏东芝 教授

魏东芝 教授, 博士生导师 1984  B.S., East China University of Science & Technology, China 1989  Ph.D., East China University of Science & Technology, China 1989-1995   Lecture/Associate Professor, East China University of Science & Technology, China 1995-           Professor, East China University of Science & Technology, China 1992-1995   Deputy Director, Institute of Biochemical Engineering, East China University of Science &    Technology 1995-2001   Director, Institute of Biochemistry, East China University of Science & Technology 2001-2007   Dean, College of Biotechnology, East China University of Science & Technology 2001-           Director, New World Institute of Biotechnology, East China University of Science & Technology

魏东芝  国家重点学科-生物化工学科带头人，上海市重点学科-生物工程学科带头人，曾获“全国优秀科技工作者”，教育部跨世纪优秀人才、上海市科技领军人才，上海市优秀学科带头人, 中国科学院“百人计划”入选者，山东省“泰山学者”， 山东省“泰山产业领军人才”。从事酶学与生物催化研究，已发表学术论文200余篇，他引6500余次，获授权中国发明专利45项，实审国际专利3项(已覆盖美国、欧洲和日本等)，其中12项专利获得应用。魏教授于1998年自建科研大楼、创建产学研联合体、开拓科研成果产业化新模式；工业酶制剂、手性氨基酸、甾体药物及多元醇等项目在12家企业实现产业化（受益企业50多家）,创新增产值超过70亿，新增利税超过13亿，出口创汇约3.5亿美元；在科学技术促进产业化工作方面成绩突出，曾获国家技术发明二等奖1项，上海市技术发明及科技进步一等奖3项，第十五届国际工业博览会铜奖1项，中国石油化工联合会技术发明奖二等奖1项。

Research Interests

The long-term goal of his research is to develop novel enzyme, biocatalyst and cell factory facing to bioproducts, including enzyme engineering and synthetic biology.

ØDeveloping new methods for enzyme  engineering

Selected Publications

1. Tao XY, et al., Wei DZ*. Design and evaluation of a phospholipase D based drug delivery strategy of novel phosphatidyl-prodrug. Biomaterials. 2017, 131 1-14.

2. Gao X, et al., Wei DZ*. Construction of a reusable multi-enzyme supramolecular device via disulfide bond locking, Chemical Communications, 2015, 51, 10131—10133.

3. Zhu S, et al., Wei DZ*. Efficient hydration of 2-amino-2, 3-dimethylbutyronitrile to 2-amino-2, 3-dimethylbutyramide in a biphasic system via an easily prepared whole-cell biocatalyst, Green Chemistry, 2015, 17, 3992-3999. 

4. Gao X, et al., Wei DZ*. Artificial multienzyme supramolecular device: highlyordered self-assembly of oligomeric enzymes in vitro and in vivo, Angewandte Chemie, 2014, 126(51):14251-14254.

5. Yao K, et al., Wei DZ*. Characterization and engineering of 3-ketosteroid-Delta(1)-dehydrogenase and 3-ketosteroid-9 alpha-hydroxylase in Mycobacterium neoaurum ATCC 25795 to produce 9 alpha-hydroxy-4-androstene-3,17-dione through the catabolism of sterols, Metabolic Engineering, 2014, 24:181-191.