Gao-Wei Zheng



	Name: Gao-Wei Zheng
	Title: Professor
	Phone: +86-21-64250840
	Fax: +86-21-64250840
	Email: gaoweizheng@ecust.edu.cn

Education:

2005.09-2010.08 Ph.D. in Biochemical engineering, ECUST, Shanghai, China

2001.09-2005.07 B.S. in Bioengineering, Sichuan University, Chengdu, Sichuan, China

Academic Positions：

‍

2019.09-present Professor, State Key Laboratory of Bioreactor Engineering, ECUST, China

2013.09-2019.08 Associate professor, State Key Laboratory of Bioreactor Engineering, ECUST, China

2015.09-2016.09 Visiting academic, MIB, University of Manchester, Nicholas J. Turner, UK

2010.09-2013.08 Assistant professor, State Key Laboratory of Bioreactor Engineering, ECUST, China

Research：

Development of novel enzymes or creation of tailor-made enzymes in organic synthesis

Biocatalytic cascade reactions

Publication：

1. Fei-Fei Chen, Sebastian C. Cosgrove, William R. Birmingham, Juan Mangas-Sanchez, Joan Citoler, Matthew P. Thompson, Gao-Wei Zheng,* Jian-He Xu,* Nicholas J. Turner*. Enantioselective Synthesis of Chiral Vicinal Amino Alcohols Using Amine Dehydrogenases. ACS Catal. 2019, 9, 11813–11818.

2. Xu-Min Gong, Zhen Qin, Fu-Long Li, Bu-Bing Zeng, Gao-Wei Zheng*, Jian-He Xu*. Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor. ACS Catal., 2019, 9, 147–153.

3. Fei-Fei Chen†, Gao-Wei Zheng†, Lei Liu, Hao Li, Qi Chen, Fu-Long Li, Chun-Xiu Li, and Jian-He Xu* Reshaping the Active Pocket of Amine Dehydrogenases for Asymmetric Synthesis of Bulky Aliphatic Amines. ACS Catal. 2018, 8, 2622−2628.

4. Gao-Wei Zheng*,#, Yan-Yan Liu#, Chen Q#, Lei Huang, Hui-Lei Yu, Wen-Yong Lou, Chun-Xiu Li, Yun-Peng Bai, Ai-Tao Li, Jian-He Xu*. Preparation of Structurally Diverse Chiral Alcohols by Engineering Ketoreductase CgKR1. ACS. Catal. 2017, 7(10): 7174–7181.

5. Zheng GW, Xu JH*. New opportunities for biocatalysis: driving the synthesis of chiral chemicals. Curr Opin Biotechnol 2011, 22: 784–792.

6. Nguyen-Tran HH, Zheng GW*, Qian XH and Xu JH*. Highly selective and controllable synthesis of arylhydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitroreductase BaNTR1. Chem Commun 2014, 50, 2861–2864.

7. Hao Li, Ping Tian, Jian-He Xu*, Gao-Wei Zheng*. Identification of an imine reductase for asymmetric reduction of bulky dihydroisoquinolines. Org. Lett. 2017, 19(12): 3151–3154.

8. Zheng GW, Yu HL, Zhang JD, Xu JH*. Enzymatic production of l-menthol by a high substrate concentration tolerable esterase from newly isolated Bacillus subtilis ECU0554. Adv Synth Catal 2009, 351: 405-414.

9. Hao Li, Zheng-Jiao Luan, Gao-Wei Zheng,* and Jian-He Xu*. Efficient Synthesis of Chiral Indolines using an Imine Reductase from Paenibacillus lactis. Advanced Synthesis & Catalysis, 2015, 357, 1692-1696.

10.Yu-Jun Zhang, Wen-Xia Zhang, Gao-Wei Zheng,* and Jian-He Xu*. Identification of an ε-Ketoester Reductase for Efficient Synthesis of (R)-α-Lipoic Acid Precursor. Advanced Synthesis & Catalysis, 2015, 357, 1697-1702.

Achievement：

Funding

National Natural Science Foundation of China (No. 31200050 & 21472045), Ministry of Science and Technology, P. R. China (Nos. 2011CB710806 & 2011AA02A210) and the Fundamental Research Funds for the Central Universities (22A201514043).