陈显军

发布时间：2020-06-18 17:06:00

博士，副研究员，硕士生导师。

2009年6月本科毕业于华东理工大学生物工程学院生物技术专业，获理学学士学位。2015年6月博士毕业于华东理工大学药学院化学生物技术与工程专业，获工学博士学位。2015年7月开始从事华东理工大学药学博士后研究。2018年6月受聘于华东理工大学药学院特聘副研究员。陈显军博士长期从事合成生物学、光遗传学、化学生物学等领域的新方法、新技术的开发与应用。迄今已在Nature Biotechnology, Nature Methods、Cell Research、Nucleic Acid Research、ACS Synthetic Biology等国际权威期刊发表SCI论文18篇，编写英文著作Curr Protoc Chem Biol 1个章节。已申请多项中国发明专利（授权2项）和国际PCT专利（分别授权2项美国和日本发明专利，1项欧洲发明专利）。主持包括国家自然科学基金面上项目、青年基金、上海市自然科学基金等多项基金，入选中国科协2019-2021届“青年人才托举工程项目“，2020年度上海市启明星计划项目。

研究方向

（1）开发新型光遗传技术时空精确调控活细胞RNA代谢；

（2）开发新型化学生物学方法实时动态监测活细胞RNA分子。

主要论文：

(1) Xinyu Hou, Chenting Shou, Muye He, Jiajun Xu, Yi Cheng, Zeting Yuan, Minbo Lan, Yuzheng Zhao, Yi Yang, Xianjun Chen*, Feng Gao*, A combination of LightOn gene expression system and tumor microenvironment-responsive nanoparticle delivery system for targeted breast cancer therapy. Acta Pharmaceutica Sinica B, 2020.

(2) Xie Li, Changcheng Zhang, Xiaopei Xu, Jun Miao, Jing Yao, Renmei Liu, Yuzheng Zhao, Xianjun Chen*, Yi Yang*. A single-component light sensor system allows highly tunable and direct activation of gene expression in bacterial cells. Nucleic acids research, 2020, e33.

(3) Jiajun Xu, Muye He, Xinyu Hou,Yan Wang,Chenting Shou, Xiaoran Cai, Zeting Yuan, Yu Yin, Minbo Lan, Kaiyan Lou, Yuzheng Zhao, Yi Yang, Xianjun Chen*, Feng Gao*, Safe and Efficacious Diphtheria Toxin-Based Treatment for Melanoma: Combination of a Light-On Gene-Expression System and Nanotechnology. Molecular pharmaceutics, 2020, 17 (1), 301-315.

(4) Xianjun Chen^#, Dasheng Zhang^#, Ni Su^#, Bingkun Bao, Xin Xie, Fangting Zuo, Lipeng Yang, Hui Wang, Li Jiang, Qiuning Lin, Mengyue Fang, Ningfeng Li, Xin Hua, Zhengda Chen, Chunyan Bao, Jinjin Xu, Wenli Du, Lixin Zhang, Yuzheng Zhao, Linyong Zhu*, Joseph Loscalzo, Yi Yang*, Visualizing RNA Dynamics in Live Cells with Bright and Stable Fluorescent RNAs, Nature Biotechnology, 2019, 37: 1287-1293.

(5) Xiaopei Xu, Zhaoxia Du, Renmei Liu, Ting Li, Yuzheng Zhao, Xianjun Chen* and Yi Yang*, A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells, ACS Synthetic Biology, 2018, 7: 2045-2053.

(6) Yejun Zou , Aoxue Wang , Mei Shi , Xianjun Chen , Renmei Liu , Ting Li , Chenxia Zhang , Zhuo Zhang , Linyong Zhu , Zhenyu Ju , Joseph Loscalzo , Yi Yang*, Yuzheng Zhao*, Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors, Nature protocols, 2018, 13: 2362-2386..

(7) Rongkun Tao, Yuzheng Zhao, Huanyu Chu, Aoxue Wang, Jiahuan Zhu, Xianjun Chen, Yejun Zou, Mei Shi, Renmei Liu, Ni Su, Jiulin Du, Hai-Meng Zhou, Linyong Zhu, Xuhong Qian, Haiyan Liu*, Joseph Loscalzo, and Yi Yang*, Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism, Nature Methods, 2017, 14: 720-728.

(8) Hanyang Hu, Yanfang Gu, Lei Xu, Yejun Zou, Aoxue Wang, Rongkun Tao, Xianjun Chen, Yuzheng Zhao*, and Yi Yang*. A genetically encoded toolkit for tracking live-cell histidine dynamics in space and time, Scientific Reports, 2017, 7, 43479.

(9) Wansheng Sun, Wenyao Zhang, Chao Zhang, Miuwei Mao, Yuzheng Zhao, Xianjun Chen*, and Yi Yang*, Light-induced protein degradation in human-derived cells. Biochemical and Biophysical Research Communications, 2017, 487, 241-246.

(10 Xianjun Chen, Renmei Liu, Zhengcai Ma, Xiaopei Xu., Haoqian Zhang, Jianhe Xu, Qi Ouyang, and Yi Yang*, An extraordinary stringent and sensitive light-switchable gene expression system for bacterial cells, Cell Research, 2016, 26: 854-857. (IF=15.393)

(11) Xianjun Chen^#, Ting Li^#, Xue Wang, Zengmin Du, Renmei Liu, and Yi Yang*, Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light, Nucleic Acids Research, 2016, 44: 2677-2690.

(12) Xianjun Chen, Ting Li, Xue Wang, and Yi Yang*, A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes, Biochemical and Biophysical Research Communications, 2015, 465: 769-776.

(13) Yuzheng Zhao, Qingxun Hu, Feixiong Cheng, Ni Su, Aoxue Wang, Yejun Zou, Hanyang Hu, Xianjun Chen, Hai-Meng Zhou, Xinzhi Huang, Kai Yang, Qian Zhu, Xue Wang, Jing Yi, Linyong Zhu, Xuhong Qian, Lixin Chen, Yun Tang, Joseph Loscalzo, and Yi Yang*, SoNar, a Highly Responsive NAD(+)/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents, Cell Metabolism, 2015, 21: 777-789.

(14) Xue Wang, Xianjun Chen, and Yi Yang*, Spatiotemporal control of gene expression by a light-switchable transgene system, Nature Methods, 2012, 9: 266-269.

联系方式

地址：上海市徐汇区梅陇路130号318信箱邮编:200237

办公室：实验十八楼733室

电话/传真：021-64251287

E-mail: xianjunchen@ecust.edu.cn