第486次SKLBE学术论坛（德国勃兰登堡工业大学生物技术研究所所长, Jan-Heiner Küpper教授）

 题目：In vitro pharmacology and toxicology test systems using physiologically relevant human hepatocytes

报告人： 德国勃兰登堡工业大学生物技术研究所所长, Jan-Heiner Küpper教授

时间：  2019-9-12（星期四）10:00-11:30

地点：  实验18楼315室

主持人：  白云鹏 副教授

附Jan-Heiner Küpper教授介绍：

主要研究方向：微藻生物技术、毒理学、分子细胞生物学

教育背景：海德堡大学医学院博士、德国癌症研究中心博士后

学校职务：自2007年以来，任德国BTU Cottbus-Senftenberg分子细胞生物学教授

自2018年以来，任德国勃兰登堡健康校区健康科学学院理事会成员

2010-2016，任德国BTU Cottbus-Senftenberg生物技术研究所学院理事会成员

自2016年起，任德国BTU Cottbus-Senftenberg生物技术研究所所长

社会工作：多家科学期刊和资助机构的评审人

?  细胞生物技术杂志编辑委员会成员

?  德国细胞生物技术学会主席

Abstract

We have been developing a technology called Upcyting. This makes it possible to propagate human primary cells directly and efficiently in cell culture without using stem cells. A second approach is to “upgrade” liver cancer cell lines such as HepG2 with relevant enzymes involved in biotransformation. Our aim is to generate and use physiologically relevant human cells such as hepatocytes for basic cell biology research and drug testing, including cytotoxicity studies. An important research focus of our lab is the investigation of the activity of phase I and phase II enzymes in hepatocytes with particular regard to the formation of drug metabolites. We are also investigating potentially toxic effects of chemicals on human cell culture systems using in vitro toxicology readouts such as metabolic activity, apoptosis, FACS and double strand break formation (in case of drugs with genotoxicity). Please see also the review attached.