阳大海

研究方向：

1. 以模式动物小鼠、斑马鱼以及海水养殖动物大菱鲆为研究对象，采用多组学（单细胞测序、代谢组、表观遗传组）、基因编辑、反向遗传操作等技术手段，研究先天免疫细胞（巨噬细胞、中性粒细胞、血液细胞等）激活调控炎症性疾病发生分子机制；

2. 聚焦“先天免疫记忆”（训练免疫）这种新的免疫应答模式，解析其调控感染性器官损伤、系统性炎症疾病等关键分子靶标；并依托斑马鱼活体表型筛选平台、大菱鲆临床评价平台，开展靶向药物、免疫增强剂产品的活性评估及其作用机制研究。

主持项目：

1. 国家自然科学基金优秀青年科学基金项目，32122090，水产免疫生物学，2022.01-2024.12，200万元；

2. 上海市“科技创新行动计划”面上项目，20ZR1415500，鱼类焦亡信号调控中性粒细胞胞外陷阱功能研究，2020.02-2023.06，20万元；

3. 中国科协第二批“青年人才托举工程”，2016QNRC001，病原感染与免疫，2017.01-2019.06，45万元；

4. 国家自然科学基金青年项目，31602187，细菌类硫氧还蛋白调控MAPK信号通路及鱼类抗感染机制的研究，2017.01-2019.12，21万元；

5. 上海市“晨光计划” (A类)，16CG33，斑马鱼Caspase-A炎症小体激活介导的宿主免疫保护分子机制，2017.01-2019.12，6万元；

6. 上海市“浦江人才计划”，2016PJD020，细菌毒力因子“类硫氧还蛋白”抑制斑马鱼MAPK信号通路并调控细菌感染的机制研究，2016.01-2018.12，20万元。

代表性论文：

[1]. Weijie Chen#, Jianchang Huang#, Wei Wang#, Ying Wang#, Hao Chen, Qiyao Wang, Yuanxing Zhang, Qin Liu*,Dahai Yang*, Multi-tissue ScRNA-seq Reveals Immune Cell Landscape of Turbot (Scophthalmus maximus), Fundamental Research, 2022, in press.

[2]. Di Mu#, Jin Yang#, Yu Jiang#, Zhuang Wang, Weijie Chen, Jianchang Huang, Yuanxing Zhang, Qin Liu, Dahai Yang*, Single cell transcriptomic analysis reveals neutrophil as orchestrator during β-glucan-induced trained immunity in a teleost fish, The Journal of Immunology, 2022, in press.

[3]. Jiatiao Jiang, Wenwen Wang, Fei Sun, Yuanxing Zhang, Qin Liu, Dahai Yang*, Bacterial Infection Reinforces Host Metabolic Flux from Arginine to Spermine for NLRP3 Inflammasome Evasion, Cell Reports, 2021, 34(10):108832.

[4]. Weijie Chen, Jingjing Zhao, Di Mu, Zhuang Wang, Qin Liu, Yuanxing Zhang, Dahai Yang*, Pyroptosis Mediates Neutrophil Extracellular Trap Formation During Bacterial Infection in Zebrafish, The Journal of Immunology, 2021, 206(8):1913-1922.

[5]. Zhuang Wang, Zhaoyan Gu, Qing Hou, Weijie Chen, Di Mu, Yuanxing Zhang, Qin Liu, Zhihong Liu, Dahai Yang*, Zebrafish GSDMEb Cleavage-gated Pyroptosis Drives Septic Acute Kidney Injury In Vivo, The Journal of Immunology, 2020, 204(7): 1929-1942.

[6]. Ying Wen, Shouwen Chen, Zhiwei Jiang, Zhuang Wang, Jinchao Tan, Tianjian Hu, Qiyao Wang, Xiangshan Zhou, Yuanxing Zhang, Qin Liu, Dahai Yang*, Dysregulated Haemolysin Promotes Bacterial Outer Membrane Vesicles-Induced Pyroptotic-like Cell Death in Zebrafish, Cellular Microbiology, 2019, 21(6): e13010. (封面图片论文) 

[7]. Dahai Yang#, Xiaohong Liu#, Wenting Xu, Zhaoyan Gu, Cuiting Yang, Lingzhi Zhang, Jinchao Tan, Xin Zheng, Zhuang Wang, Shu Quan, Yuanxing Zhang, Qin Liu*, The Edwardsiella piscicida Thioredoxin-like Protein Inhibits ASK1-MAPKs Signaling Cascades to Promote Pathogenesis during Infection, PLoS Pathogens, 2019, 15(7): e1007917.

[8]. Dahai Yang, Xin Zheng, Shouwen Chen, Zhuang Wang, Wenting Xu, Jinchao Tan, Mingyu Hou, Wenhui Wang, Zhaoyan Gu, Qiyao Wang, Ruilin Zhang, Yuanxing Zhang, Qin Liu*, Sensing of Cytosolic LPS through Caspy2 Pyrin Domain Mediates Noncanonical Inflammasome Activation in Zebrafish, Nature Communications, 2018, 9(1): 3052.

[9]. Dahai Yang, Yuan He, Raul Muñoz-Planillo, Qin Liu*, Gabriel Núñez*, Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock, Immunity, 2015, 43(5): 923-932. (高被引论文)

联系方式：

地   址：上海市徐汇区梅陇路130号，阿华生物工程研究所101办公室

电   话：021-64253065

E-mail：dahaiyang@ecust.edu.cn