沈亚领

长期从事生物技术领域的研究工作，承担过国家级、省部级及横向课题项目20多项；在相关学科领域发表论文80多篇，其中Sci论文47篇，获授权发明专利11项，主持的产业化“凋亡素2配体（TRAIL）”（1.1类）项目完成Ⅰ、Ⅱ期和Ⅲ期临床研究；获省部级奖3次，出版译著两部，参编著作四部，指导的研究生论文三次获得上海市研究生优秀成果（学位论文）。

主要研究方向：

1. 生物化工/生物工程与技术/发酵工程：药用蛋白质/多肽/小分子产业化研发、靶向递药系统；生物下游过程；生物基化学品。

2. 微生物学：微生物群体效应及功能基因；微生物代谢工程和合成生物学；发酵生理。

近年主要论文：

1. Liaoyuan Zhang, Zewang Guo, Jiebo Chen, Quanming Xu, Hui Lin, Kaihui Hu, Xiong Guan & Yaling Shen*, Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241, Sci. Rep. 6, 19257; doi: 10.1038/srep19257 (2016)

2. Jiying Fan, Liying Huang, Jing Sun, Yi Qiu, Jinsong Zhou, Yaling Shen*, Strategy for linker selection to enhance refolding and bioactivity of VAS-TRAIL fusion protein based on inclusion body conformation and activity, Journal of Biotechnology, 2015, 209 , 16–22

3. Fangmin Bai, Lu Dai, Jiying Fan, Ngoctu Truong, Ben Rao,  Liaoyuan Zhang,  Yaling Shen*, Engineered Serratia marcescens for efficient (3R)-acetoin and (2R,3R)- 2,3-butanediol production, Journal of Industrial Microbiology and Biotechnology, 2015, 42(6), 779-786

4. Quanming Xu, Linxiang Xie, Yongyu Li, Hui Lin, Shujing Sun, Xiong Guan, Kaihui Hu, Yaling Shen*, Liaoyuan Zhang*, Metabolic engineering of Escherichia coli for efficient production of (3R)-acetoin, Journal of Chemical Technology and Biotechnology, 2015，90，93–100

5. Liaoyuan Zhang, Quanming Xu, Xiaoqian Peng, Boheng Xu, Yuehao Wu, Yulong Yang, Shujing Sun, Kaihui Hu, Yaling Shen*. Cloning, expression and characterization of glycerol dehydrogenase involved in 2,3-butanediol formation in Serratia marcescens H30. Journal of Industrial Microbiology and Biotechnology， 2014，41(9)，1319–1327

6. Liaoyuan Zhang*, Quanming Xu, Senran Zhan, Hui Lin, Shujing Sun, Li Sha,Xiong Guan, Kaihui Hu, Yaling Shen*，A new NAD(H)-dependent meso-2,3-butanediol dehydrogenase from an industrially potential strain Serratia marcescens H30，Applied Microbiology and Biotechnology，2014，98， 1175-1184

7. Jian-An Sun, Liao-Yuan Zhang, Ben Rao, Ya-Ling Shen* et al, Enhanced acetoin production by Serratia marcescens H32 with expression of a water-forming NADH oxidase，Bioresource Technology，2012，119，94-98

8. Jianan Sun, Ben Rao, Liaoyuan Zhang, Yaling Shen* et al, Extraction of acetoin from fermentation broth using an acetone/phosphate aqueous two-phase system, Chemical Engineering Communications，2012, 199（11）, 1492-1503

9. Jianan Sun，Liaoyuan Zhang, Ben Rao，Yaling Shen* et al，Enhanced acetoin production by Serratia marcescens H32 using statistical optimization and two-stage agitation speed control strategy，Biotechnology and Bioprocess Engineering，2012，17（3），598-605

10. Ben Rao，Liao Yuan Zhang，Jian’an Sun，Yaling Shen* et al，Characterization and regulation of the 2,3-butanediol pathway in Serratia marcescens，Applied Microbiology and Biotechnology，2012，93（5），2147-2159

11. Xiangzhao Mao，Shi Chen，Yaling Shen*，Dongzhi Wei*，Zixin Deng，Effect of copper sulfate on biosynthesis of FR-008/Candicidin complex production in Streptomyces sp.，World Journal of Microbiology and Biotechnology，2011，27（9），2033–2039

主要专著：

1． Steven L Nail（美国）等著，童望宇，沈亚领，张勰旻等译，《蛋白质药物-开发与生产》，北京，化学工业出版社，2006

2． 余儒均，李爽，沈亚领：氨基酸，《生物化学品》（王家勤主编），1-45，北京，中国物质出版社，2001

3． Moser. A 著，曲音波，沈亚领等译：《生物工艺技术学——动力学及反应器》（Springer Verlag New York Inc.授权湖南科学技术出版社，1994）