邵旭升

邵旭升

教授，博士生导师。                                                                                                                                    

2009年7月毕业于华东理工大学应用化学专业，导师李忠教授。2012年至2013年在美国加州大学伯克利分校John E. Casida教授课题组进行农药的毒理、代谢和作用机制研究。主要研究方向为绿色农药创制与应用、光药理学、杀虫剂作用的生物学机制。在PNAS、J. Agric. Food Chem.、Insect Biochem. Mol. Biol.等杂志发表SCI论文80多篇，其中第一或通讯作者论文40多篇；申请国内外专利50多项，获中国专利授权6项，国外专利授权21项；是新烟碱杀虫剂哌虫啶和环氧虫啶的主要发明人；国内外重大学术会议邀请报告20多次；获中国专利优秀奖、中国农药工业协会农药创新贡献奖-技术创新奖一等奖和二等奖各一项，入选上海市浦江人才计划和校青年英才计划，获上海市优秀博士论文以及上海市科创杯一等奖2次。作为项目负责人承担国家重点研发计划子课题、国家自然科学基金、上海市科技创新行动计划，澳大利亚DC研究基金等多项科研项目。 

研究方向

1) 绿色农药创制

2) 光药理学

3) 农药毒理学

4) 合成方法学 

1) 国家自然科学基金（面上，项目编号：21877039）：“光致异构杀虫剂的创制及其对靶酶和昆虫的实时调控”，2019.01–2022.12。

2) 国家重点研发计划（2018YFD0200101）：课题一：高效低风险小分子杀虫剂研发与示范（项目：高效低风险小分子农药和制剂研发与示范）；2018.07-2020.12。

3) 上海市“科技创新行动计划”农业领域项目(16391902300)：杀虫剂高效低毒化、智能可控及增效新机制研究。2016.09-2019.09。 

4) 上海市浦江人才计划 (14PJD012):“光控杀虫剂的创制及其应用研究” 2014.09.01-2016.08.31。

5) 国家自然科学基金（面上，项目编号：21372079）：“酰胺键构型调控的双酰胺杀虫剂创制研究”，2014.01–2017.12。

6) 上海市教育委员会科研创新项目（项目编号：12ZZ057）：“针对抗性和蜜蜂毒性的多环新烟碱类杀虫剂创制研究”，2012.1–2014.12。

7) 国家自然科学基金（青年，项目编号：21002030）：“基于π–π堆积作用的偶氮类新烟碱杀虫剂的创制研究”，2011.01–2013.12。

8) 澳大利亚DC研究基金：“Nitromethylene Neonicotinoids with Cis-configuration or Enhanced π-π Stacking Interaction”，2011.1–2013.12。

近期论文

（1）Cuncun Zhou, Liping Ren, Yunfan, Ji, Xusheng Shao*. Photochromic Meta-diamides for Optical Modulation of Ligand Activity and Neuron Function. Photochemical & Photobiological Sciences (Photochem. Photobio. Sci.), 2020, DOI: 10.1039/D0PP00045K.

（2）邵旭升、杜少卿、李忠、钱旭红. 中国绿色农药的研究和发展。世界农药，2020，42(4)，16-30. 

（3）Qi Xu, Yujun Shen, Yongchao Zhang; Xusheng Shao*. PEGylated Cyanine Dye Nanoparticles as Photothermal Agents for Mosquito and Cancer Cell Control. Bioorg. Med. Chem. Lett. 2019, 29, 2398-2404.

（4）Yifei Jing, Qi Xu, Meijun Chen, Xusheng Shao*. Pyridone-containing Phenalenone-based Photosensitizer Working Both under Light and in the Dark for Photodynamic Therapy. Bioorg. Med. Chem. 2019, 27, 2201-2208.

（5）李忠, 邵旭升。中国农药研究与应用全书-农药创新卷，化学工业出版社，北京，出版日期：2019年11月1日；ISBN978-7-122-33892-1；

（6）Zhiping Xu, Shen Li, Yujun Shen, Xusheng Shao*. Spiropyran-azobenzene-DBU System as Solvent Indicator. Tetrahedron Lett. 2018, 59, 3829-3832.

（7）Zhiping Xu, Zhenhong Gao, Xusheng Shao*. Light-triggered release of insecticidally active spirotetramat-enol. Chin. Chem. Lett. 2018. 29, 1648-1650.

（8）Qingqing Hou, Yifei Jing, Xusheng Shao*. Synthesis and insecticidal activities of 1,8-naphthyridine derivatives. Chin. Chem. Lett. 2017, 28, 1723-1726.

（9）Zhenhong Gao, Yifei Jing, Donghui Wang, Zhiping Xu, Zhong Li, Xusheng Shao*. Photo-controlled Release of Fipronil from a Coumarin Triggered Precursor. Bioorg. Med. Chem. Lett. 2017, 27, 2528-2535.

（10）Yanan Zhang, Yian Feng, Zhong Li, Xusheng Shao*. Synthesis and Insecticidal Evaluation of Phytoalexin Phenalenones Derivatives. Chin. Chem. Lett. 2017, 28, 1228-1231.

（11）Xue Tian, Chao Zhang, Qi Xu, Zhong Li and Xusheng Shao*. Azobenzene-Benzoylphenylureas as Photoswitchable Chitin Synthesis Inhibitors. Org. Biomol. Chem. 2017, 15, 3320-3323.

（12）Runjiang Song, Yian Feng, Donghui Wang, Zhiping Xu, Zhong Li, Xusheng Shao*. Phytoalexin Phenalenone Derivatives Inactivate Mosquito Larvae and Root-knot Nematode as Type-Ⅱ Photosensitizer. Sci. Rep. 2017, 7, 42058.

（13）Yian Feng, Minming Zou, Runjiang Song, Xusheng Shao*, Zhong Li, Xuhong Qian. Formation of 1,4,2-Dithiazolidines or 1,3-Thiazetidines from 1,1-Dichloro-2-nitroethene and Phenylthiourea Derivatives. J. Org. Chem. 2016, 81, 10321-10327.

（14）Shen Li, Runjiang Song, Donghui Wang, Xue Tian, Xusheng Shao*, Zhong Li. Azopyridine-imidacloprid derivatives as photoresponsive neonicotinoids. Chin. Chem. Lett. 2016, 27, 635-639.

  (15)  Jiling Li, Dang Wu, Xiaoyong Xu, Jin Huang, Xusheng Shao* and Zhong Li*. Design, synthesis and inhibitory activity against human dihydroorotate dehydrogenase (hDHODH) of 1, 3-benzoazole derivatives bearing amide units. Bioorg. Med. Chem. Lett. 2016, 26, 3064-3066.

  (16) Fengjuan Zhu, Xue Tian, Xusheng Shao*, Zhong Li. Direct Amidation of Aniline Derivatives with 1,1-Dichloro-2-nitroethene in Water. Tetrahedron Lett. 2015, 56, 5945-5949.

  (17) Zhiping Xu, Lina Shi, Danping Jiang, Jiagao Cheng, Xusheng Shao*, Zhong Li. Azobenzene Modified Imidacloprid Derivatives as Photoswitchable Insecticides: Steering Molecular Activity in a Controllable Manner. Sci. Rep. 2015, 5, 13962.

  (18) Fengjuan Zhu, Minming Zou, Xusheng Shao*, Zhong Li. On-water, Catalyst-Free and Room-temperature Construction of 2-Aryl-1,3,4-oxadiazole Derivatives from 1,1-Dichloro-2-nitroethene and Hydrazides. RSC Advance 2015, 5, 61752-61758.

  (19) Nanyang Chen, Xiaoqing Meng, Fengjuan Zhu, Jiagao Cheng, Xusheng Shao*, Zhong Li. Tetrahydroindeno[1’,2’:4,5]pyrrolo[1,2-a]imidazol-5(1H)-ones as Novel Neonicotinoid Insecticides: Reaction Selectivity and Substituent Effects on the Activity Level. J. Agric. Food Chem. 2015, 63, 1365-1369.

 (20) Minming Zou, Nanyang Chen, Liping Ren, Xusheng Shao*, Zhong Li. A novel and facile synthesis of 2-oxo-1,2-dihydropyridine-fused 1,3-diazaheterocycles via heterocyclic ketene aminals and Knoevenagel adducts formed by phthalic anhydride and ethyl cyanacetate. Chin. Chem. Lett. 2014, 25, 1515-1519.

 (21) Nanyang Chen, Minming Zou, Xue Tian, Fengjuan Zhu, Danping Jiang, Xusheng Shao*, Zhong Li* Isomerization of Ninhydrin-Heterocyclic Ketene Aminals Adducts: Kinetic versus Thermodynamic Control, Solvents Dependency and Mechanism. Eur. J. Org. Chem. 2014, 28, 6210-6218.

 (22) Liping Ren, Yanpeng Lou, Nanyang Chen, Shanshan Xia, Xusheng Shao*, Xiaoyong Xu, Zhong Li. Synthesis and Insecticidal Activities of Tetrahydroimidazo[1,2-a]pyridinones: Further Exploration on cis-Neonicotinoids. Synthetic Commun. 2014, 44, 858-867.

 (23) Xusheng Shao*, Shanshan Xia, Kathleen A. Durkin, John E. Casida*. Insect Nicotinic Receptor Interactions in Vivo with Neonicotinoid, Organophosphorus and Methylcarbamate Insecticides and a Synergist. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 17273–17277.

 (24) Xusheng Shao, Tami L. Swenson, John E. Casida*. Cycloxaprid Insecticide: Nicotinic Acetylcholine Receptor Binding Site and Metabolism. J. Agric. Food Chem. 2013, 61, 7883–7888.

 (25) Xusheng Shao, Zewen Liu, Xiaoyong Xu, Zhong Li*, Xuhong Qian. Overall Status of Neonicotinoid Insecticides in China: Production, Application and Innovation. J. Pestic. Sci. 2013, 38, 1–9.

 (26) Xusheng Shao, Zhenjun Ye, Haibo Bao, Zewen Liu, Xiaoyong Xu, Zhong Li*, Xuhong Qian*. Advanced research on cis-neonicotinoids. Chimia 2011, 65, 957–960.

 (27) Xusheng Shao, Hanyan Liu, Haibo Bao, Xiaoyong Xu, Zewen Liu, Zhong Li*. The Mode of Action of a Nitroconjugated Neonicotinoid and the Effects of Target Site Mutation Y151S on its Potency. Insect Biochem. Mol. Biol. 2011, 41, 440–445. (Insect Biochemistry and Molecular Biology),

 (28) Xusheng Shao, Philip W. Lee, Xiaoyong Xu, Zewen Liu, Zhong Li*, Xuhong Qian. cis-Configuration: A New Tactic/Rationale for Neonicotinoid Molecular Design. J. Agric. Food Chem. 2011, 59, 2943–2949.

 (29) Xusheng Shao, Hua Fu, Xiaoyong Xu, Xinglei Xu, Zhong Li*, Zewen Liu. Divalent and Oxabridged Neonicotinoids Constructed by Dialdehydes and Nitromethylene Analogues of Imidacloprid: Design, Synthesis, Crystal Structure and Insecticidal Activities. J. Agric. Food Chem. 2010, 58, 2696–2702.

 (30) Xusheng Shao, Zhiping Xu, Xianfeng Zhao, Xiaoyong Xu, Liming Tao, Zhong Li*, Xuhong Qian*. Synthesis, crystal structure, and insecticidal activities of highly congested hexahydroimidazo[1,2-a]pyridine derivatives: effect of conformation on activities. J. Agric. Food Chem. 2010, 58, 2690–2695.

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