钱江潮

发布时间：2018-09-05 13:09:00

钱江潮 工学博士，教授，博士生导师。

1989. 9～1999. 7在华东理工大学生物工程系/学院先后获得学士、硕士和博士学位，毕业留校后长期从事生物技术领域的研究工作。近年来，主持包括国家自然科学基金面上项目、“973”课题、国家重点研发计划课题等多项省部级科研项目。入选上海市“浦江人才”计划和教育部新世纪优秀人才支持计划。

工作经历

2011. 9 ～至今华东理工大学生物工程学院研究员

2006. 9 ～ 2011. 8 华东理工大学生物工程学院副研究员

2005. 10 ～ 2006. 8 华东理工大学生物工程学院助理研究员

2003. 9 ～ 2005. 9 美国宾夕法尼亚大学（university of Pennsylvania）医学院博士后

1995. 7 ～ 2003. 8 华东理工大学生物工程学院助教/助理研究员

研究方向

1. 代谢工程：优化遗传操作手段，应用代谢调控和系统分析，结合高通量筛选和分析，优化和构建微生物细胞工厂。

2. 生物材料的生物效应：纳米无机材料抗肿瘤及其机理研究。

代表论文

1. Qin XL, Lu JJ, Zhang Y, Wu XL, Qiao XF, Wang ZP, Chu J, Qian JC*. Engineering Pichia pastoris to improve S-adenosyl-l-methionine production using systems metabolic strategies. Biotechnol. Bioeng., 2020, 117 (5): 1436-1445.

2. Duan GD, Ding LM, Wei DS, Zhou HC, Chu J, Zhang SL, Qian JC*. Screening endogenous signal peptides and protein folding factors to promote the secretory expression of heterologous proteins in Pichia pastoris. J. Biotechnol., 2019, 306: 193-202.

3. Sun Y, Devore D, Ma XY, Yuan Y, Kohn J*, Qian JC*. Promotion of dispersion and anticancer efficacy of hydroxyapatite nanoparticles by the adsorption of fetal bovine serum. J. Nanopart. Res., 2019, 21: 267.

4. Sun Y, Chen YY, Ma XY, Yuan Y, Liu CS, Kohn J, Qian JC*. Mitochondria-targeted hydroxyapatite nanoparticles for selective growth inhibition of lung cancer in vitro and in vivo. ACS Appl. Mater. Interfaces, 2016, 8(39): 25680-25690.

5. Cui XH, Liang T, Liu CS, Yuan Y*, Qian JC*. Correlation of particle properties with cytotoxicity and cellular uptake of hydroxyapatite nanoparticles in human gastric cancer cells. Mat. Sci. Eng. C, 2016, 67: 453-460.

6. Wu YQ, Tang W, Wang P, Liu CS, Yuan Y*, Qian JC*. Cytotoxicity and cellular uptake of amorphous silica nanoparticles in human cancer cells. Part. Part. Syst. Charact., 2015, 32(7): 779-787.

7. Tang W, Yuan Y, Liu CS, Wu YQ, Lu X, Qian JC*. Differential cytotoxicity and particle action of hydroxyapatite nanoparticles in human cancer cells. Nanomedicine, 2014, 9(3): 397-412.

8. Yao GF, Qin XL, Chu J, Wu XL, Qian JC*. Expression, purification and characterization of a recombinant methionine adenosyltransferase pDS16 in Pichia pastoris. Appl. Biochem. Biotech., 2014, 172(3): 1241-1253.

9. Chu J*, Qian JC, Zhuang YP, Zhang SL, Li YR. Progress in the research of S-adenosyl-L-methionine production. Appl. Microbiol. Biotechnol., 2013, 97 (1): 41-49.

10. Qin XL, Qian JC*, Xiao CY, Zhuang YP, Zhang SL,Chu J*. GAP promoter library for fine-tuning gene expression in Pichia pastoris. Appl. Environ. Microb., 2011, 77(11): 3600-3608.

11. Qin XL, Qian JC*, Xiao CY, Zhuang YP, Zhang SL,Chu J*. Reliable high-throughput approach for screening of engineered constitutive promoters in the yeast Pichia pastoris. Lett. Appl. Microbiol., 2011, 52(6): 634-641.

12. Wu JQ, Zhang QL, Deng W, Qian JC, Zhang SL, Liu W*. Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination. Appl. Environ. Microb., 2011, 77 (21): 7508-7516.

13. Qian JC, Qin XL, Yin Q,Chu J, Wang YH*. Cloning and characterization of Kluyveromyces marxianus Hog1 gene. Biotechnol. Lett., 2010, 33(3): 571-575.

14. Zhang QL, Wu JQ, Qian JC*,Chu J, Zhuang YP, Zhang SL, Liu W*. Knocking out of tailoring genes eryK and eryG in an industrial erythromycin-producing strain of Saccharopolyspora erythraea leading to overproduction of erythromycin B, C, and D at different conversion ratios. Lett. Appl. Microbiol., 2010, 52: 129-137.

15. Zhao QH, Qian JC*, Zhou HJ, Yuan Y, Mao YH, Liu CS*. In vitro osteoblast-like and endothelial cells' response to calcium silicate/calcium phosphate cement. Biomed. Mater., 2010, 5(3): 035004.

16. Zhang SL*,Cao XJ,Chu J, Qian JC, Zhuang YP. Bioreactors and Bioseparation, Biotechnology in China: Chemicals, Energy & Envronment. Advances in Biochemical Engineering-Biotechnology, 2010, 122: 105-150.

17. Hu H, Qian JC*, Chu J*, Wang Y, Zhuang YP, Zhang SL. DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-L-methionine production in Pichia pastoris. J. Biotechnol., 2009, 141(3-4): 97-103.

18. Hu H, Qian JC*,Chu J*, Wang YH, Zhuang YP, Zhang SL. Optimization of L-Methionine feeding strategies for improving S-adenosyl-Lmethionine production by methionine adenosyltransferase overexpressed Pichia pastoris. Appl. Microbiol. Biotechnol., 2009, 83(6): 1105-1114.

19. Zhou HJ, Qian JC, Wang J, Yao WT, Liu CS*, Chen JG andCao XH.Enhancedbioactivity of bone morphogenetic protein-2 with low dose of 2-N, 6-O-sulfated chitosan in vitro and in vivo. Biomaterials, 2009, 30 (9): 1715-1724.

20. Chen Y, Deng W, Wu JQ, Qian JC,Chu J, Zhuang YP, Zhang SL*, Liu W*. Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation. Appl. Environ. Microb., 2008, 74 (6): 1820-1828.

21. Qian JC, Lavker RM, Tseng H*. Mapping ribosomal RNA transcription activity in the mouse eye. Dev. Dynam., 2006, 235(7): 1984-1993.

22. Qian JC*, Cai XP,Chu J, Zhuang YP, Zhang SL. Nucleotide mutations in purA gene and pur operon promoter discovered in guanosine- and inosine-producing Bacillus subtilis strains. Biotechnol. Lett., 2006, 28(12): 937-941.

出版专著

1. 钱江潮, 袁媛, 汤薇, 陆逊, 刘昌胜. 羟基磷灰石纳米颗粒的抗肿瘤生物效应. 硬组织修复材料与技术 (刘昌胜主编), 北京, 科学出版社, 2014, 407-439.

授权专利

1. 钱江潮, 段广东, 魏东升, 王志朋, 储炬, 庄英萍, 张嗣良, 肖慈英, 陶丽媛. 调节目标蛋白表达的折叠因子及其应用.专利号: ZL 201610983966.0, 授权公告日: 2020.4.17.

2. 钱江潮, 张莹, 王志朋, 陆俊杰, 储炬, 庄英萍, 张嗣良, 肖慈英. 通过调节碳代谢途径基因提高S-腺苷甲硫氨酸产量的方法. 专利号ZL 201610888006.6, 授权公告日: 2020.9.18.

3. 钱江潮, 丁璐妹, 张嗣良. 四种毕赤酵母内源信号肽及其应用. 专利号ZL 201510387762.6, 授权公告日: 2019-3-19.

4. 钱江潮, 陆俊杰, 乔雪锋, 秦秀林, 储炬, 庄英萍, 张嗣良. 一种通过调控gln1基因表达提高S-腺苷甲硫氨酸产量的方法. 专利号: ZL 201410294493.4, 授权公告日: 2016-12-5.

5. 钱江潮, 陆俊杰, 乔雪锋, 秦秀林, 储炬, 庄英萍, 张嗣良. 一种通过调控gln1基因表达提高S-腺苷甲硫氨酸产量的方法. 专利号: ZL 201410294493.4, 授权公告日: 2016-12-5.

6. 刘昌胜, 邢万里, 王靖, 钱江潮, 梁婧. 一种融合蛋白的应用. 专利号ZL 201210553208.7, 授权公告日: 2016-2-3.

7. 钱江潮, 秦秀林, 于晓光, 储炬, 武晓乐, 庄英萍, 张嗣良. GAP启动子文库在调节S-腺苷甲硫氨酸代谢途径中的应用. 专利号 ZL 201010621230.1, 授权公告日: 2013-10-9.

8. 刘昌胜, 林俊, 钱江潮, 袁媛. 优化的基于大肠杆菌表达系统的重组人骨形态发生蛋白-2的DNA序列及重组人骨形态发生蛋白-2的制备. 专利号 ZL 200910045832.4, 授权公告日: 2013-6-19.

9. 钱江潮, 秦秀林, 储炬, 庄英萍, 张嗣良, 肖慈英. GAP启动子文库及其用途. 专利号 ZL 2009 1 0053198.9, 授权公告日:2012-12-26.

10. Changsheng Liu, Jun Lin, Jiangchao Qian, Yuan Yuan, Optimized DNA sequences encoding recombinant human bone morphogenetic protein-2 (rhbmp-2), preparation method and the uses thereof. Patent No US 7947821 B2, Date of Patent May 24, 2011.

11. 庄英萍, 王晖, 储炬, 张嗣良, 钱江潮, 王永红. 重组的降糖肽及其生产菌株的构建和培养方法. 专利号 ZL 200710037133.6, 授权公告日: 2011-1-12.

获奖

1. 2008年上海市科技进步一等奖：先进技术集成的红霉素生产新工艺. (6)

2. 2011年国家科技进步二等奖: 基于细胞生理与过程信息处理的工业发酵优化新技术. (6)

联系方式

电话：021-64250736 传真：021-64253702 E-mail: jiangchaoqian@ecust.edu.cn

通讯地址：上海市梅陇路130号，华东理工大学329信箱，200237