牟伯中

牟伯中，工学博士、教授、博士生导师

应用化学研究所 所长，生物采油教育部工程研究中心 主任

IBB、AEB、微生物学杂志等6本刊物编委

中国化学会胶体与界面化学专业委员会委员

中国微生物学会地质微生物专业委员会委员

享受国务院政府特殊津贴，第十一届、十二届上海市政协委员

主要研究方向及成果:

主要从事生物物理化学和界面物理化学方面的研究工作。以极端环境多孔介质中微生物活动为背景，研究微生物的生物物理化学过程与界面反应机制，包括 (1) 生物表面活性剂及生物基表面活性剂的结构与性能，(2) 石油烃厌氧生物降解产甲烷途径与生物标志物，以及 (3) CO₂生物转化途径与调控机制。目前的重点应用领域是生物表面活性剂和生物采油技术。近年来负责承担国家重点研发计划专项项目、国家863计划重点、国家自然科学基金重点、上海市基础研究重点项目及国际合作研究等多项重点科研任务。在国际学术刊物发表论文 (SCI) 200余篇，申请发明专利50余项 (其中授权专利30余项)，已经实现转让和产业化的专利技术产生了良好的经济与社会效益。作为第一完成人获得国家科技进步二等奖、上海市科技进步一等奖、中国产学研合作创新成果一等奖等科研成果奖。

教学方面，主讲本科生《物理化学》课程和研究生《生物物理化学》等课程。先后承担国家首批双语教学示范课程 “《物理化学》双语教学示范课程“ 和教育部 “工科化学系列课程双语教学体系的研究与建设“ 等教学研究项目。曾获宝钢优秀教师奖、国家教学成果二等奖、上海市教学成果一等奖和华东理工大学教学成果一等奖等教学成果奖。

主持的主要科研项目 (2010~)：

国家重点研发计划专项项目(课题编号：2017YFB0308901，起止时间：2017-2021)

国家自然科学基金重点项目 (项目编号：41530318，起止时间：2016-2020)

上海市国际合作研究项目(项目编号：18230743300，起止时间：2018-2020)

上海市基础研究重点项目 (项目编号：15JC1401400，起止时间：2015-2018)

国家863计划重点项目 (项目编号：2009AA063503，起止时间：2009-2011)

国家自然科学基金面上项目 (项目编号：51174092，起止时间：2012-2015)

国家自然科学基金面上项目 (项目编号：41073055，起止时间：2011-2013)

国家自然科学基金面国际 (地区) 合作项目 (项目编号：41161160560, 起止时间：2012-2014)

Dr. Bo-Zhong Mu is a professor and the head of Institute of Applied Chemistry, East China University of Science and Technology (ECUST), and the director of the Engineering Research Center for Microbial Enhanced Oil Recovery, the Ministry of Education, China.

Dr. Bo-Zhong Mu joined the East China University of Science and Technology as a full professor in the January 2001, where he heads a group in the interdisciplinary area of Microbial Enhance Oil Recovery. These interdisciplinary studies have been supported by the National Natural Science Foundation of China, the National High-Tech Research and Development Program, the International Joint Research programs, and by the industrial partners of PetroChina and SINOPEC. He has actively joined in the collaborative research with domestic and international communities.

He once worked at the laboratory for geodrilling fluid chemistry, China Coal Research Institute (Xian) after his graduation from Chengdu University of Technology in 1982 till 1995, where he was involved in studies of complex colloidal systems in geodrilling engineering, and received his M.S. degree in 1989. He studied Applied Chemistry, in particular, the interfacial chemistry of porous media and fundamentals for enhanced oil recovery at the state key laboratory headed by Academician Pingya Luo in the Southwest Petroleum University. After receiving his Ph.D. in Applied Chemistry in 1998, he moved to the Ocean University of Qingdao for his postdoctoral research, and to the University of Wyoming (Wyoming, USA) for the research in microbial enhanced oil recovery (MEOR).

 
His Research interests focus on the chemical & biological fundamentals for enhanced oil recovery, including interfacial behavior & microbial transport in porous media, bio-based surfactants & their molecular aggregates, and molecular microbial community & biodegradation in petroleum reservoirs. His interests also lie in the extension of the research to application with industrial partners, covering MEOR, the methanegenic production from residue oil, and CO₂ biofixation in situ oil reservoirs. Since joining ECUST in 2001, He has published more than 200+ peer-reviewed articles, and was awarded the First Class Prize of Shanghai Science and Technology Progress Award in 2008 and the Second Class Prize of National Science and Technology Progress Award in 2010.

Teaching duties involve a number of Chemistry and Biotechnology classes at BSc, MSc and PhD levels, including the courses of Physical Chemistry, Biophysical Chemistry, and Energy Biotechnology.

主要论文 (Selected peer-reviewed articles)：

Microbial Surfactants & Bio-based Surfactants:

(1)    Gang H-Z, He H, Yu Z-Q, Wang Z-Y, Liu J-F, He X-J, Bao X-N, Li Y-C*, Mu B-Z*. A coarse-grained model for microbial lipopeptide surfactin and its application in self-assembly. J Phys Chem B, 2020, 124: 1839-1846

(2)    Liu J-F, Feng J-Y, Yang S-Z, Gang H-Z & Mu B-Z*. The recovery of viscosity of HPAM solution in presence of high concentration sulfide ions. J Petrol Sci Eng, 2020, 195,107605

(3)   Liu J-F, Feng J-Y, Hu H, Li C-Y, Yang S-Z, Gu J-D, Mu B-Z*. Decrease in viscosity of partially hydrolyzed polyacrylamide solution caused by the interaction between sulfide ion and amide group, J Petrol Sci Eng, 2018, 170: 738-743

(4)    Gang H-Z, Galvagnion C, Müller T, Buell A K, Levin A, Dobson C M*, Mu B-Z*, Knowles TPJ*. Characterisation of the interactions between α-synuclein and lipid vesicles under native conditions from microfluidic measurements of molecular diffusivity. Anal Chem, 2018, 90:3284-3290

(5)   Gang H-Z, Liu J-F, Mu B-Z*. Binding structure and kinetics of surfactin monolayer formed at the air/water interface to counterions: a molecular dynamics simulation study. BBA Biomembranes, 2015, 1848:1955-1962

(6)   She A-Q, Gang H-Z, Mu B-Z*. Temperature influence on the structure and interfacial properties of surfactin micelle: a molecular dynamics simulation study. J Phys Chem B, 2012, 116: 12735-12743

(7)   Gang H-Z, Liu J-F, Mu B-Z*. Molecular dynamics study of surfactin monolayer at the air/water interface. J Phys Chem B, 2011, 115: 12770-12777  

(8)    Gang H-Z, Liu J-F, Mu B-Z*. Interfacial behavior of surfactin at the decane/water interface: a molecular dynamics simulation. J Phys Chem B, 2010, 114: 14947-14954

(9)   Gang H-Z, Liu J-F, Mu B-Z*. Molecular dynamics simulation of surfactin derivatives at the decane / water interface at low surface coverage. J Phys Chem B, 2010, 114: 2728-2737

(10)  Li Y, Zou A-H, Ye R-Q, Mu B-Z*. Counterion-induced changes to the micellization of surfactin-C16 aqueous solution. J Phys Chem B, 2009, 113: 15272 -15277

Biodegradation of Hydrocarbons in Depleted Oil Reservoirs:

(11)  Liu Y-F, Chen J, Liu Z-L, ShouL-B, Lin D-D, Zhou L, Yang S-Z, Liu J-F, Li W, Gu J-D, Mu B-Z*. Anaerobic degradation of paraffins by a novel class-level lineage of syntrophic Actinobacteria under methanogenic condition. Environ Sci Technol, 2020, 54:10610-10620

(12)  Liu Y-F, Chen J, Zaramela L, Wang L-Y, Mbadinga MS, Hou Z-W, Wu X-L, Gu J-D Zengler K*, Mu B-Z*. Genomic and transcriptomic evidence supports methane metabolism in Archaeoglobi. mSystems, 2020, 5,19

(13)  Liu Y-F, Qi Z-Z, Shou L-B, Liu J-F, Yang S-Z, Gu J-D, Mu B-Z*. Anaerobic hydrocarbon degradation in candidate phylum ‘Atribacteria’ (JS1) inferred from genomics. ISEM J, 2019, 13: 2377–2390

(14)  Ji J-H, Liu Y-F, Zhou L, Mbadinga SM, Pan P, Chen J, Liu J-F, Yang S-Z, Sand W, Gu J-D*, Mu B-Z*. Evidences for the initial activation by fumarate addition mechanism in methanogenic degradation of long n-alkanes, Appl Environ Microbiol 85, 2019, e00985-19

(15)  Chen J, Liu Y-F, Zhou L, Mbadinga SM, Yang T, Zhou J, Liu J-F, Yang S-Z, Gu J-D, Mu B-Z*. Methanogenic degradation of branched alkanes in enrichment cultures of production water from a high-temperature petroleum reservoir. Appl Microbiol Biotech, 2019, 103:2391–2401

(16)  Liu Y-F, Galzerani D D, Mbadinga S M, Zaramela LS, Gu J-D, Mu B-Z*, Zengler K*. Metabolic capability and in situ activity of microorganisms in an oil reservoir. Microbiome, 2018, 6:5

(17)  Pan P, Hong B, Mbadinga SM, Wang L-Y, Liu J-F, Yang S-Z, Gu J-D, Mu BZ*. Iron oxides alter methanogenic pathways of acetate in production water of high-temperature petroleum reservoir. Appl Microbiol Biotech, 2017,101: 7053-7063

(18)  Li C-Y, Zhang D, Li X-X, Mbadinga SM, Yang S-Z, Liu J-F, Gu J-D, Mu B-Z*. The biofilm property and its correlationship with high-molecular-weight polyacrylamide degradation in a water injection pipeline of Daqing oilfield. Journal of Hazardous Materials, 2016, 304: 388–399

(19)  Mbadinga SM, Li K-P, Zhou L, Wang L-Y, Yang S-Z, Liu J-F, Gu J-D, Mu B-Z*. Analysis of alkane-dependent methanogenic community derived from production water of high temperature petroleum reservoir. Appl Microbiol Biotech, 2012, 96:531-42

(20)  Wang L-Y, Li W, Mbadinga SM, Liu J-F, Gu J-D, Mu B-Z*. Microbial community shift correlated with the carbon available enriched from an oily sludge over 500 days of methanogenic incubation. Geomicrobiol J, 2012, 29:716-726

Biotransformation of CO₂ in Petroleum Reservoirs & CCUS:

(21)  Liang T-T, Zhou L, Irfan M, Bai Y, Liu X-Z, Zhang J-L Wu Z-Y Wang W-Z Liu J-F Cheng L, Yang S-Z, Ye R-Q, Gu J-D, Mu B-Z*. Assessment of five electron shuttling molecules in extracellular electron transfer of electromethanogenesis by Methanosarcina barkeri. ChemElectroChem, 2020, 7: 3783-3789

(22)  Bai Y, Zhou L, Irfan M, Liang T-T, Cheng L, Liu Y-F, Liu J-F, Yang S-Z, Sand W, Gu J-D, Mu B-Z*. Bioelectrochemical methane production from CO2 by Methanosarcina barkeri via direct and H2-mediated indirect electron transfer. Energy, 2020, 210,118455

(23)  Yuan S, Gang H-Z, Zhou L, Liang T-T, Irfan M, Kazmi M, Liu J-F, Yang S-Z, Mu B-Z*. Insight into the Adsorption Mechanism of CO2, CH4, and their Mixtures on Kerogen Type IIIA, Energy & Fuels, 2020 (DOI: 10.1021/acs.energyfuels.0c01368)

(24)  Irfan M, Zhou L, Ji J-H, Chen J, Yuan S, Liang T-T, Liu J-F, Yang S-Z, Gu J-D, Mu B-Z*. Enhanced energy generation and altered biochemical pathways in an enrichment microbial consortium amended with natural iron minerals. Renewable Energy, 2020,159:585-594

(25)  Irfan M, Zhou L, Ji J-H, Yuan S, Liu J-F, Yang S-Z, Gu J-D, Mu B-Z*. Energy recovery from the carbon dioxide for green and sustainable environment using iron minerals as electron donor. J Clean Prod, 2020, 277,124134

(26)  Irfan M, Zhou L, Bai Y, Yuan S, Liang T-T, Liu Y-F, Liu J-F, Yang S-Z, Gu J-D & Mu B-Z *. Insights into the H2 generation from water-iron rock reactions at low temperature and the key limiting factors in the process. Int’l J Hydrogen Energy, 2019, 44: 18007-180018

(27)  Irfan M, Bai Y, Zhou L, Kazmi M, Yuan S, Mbadinga SM, Yang S-Z, Jin Liu F, Sand W, Gu J-D & Mu B-Z*. Direct microbial transformation of of CO2 to value-added chemicals: A comprehensive analysis and application potentials, Bioresource Technology, 2019, 288:121401

(28)  Ma L, Zhou, Ruan M-Y, Gu J-D, Mu B-Z*. Simultaneous methanogenesis and acetogenesis from CO2 by enrichment cocultures supplemented with ZVI, Renewable Energy, 2019, 132:861-870

(29)  Ma L, Zhou L, Mbadinga SM, Gu J-D, Mu B-Z*. Accelerated CO2 reduction to methane for energy by zero valent iron in oil reservoir production waters. Energy, 2018, 147:663-671

(30)  Yang G-C, Zhou L, Mbadinga SM, Liu J-F, Yang S-Z, Gu J-D, Mu B-Z*. Formate-dependent microbial conversion of CO2 and the dominant pathways of Methanogenesis in production water of high-temperature oil reservoirs amended with bicarbonate. Front Microbiol, 2016, 7, 365

SRB & Biocorrosion in Oil Fields

(31)  Zhou L, Wang DW, Zhang SL, Tang EG, Lu YW, Jing YF, Lin DD, Liu ZL, Liu JF, Yang SZ, Zhang J*, Gu JD, Mu BZ*. Functional microorganisms involved in the sulfur and nitrogen 2 metabolism in production water from a high-temperature offshore 3 petroleum reservoir. IBB, 2020, 154,105057

(32)  Li X-X, Yang T, Mbadinga SM, Liu J-F, Yang S-Z, Gu J-D, Mu B-Z*. Responses of microbial community composition to temperature gradient and carbon steel corrosion in production water of petroleum reservoir. Front Microbiol, 2017, 8,2379

(33)  Li X-X, Liu J-F, Zhou L, Mbadinga S M, Yang S-Z, Gu J-D, Mu B-Z*. Diversity and composition of sulfate-reducing microbial communities based on genomic DNA and RNA transcription in production water of a high temperature and corrosive oil reservoir. Front Microbiol,2017, 8, 1011

(34)  Li X-X, Mbadinga SM , Liu J-F, Zhou L, Yang S-Z, Gu J-D, Mu B-Z*. Microbiota and their affiliation with physiochemical characteristics of different subsurface petroleum reservoirs. IBB, 2017, 120 170-185

(35)  Li C-Y, Hu H, Feng J-Y, Mbadinga SM, Liu J-F, Yang S-Z, Gu J-D, Mu B-Z*. Diversity and abundance of ammonia-oxidizing bacteria (AOB) revealed by amoA gene in a polyacrylamide transportation system of an oil field. IBB,2016, 115:110-118

(36)  Li X-X, Liu J-F, Yang S-Z, Mbadinga SM, Gu J-D, Mu B-Z*. Dominance of Desulfotignum in sulfate-reducing community in high sulfate production-water of high temperature and corrosive petroleum reservoirs. IBB, 2016, 114: 45-56

(37)  Guan J, Zhang B-L, Mbadinga S M, Liu J-F, Gu J-D, Mu B-Z*. Functional genes (dsr) approach reveals similar sulphidogenic prokaryotes diversity but different structure in saline waters from corroding high temperature petroleum reservoirs. Appl Microbiol Biotech, 2014, 98:1871-1882

(38)  Guan J, Xia L-P, Wang L-Y, Liu J-F, Gu G-D, Mu B-Z*. Diversity and distribution of sulfate- reducing bacterial communities in four different petroleum reservoirs using 16S rRNA gene from nested PCR and dsrAB gene. IBB, 2013, 76:58-66

(39)  Li W, Wang L-Y, Duan R-Y, Liu J-F, Gu G-D, Mu B-Z*. Microbial community composition in n-alkanes -amended enrichment cultures of nitrate-reducing, sulfate-reducing and methanogenic conditions from production water of a mesophilic petroleum reservoir. IBB, 2012, 69: 87-96

(40)  Feng W-W, Liu J-F, Gu G-D, Mu B-Z*. Nitrate-reducing community in production water of three oil reservoirs and their responses to different carbon sources revealed by nitrate-reductase gene (napA). IBB, 2011, 65 :1081- 1086

Microbial Communities in Petroleum Reservoirs & Enhanced Energy Recovery:

(41)  Zhou Z-C, Liang B, Wang L-Y, Liu JF, Mu B-Z*, Shim H, Gu J-D*. Identifying the core bacterial microbiome of hydrocarbon degradation and a shift of dominant methanogenesis pathways in the oil and aqueous phases of petroleum reservoirs of different temperatures from China. Biogeosciences, 2019,16:4229-4241

(42)  Liang B, Zhang K, Wang L-Y, Liu J-F, Yang S-Z, Gu J-D, Mu B-Z*. Insight into archaeal communities in the aqueous and oil phases of production fluid from a high-temperature petroleum reservoir. Front Microbiol, 2018, 9, 841

(43)  Liu Y-F, Mbadinga SM, Gu J-D, Mu B-Z*. Type II chaperonine gene as a complementary barcode for 16S rRNA gene in study of Archaea diversity of petroleum reservoirs. IBB, 2017, 123: 113-120

(44)  You J, Wu G, Ren F-P, Qi C, Yu B*, Xue Y-F, Mu B-Z*. Microbial community dynamics in Baolige oilfield during MEOR treatment revealed by Illumina MiSeq sequencing,  Appl Microbiol Biotech, 2016, 100: 1469 -1478

(45)  Liu J-F, Sun X-B, Mbadinga SM, Yang G-C, Gu J-D, Mu B-Z*. Microbial communities in water samples from oil fields previously subjected to CO2-flooding and thoroughly water-flooding using functional genes as molecular markers with respect to microbial fixation of sequestered CO2. Front Microbiol, 2015, 6: 236.

(46)  Wang L-Y, Sun X-B, Liu J-F, Gu J-D, Mu B-Z*. Comparison of bacterial community in aqueous and oil phases of the water-flooded petroleum reservoir using Pyrosequencing and clone library approaches. Appl Microbiol Biotech, 2014, 98:4209-4221

(47)  Guan J, Zhang B-L, Mbadinga SM, Liu J-F, Gu J-D, Mu B-Z*. Functional genes (dsr) approach reveals similar sulphidogenic prokaryotes diversity but different structure in saline waters from corroding high temperature petroleum reservoirs. Appl Microbiol Biotech, 2014, 98 :1871-1882

(48)  Wang L-Y, Duan R-Y, Liu J-F, Yang S-Z, Gu J-D, Mu B-Z*. Molecular analysis of the microbial community structures in water-flooding petroleum reservoirs with different temperatures. Biogeosciences, 2012, 9: 4645-4659

(49)  Li H, Yang S-Z, Mu B-Z*, et al. Molecular phylogenetic diversity of the microbial community associated with a high-temperature petroleum reservoir at an offshore oilfield. FEMS microbiol ecol, 2007, 60: 74-84

(50)  Li H, Yang S-Z, Mu B-Z*, et al. Molecular analysis of bacterial community structure in a continental high-temperature and water-flooded petroleum reservoir. FEMS Microbiol Lett, 2006, 257: 92-98

Presentations：

(1)    Mu B-Z, Mbadinga S M, Gu J-D. Microbial communities in subsurface petroleum reservoirs and their potentials in microbial enhanced energy recovery. 10th International Congress on Chemical Engineering and Biotechnology, 9-12 May, 2016, Beijing (Invited)

(2)    Mu B-Z, Mbadinga S M, Gu J-D. Role of microbial community in subsurface petroleum reservoirs. Sino German Workshop on Microbial Enhanced Oil Recovery, 20-24 April, 2015 Leipzig, Germany (Invited)

(3)    Mu B-Z, Zhang Q-Q, Gu J-D, Sand W. Bio-based surfactant for enhanced oil recovery and oil spill treatment, ACHEMA 2015 Congress, 15-19 June, 2015, Frankfurt, Germany (Invited)

(4)    Mu B-Z, Zhang Q-Q. Biobased Surfactants. ECF2015 5th Asia Shale Gas Summit,12-14 Oct. 2015, Shanghai (Invited)

(5)    Mu B-Z, Mbadinga S M, Wang Y-L, Zhou L, Gu J-D, Suflita,J. Role of microbial community in subsurface petroleum reservoirs: the potential application in microbial enhanced energy recovery. China-US Joint Annual Symposium, Water, Energy, and Ecosystem Sustainable Development, 26-28 Oct, 2014, Hefei (keynote)

(6)    Mu B-Z, Bian X-Y, Mbadinga S M, Gu J-D. Detection of signature biomarkers implicated in anaerobic degradation of hydrocarbons in petroleum reservoirs via Mass spectral characteristics of chemically synthesized alkylsuccinates. International Symposium on Applied Microbiology and Molecular Biology in Oil Systems (ISMOS-4), 25-28 Aug, 2013, Rio, Brazil (Invited)

(7)    Mu B-Z, Bian X-Y, Mbadinga S M, Gu J-D. Identification of alkylsuccinate synthase genes and characterization of microbial community structure in distinct petroleum reservoirs fluids of China, International Symposium on Applied Microbiology and Molecular Biology in Oil Systems (ISMOS-3), 13-15 June, 2011, Calgary (Invited)

(8)    Mu B-Z, Wang Y-L, Mbadinga SM, Zhou L, Liu J-F, Gu J-D. Molecular microbial community in water-flooding petroleum reservoirs with different temperatures. The First International Conference on Geomicrobial Ecotoxicology, 28-31 May, 2011, Wuhan (Keynote)

(9)    Mu B-Z, Wang Y-L, Mbadinga S M, Zhou L, Liu J-F, Gu J-D. Phylogenetic diversity of the Archaeal community in petroleum reservoirs with different temperatures. Inaugural Meeting of BERGEY’s International Society for Microbial Systematics, 19-23 May, 2011, Beijing (Invited)

(10)  Mu B-Z, Wang Y-L, Liu J-F, Yang S-Z. Molecular characterization of the Archaeal community in water-flooding petroleum reservoirs. Asian Congress on Biotechnology (ACB-2011), 11-15 May, 2011, Shanghai (Invited)

通讯地址：上海市梅陇路130号 (200237)，华东理工大学326信箱

实验室地址：实验三楼225室

联系电话: 021-64252063 

Email: bzmu@ecust.edu.cn