刘建文

1994年毕业于上海中医药大学中医肿瘤治疗学专业，获得医学博士学位；1995年应日本国科学技术厅邀请，作为STA Fellow在大阪生物科学研究所（Osaka Bioscience Institute）和日本理化学研究所（Institute of Physical and Chemical Research）进行客座研究。研究天然药物对血管内皮细胞纤溶活性因子的基因调空作用。2001年毕业于日本广岛大学(省立)遗传子制御工学研究室，研究自由基与癌转移的过程及实验药物干预的分子机理，获得应用生物科学博士学位。现主要研究领域涉及的领域：分子细胞药理学，毒理学，肿瘤学，细胞生物学，分子生物学，中药学。现主要研究方向：细胞周期阻滞及凋亡诱导剂的发现与作用机理研究；肿瘤细胞凋亡小RNA表达、调控的研究及其在新药研发中的应用；基于肿瘤光动力的分子模型的建立及先导化合物的发现研究；纳米材料与技术在生命科学中的应用基础研究。先后主持和参与国家和省部级科研课题。先后参与获省部级科研成果1等奖2项，2等奖4项、3等奖2项，申请发明专利11项，国际发明专利1项，发表国内外论文近150篇，其中SCI收录120篇。主编《药理实验方法学—新技术与新方法》，《生物资源中活性物质的开发与利用》等4部著作。 

近年发表论文

1, Qianyi Gong, Changfeng Song, Xiaotong Wang, Renjie Wang, Guoxiang Cai, Xin Liang, Jianwen Liu:  Hyperthermic intraperitoneal chemotherapy with recombinant mutant human TNF-α and raltitrexed in mice with colorectal-peritoneal carcinomatosis. Experimental Biology and Medicine 2020,245,(6):542-551

2, Xiaoying Ma, Jiajun Liu, Xiaotong Yang, Kai Fang, Peiyong Zheng*, Xin Liang*, Jianwen Liu*: Mesenchymal stem cells maintain the stemness of colon cancer stem cells via interleukin-8/mitogen-activated protein kinase signaling pathway[J]. Experimental Biology and Medicine. 2020, 245: 562-575.

3, Ximeng Shi, Yuyu Zhao, Licheng Zhou, Huanhuan Yin, Jianwen Liu,* and Lei Ma: Design, Synthesis and Biological Evaluation of Dimethyl Cardamonin (DMC) Derivatives as P-glycoprotein-mediated Multidrug Resistance Reversal Agents. Letters in Drug Design & Discovery, 2020, 17, 000-000

4，Xiaotong Yang, Xiaoying Ma, Ocholi Don, Yuanlin Song, Xiaoyan Chen, Jianwen Liu* , Jieming Qu* , Yun Feng*. Mesenchymal stem cells combined with Liraglutide relieve acute lung injury through apoptotic signaling restrained by PKA/β-catenin. Stem Cell Research &Therapy. 2020,11:182

5, Xiaoying Ma, Jiajun Liu, Jiyu Li, Yueqi Li, Van Minh Le, Shaoyu Li, Xin Liang, Lingshuang Liu,  Jianwen Liu*: miR‐139‐5p reverses stemness maintenance and metastasis of colon cancer stem‐like cells by targeting E2‐2 J Cell Physiol. 2019;1–16.  4.522

6, Huanhuan Yin, Jingjing Dong, Yingchun Cai, Ximeng Shi, Hao Wang, Guixia Liu,

Yun Tang, Jianwen Liu, Lei Ma: Design, synthesis and biological evaluation of chalcones as reversers. European Journal of Medicinal Chemistry 180 (2019) 350e366 

7,  Chang Su, DongPing Huang, Jianwen Liu, Weiyan Liu and Yiou Cao: miR‑27a‑3p regulates proliferation and apoptosis of colon cancer cells by potentially targeting BTG1 ONCOLOGY LETTERS  18: 2825-2834, 2019 1.871

8, Wenshuang Yuan, Chang Su, Xiaotong Yang, Yueqi Li, Yiou Cao, Xin Liang, Jianwen Liu: Biological and anti‐vascular activity evaluation of ethoxy‐erianin phosphate as a vascular disrupting agent of P-glycoprotein-mediated multidrug resistance. J Cell Biochem. 2019;1-12.

9, Xiangyu Gu, Yayuan Peng, Bubing Zeng, Yuyu Zhao, Yun Tang , Xin Liang*, Jianwen Liu*: A novel derivative of Artemisinin inhibits cell proliferation and metastasis via down-regulation of Cathepsin K in breast cancer. European Journal of Pharmacolog 858 (2019) 172382-93 3.17

10,Wenshuang Yuan, Chang Su, Xiaotong Yang, Yiou Cao, Jianwen Liu*: Biological and anti-vascular activities evaluation of  Ethoxy-Erianin phosphate as vascular disrupting agents J Cell Biochem. 2019; 120:16978-16989. 

11. Yuyu Zhao, Jiajun Xu, Van Minh Le, Qianyi Gong, Shaoyu Li, Feng Gao, Lei Ni*, Jianwen Liu*, Xin Liang*: EpCAM Aptamer-Functionalized Cationic Liposome-Based Nanoparticles Loaded with miR-139-5p for Targeted Therapy in Colorectal Cancer. Mol. Pharmaceutics 2019, 16, 4696-4710  

12,  Xin Liang*, Weixia Chen, Haiyang Shi, Xiangyu Gu, Yueqi Li, Yingxue Qi, Ke Xu*, Aiguang Zhao*, Jianwen Liu*. PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing. Cell Death & Disease. 2018, 11:117   

13, Yueqi Li, Yiyang Chen, Cen Qiu, Xiaoying Ma, Kecheng Lei, Guoxiang Cai, Xin Liang, Jianwen Liu*: 17-allylamino-17-demethoxygeldanamycinimpeded chemotherapy through antioxidant activation via reducing ROS-induced cell death. J Cell Biochem. 2018;1-17.

14. Yingxue Qi, Wenchun Chen, Xinyu Liang, Ke Xu*, Xiangyu Gu, Fengying Wu, Xuemei Fan, Shengxiang Ren, Junling Liu, Jun Zhang6, Renhao Li, Jianwen Liu*, Xin Liang*: Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction Journal of Hematology & Oncology. 2018, 11(1):117. 

15. Weiwei Chen, Xiaoying Ma, Peng Zhang, Qifeng Li, Xin Liang, Jianwen Liu*:MiR-212-3p inhibits LPS-induced inflammatory response through targeting HMGB1 in murine macrophages. Experimental Cell Research   2017, 318–326.

16, Van Minh Le, Trung Duc Tran Nho, Hai Trieu Ly, Thanh Sang Vo, Hoang Dung Nguyen, Thi Thu Huong Phung, Aihua Zou and Jianwen Liu*: Enhanced anticancer efficacy and tumor targeting through folate-PEG modified nanoliposome loaded with 5-fluorouracil. Adv. Nat. Sci.: Nanosci. Nanotechnol. 8 (2017) 015008 (7pp)

17. Xin Liang, Haiyang Shi, Liyan Yang, Cen Qiu, Shengchao Lin, Yingxue Qi, Jiyu Li, Aiguang Zhao, and Jianwen Liu*: Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells.  Br J Cancer. 2017 Mar 28;116(7):903-911 

18. Lei K, Liang X, Gao Y , Xu B, Xu Y , Li Y , Tao Y , Shi W, Liu J*. Lnc-ATB Contributes to Gastric Cancer Growth Through a MiR-141-3p/TGFβ2 Feed back Loop. Biochemical and Biophysical Research Communications 2017 Mar 11; 484(3): 514-521.

19, Xin Liang⁠, Jingjing Wang⁠, Weiwei Chen⁠, Xiaoying Ma⁠, Yaqin Wang⁠, Norio Nagao⁠, Weiyu Weng⁠⁠,, JianmingHuang⁠⁠, Jianwen Liu* Inhibition of airway remode ling and inflammation by isoforskolin in PDGF-induced rat ASMCs and OVA-induced rat asthma model Biomedicine & Pharmacotherapy 2017; 95:275-286

20. Cen Qiu, Yueqi Li, Xin Liang, Yingxue Qi, Liyan yang, Yiyang Chen, Xianke Meng, Hongtu Zheng, Ye Xu, Sanjun Cai, Guoxiang Cai, and Jianwen Liu*: A study of peritoneal metastatic xenograft model of colorectal cancer in the treatment of hyperthermic intraperitoneal chemotherapy with raltitrexed. Biomedicine & Pharmacotherapy 2017,  92:149-156.

22. Shengchao Lin, Kecheng Lei, Wenpei Du, Liyan Yang, Haiyang Shi, Yuwei Gao, Peihao Yin, Xin Liang, Jianwen Liu*: Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. The International Journal of Biochemistry & Cell Biology 2016,71: 24-34

23. Yuanhong Zheng, Guifang Yin, Vanminh Le, Anle Zhang, Peihao Yin, Jianwen Liu*, Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, Which Generates Vaccine for Cancer Therapy Int J Biol Sci  2016; 12(1): 120-132

24. Liyan Yang, Qiannan Liang, Ke Shen, Li Ma, Na An, Weiping Deng, Zhewei Fei, Jianwen Liu:A novel class I histone deacetylase inhibitor, I-7ab, induce apoptosis and arrest cell cycle progression in human colorectal cancer cells. Biomedicine & Pharmacotherapy  2015,71: 70-78      

25. Van-Minh Le, Jing-Jing Wang, Ming Yuan, The-Long Nguyen, Gui-Fang Ying, Yuan-Hong Zheng, Wei-Bin Shi, Mei-Dong Lang, Lei-Ming Xu, Jian-Wen Liu: An investigation of antitumor efficiency of novel sustained and targeted 5-fluorouracil Nanoparticles. European Journal of Medicinal Chemistry  2015, 92: 882-889

26. Yuanhong Zheng, Fangyuan Zou, Jingjing Wang, Guifang Yin, Vanminh Le, Zhewei Fei, and Jianwen Liu*: Photodynamic Therapy-mediated Cancer Vaccination Enhances Stem-like Phenotype and Immune Escape, Which Can Be Blocked by Thrombospondin-1 Signaling through CD47 Receptor Protein. J Biol Chem. 2015, 290: 8975-8986.

27. Kecheng Lei & Shaoying Tan & Wenpei Du & Yichun Xu & Shengchao Lin & Yuanhong Zheng & Fangyuan Zou &Yufang Xu & Jianwen Liu:3B, a novel of photosensitizer, exhibited anti-tumor effects via mitochondrial apoptosis pathway in MCF-7 human breast carcinoma cells. Tumor Biol. 2015, 36:5597–5606 

7. Rurong Mao, Fangyuan Zou, Liyan Yang, Shengchao Lin, Yueqi Li, Mingxing Ma, Peihao Yin, Xin Liang, Jianwen Liu*: The Loss of MiR-139-5p Promotes Colitis-Associated Tumorigenesis by Mediating PI3K/AKT/Wnt Signaling International Journal of Biochemistry and Cell Biology 2015,69:153–161

联系方式

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