李洪林

发布时间：2018-09-04 18:09:00

李洪林

药学专业：博士生导师/硕士生导师

计算机科学与工程专业：博士生导师/硕士生导师

2000年6月，毕业于大连理工大学化工学院，获学士学位；2005年6月，毕业于大连理工大学工程力学系，获博士学位；2005年7月-2008年5月，在中国科学院上海药物所博士后；2008年5月华东理工大学药学院任教授；2009年3月-2009年6月，美国明尼苏达大学短期访问；2012年3月，受聘华东理工大学特聘教授。他先后获得上海市“青年科技启明星计划”（2010）、教育部“新世纪优秀人才支持计划”（2010）、“天鼎－东岳”研究生奖教金特等奖（2011）、国家自然科学基金委优秀青年科学基金（2012）、上海市“青年科技启明星计划”跟踪（2013）、第十六届“明治生命科学奖”（2013）、第十三届中国青年科技奖（2013）、“曙光计划”（2013）、霍英东教育基金会第十四届高等院校青年教师基金（2013）、“”青年拔尖人才（2014）等人才计划资助和奖励。现为上海市新药设计重点实验室主任、生物反应器工程国家重点实验室成员、华东理工大学药学学科专业委员会主任。他已在PNAS、Cancer Res.、Nucl. Acids Res.、J. Med. Chem.和J. Chem. Inf. Model.等期刊上发表论文100余篇，参与5部专著的编写，申请发明专利56项（已授权16项），PCT专利5项，获软件版权6项。

主要研究方向：

1. 药物设计、计算生物学和化学信息学的新方法发展；

2. 针对肿瘤、炎症及疟疾等疾病靶标开展实际的药物发现；

3. 结合计算及实验方法开展先导化合物优化及临床前研究；

4. 药物靶标预测方法及网络/多向药理学方法和平台的建立；

5. 计算及生物学手段开展天然产物的靶标识别及实验验证；

6. 通过计算生物学和结构生物学等手段开展药物-靶标作用机理研究。

学术梯队：

1. 赵振江，博士，副教授。承担国家自然科学基金项目，主要从事激酶抑制剂的优化合成研究。

2. 朱丽丽，博士，副教授。承担国家自然科学基金和上海市自然科学基金项目，主要从事结构生物学研究。

3. 刘晓峰，博士，副研究员。承担国家自然科学基金项目，参加国家科技支撑计划和国家科技重大专项项目，主要从事药物信息和药物设计学研究。

4. 陈卓，博士，讲师。承担国家自然科学基金和上海市自然科学基金项目，主要从事化学生物学研究。

5. 张寿德，博士，师资博士后。承担国家自然科学基金项目，主要从事天然药物化学研究。

代表性研究论文：

1. Shiliang Li, Guoqin Luan, Xiaoli Ren, Wenlin Song, Liuxin Xu, Minghao Xu, Junsheng Zhu, Dong Dong, Yanyan Diao, Xiaofeng Liu, Lili Zhu, Rui Wang, Zhenjiang Zhao*, Yufang Xu*, Honglin Li*. Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity. Sci. Rep., 2015, 5, 14836

2. Junsheng Zhu, Le Han, Yanyan Diao, Xiaoli Ren, Minghao Xu, Liu-Xin Xu, Shiliang li, Qiang Li, Dong Dong, Jin Huang, Xiaofeng Liu, Zhenjiang zhao, Rui Wang, Lili Zhu*, Yufang Xu, Xuhong Qian*, and Honglin Li*. Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole-Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase. J. Med. Chem., 2015, 58(3), 1123-1139

3. Fang Bai, Sha Liao, Junfeng Gu, Hualiang Jiang, Xicheng Wang, and Honglin Li*. An Accurate Metalloprotein-Specific Scoring _function and Molecular Docking Program Devised by a Dynamic Sampling and Iteration Optimization Strategy. J. Chem. Inf. Model., 2015, 55, 833-847

4. Xia Wang, Haipeng Chen, Feng Yang, Jiayu Gong, Shiliang Li, Jianfeng Pei*, Xiaofeng Liu*, Hualiang Jiang, Luhua Lai and Honglin Li*. iDrug, a web-accessible and interactive drug discovery and design platform. J. Cheminform., 2014, 6, 28

5. Fang Bai, YechunXu, Jing Chen, Qiufeng Liu, JunfengGu, Xicheng Wang, Jianpeng Ma, Honglin Li*, José N. Onuchic*, and Hualiang Jiang*. Free energy landscape for binding process of Huperzine A to acetylcholinesterase. PNAS. 2013, 110(11) : 4273-4278.

6. Wei Zhou, Xiaofeng Liu, ZhengchaoTu, Lianwen Zhang, Xin Ku, Fang Bai, Zhenjiang Zhao, YufangXu*, Ke Ding*, and Honglin Li*. Discovery of pteridin-7(8H)-one-based Irreversible Inhibitors targeting Epidermal Growth Factor Receptor (EGFR) Kinase T790M/L858R mutant. J. Med. Chem., 2013, 56, 7821?7837.

7. MinghaoXu, Junsheng Zhu, YanyanDiao, Hongchang Zhou, XiaoliRen, Deheng Sun, Jin Huang, Dongmei Han, Zhenjiang Zhao, Lili Zhu*, YufangXu*, Honglin Li*. Novel Selective and Potent Inhibitors of Malaria Parasite DihydroorotateDehydrogenase: Discovery and Optimization of Dihydrothiophenone Derivatives. J. Med. Chem., 2013, 56, 7911?7924.

8. Jiayu Gong, Chaoqian Cai, Xiaofeng Liu*, Xin Ku, Hualiang Jiang, Daqi Gao and Honglin Li*. ChemMapper: a versatile web server for exploring pharmacology and chemical structure association based on molecular 3D similarity method. Bioinformatics, 2013, 29(14), 1827-1829

9. Chaoqian Cai, Jiayu Gong, Xiaofeng Liu, Daqi Gao*, Honglin Li*. SimG: An Alignment Based Method for Evaluating the Similarity of Small Molecules and Binding Sites. J. Chem. Inf. Model., 2013, 53, 2103–2115

10. YanyanDiao, Weiqiang Lu, Huangtao Jin, Junsheng Zhu, Le Han, MinghaoXu, RuiGao, XuShen, Zhenjiang Zhao, Xiaofeng Liu, YufangXu, Jin Huang, and Honglin Li*. Discovery of Diverse Human Dihydroorotate Dehydrogenase Inhibitors as Immunosuppressive Agents by Structure-Based Virtual Screening. J. Med. Chem., 2012, 55, 8341?8349.

11. Xiaofeng Liu, Hualiang Jiang, Honglin Li*. SHAFTS: A Hybrid Approach for 3D Molecular Similarity Calculation. 1. Method and Assessment of Virtual Screening. J. Chem. Inf. Model., 2011, 51 (9), 2372–2385.

12. Weiqiang Lu, Xiaofeng Liu, Xianwen Cao, MengzhuXue, Kangdong Liu*, Zhenjiang Zhao, XuShen, Hualiang Jiang, YufangXu, Jin Huang*, andHonglin Li*. SHAFTS: A Hybrid Approach for 3D Molecular Similarity Calculation. 2. Prospective Case Study in the Discovery of Diverse p90 Ribosomal S6 Protein Kinase 2 Inhibitors to Suppress Cell Migration. J. Med. Chem., 2011, 54, 3564–3574.

13. Jing Deng, EnguangFeng, Sheng Ma, Yan Zhang, Xiaofeng Liu, Honglin Li*, Huang Huang, Jin Zhu, Weiliang Zhu, XuShen, Liyan Miao*, Hong Liu, Hualiang Jiang, and Jian Li*. Design and Synthesis of Small Molecule RhoA Inhibitors: A New Promising Therapy for Cardiovascular Diseases? J. Med. Chem., 2011, 54(13), 4508-4522.

14. Li Liu, Xiaofeng Liu, Jiayu Gong, Hualiang Jiang, and Honglin Li*. Accelerating All-Atom Normal Mode Analysis with Graphics Processing Unit. J. Chem. Theory Comput., 2011, 7 (6), 1595-1603.

15. Xiaofeng Liu, SishengOuyang, Biao Yu, Yabo Liu, Kai Huang, Jiayu Gong, SiyuanZheng, Zhihua Li, Honglin Li*, Hualiang Jiang. PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach. Nucl. Acids Res. 2010, 38, W609–W614.

16. Xiaofeng Liu, HuaXie*, Cheng Luo, Linjiang Tong, Yi Wang, Ting Peng, Jian Ding, Hualiang Jiang and Honglin Li*. Discovery and SAR of Thiazolidine-2,4-dione Analogues as Insulin-like Growth Factor-1 Receptor (IGF-1R) Inhibitors via Hierarchical Virtual Screening. J. Med. Chem. 2010, 53 (6), 2661–2665.

联系方式：

地址：上海市徐汇区梅陇路130号实验十八楼527室

电话/传真：021-64250213

邮箱：hlli@ecust.edu.cn

网页：http://lilab.ecust.edu.cn