花强

发布时间：2018-09-04 18:09:00

花强

生物工程学院教授

生物反应器工程国家重点实验室教授

博士生导师

学习及工作经历
2008–至今华东理工大学生物生物工程学院、反应器工程国家重点实验室教授
2007–2008 美国Burnham医学研究所生物信息学和系统生物学部门研究科学家
2004–2007 美国加州大学圣迭戈分校生物工程系博士后学者
2001–2004 日本庆应大学先端生命科学研究所助理教授
1996–2000 日本九州工业大学生命科学和生物信息学系，工学博士
1989–1996 浙江大学化工系生物化学工程专业，工学学士、工学硕士
研究内容及方向
研究重点在于开发基于代谢物质量同位素标记异构体信息的代谢网络解析法、基因组规模代谢网络模型的构建及模拟仿真等系统代谢工程技术，并将这些新型技术应用于理解和改造若干菌株的代谢功能，使之更有效地合成抗肿瘤次级代谢物或萜类化合物等，具体包括：
1. 微生物细胞的代谢工程及系统生物技术开发
2. 细胞基因组规模代谢网络模型的开发及应用研究
3. 放线菌细胞代谢解析及抗生素合成的代谢工程改造
4. 酵母菌作为细胞工厂合成脂肪酸类、萜类等有用化合物
近期论文
Gu DQ, et al. Reframed genome-scale metabolic model to facilitate genetic design and integration with expression data. IEEE/ACM Transactions on Computational Biology and Bioinformatics, DOI: 10.1109/TCBB.2016.2576456.
Wei SS, et al. Reconstruction of genome-scale metabolic model of Yarrowia lipolytica and its application in overproduction of triacylglycerol. Bioresources and Bioprocessing, 4:51, 2017.
Cao X, et al. Enhancing linalool production by engineering oleaginous yeast Yarrowia lipolytica. Bioresource Technology, 245(B):1641-1644, 2017.
Jian XX, et al. Model-guided identification of novel gene amplification targets for improving succinate production in Escherichia coli NZN111. Integrative Biology, 9:830-835, 2017.
Zhao C, et al. Metabolomic changes and metabolic responses to expression of heterologous biosynthetic genes for lycopene production in Yarrowia lipolytica. Journal of Biotechnology, 251(3):174-185, 2017.
Zhao MJ, et al. Effects of methylmalonyl-CoA metabolic pathway on ansamitocin production in Actinosynnema pretiosum. Applied Biochemistry and Biotechnology, 181(3):1167-1178, 2017.
Jian XX, et al. In silico profiling for cell growth and succinate production in Escherichia coli NZN111. Bioresources and Bioprocessing, 3:48, 2016.
Cao X, et al. Metabolic engineering of oleaginous yeast Yarrowia lipolytica for limonene overproduction. Biotechnology for Biofuels, 9:214, 2016.
Yang X, et al. Heterologous production of α-farnesene in metabolically engineered strains of Yarrowia lipolytica. Bioresource Technology, 216:1040-1048, 2016.
Jian XX, et al. In silico identification of gene amplification targets based on analysis of production and growth coupling. Biosystems, 145:1-8, 2016.
Fan YX, et al. Effects of modulation of pentose-phosphate pathway on biosynthesis of ansamitocins in Actinosynnema pretiosum. Journal of Biotechnology, 230:3-10, 2016.
Zhang C, et al. Investigating the combinatory effects of biological networks on gene co-expression. Frontiers in Physiology, 7:160, 2016.
Gu DQ, et al. IdealKnock: A framework for efficiently identifying knockout strategies leading to targeted overproduction. Computational Biology and Chemistry, 61:229-237, 2016.
Fan YX, et al. Enhancement of UDPG synthetic pathway improves ansamitocin production in Actinosynnema pretiosum. Applied Microbiology and Biotechnology, 100:2651-2662, 2016.
Zhang C, et al. Applications of genome-scale metabolic models in biotechnology and systems medicine. Frontiers in Physiology, 6:413, 2016.
Nambou K, et al. Flux balance analysis inspired bioprocess upgrading for lycopene production by a metabolically engineered strain of Yarrowia lipolytica. Metabolites, 5(4):794-813, 2015.
Zhang C, et al. Logical transformation of genome-scale metabolic models for gene level applications and analysis. Bioinformatics, 31(14):2324-2331, 2015.
Zhao C. et al. Metabolome analysis and pathway abundance profiling of Yarrowia lipolytica cultivated on different carbon sources. Journal of Biotechnology, 206:42-51, 2015.
Li TL, et al. Improvement of ansamitocin P-3 production by Actinosynnema mirum with fructose as the sole carbon source. Applied Biochemistry and Biotechnology, 175(6):2845-2856, 2015.
Zhang C, et al. Logical transformation of genome-scale metabolic models for gene level applications and analysis. Bioinformatics, 31(14):2324-2331, 2015.
Zhao C, et al. Metabolome analysis and pathway abundance profiling of Yarrowia lipolytica cultivated on different carbon sources. Journal of Biotechnology, 206:42-51, 2015.
Fan YX, et al. Process optimization with alternative carbon sources and modulation of secondary metabolism for enhanced ansamitocin P-3 production in Actinosynnema pretiosum. Journal of Biotechnology, 192:1-10, 2014.
Nambou K, et al. Designing of a “cheap to run” fermentation platform for an enhanced production of single cell oil from Yarrowia lipolytica DSM3286 as a potential feedstock for biodiesel. Bioresource Technology, 173: 324-333, 2014.
Wei LJ, et al. Revealing in vivo glucose utilization of Gluconobacter oxydans 621H Δmgdh strain by mutagenesis. Microbiological Research, 169:469-475, 2014.
Gao Y, et al. Enhancement of ansamitocin P-3 production in Actinosynnema pretiosum by a synergistic effect of glycerol and glucose. Journal of Industrial Microbiology & Biotechnology, 41(1):143-152, 2014.
Zhao C, et al. Evaluation of metabolome sample preparation methods regarding leakage reduction for the oleaginous yeast Yarrowia lipolytica. Biochemical Engineering Journal, 82(15):63-70, 2014.
联系方式
地址：上海市梅陇路130号华东理工大学生物反应器工程国家重点实验室
邮编：200237
电话：021-64250972
Email：qhua@ecust.edu.cn