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实验室概况
储炬
发布时间：2018-09-04 18:09:00
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储炬，工学博士，华东理工大学生物工程学院教授，博士生导师。 |
1963年8月出生于上海，1985获华东化工学院学士学位, 88年获硕士学位。96年于华东理工大学获生物化工工学博士学位。88年毕业后留校从事国家七.五攻关项目，溶氧电极和谷氨酸电极的研制以及葡萄糖氧化酶发酵、提纯工作等。90年10月在大阪大学发酵工学科从事基因工程研究一年；91年应邀到英国Bath大学进行膜发酵研究一年。92年12月回国后,获国家教委资助的留学回国人员基金, 从事螺旋霉素膜过滤发酵研究, 国家自然科学基金项目葡萄糖氧化酶膜透析发酵以及葡萄糖氧化酶菌种选育工作, "利用高技术改进庆大霉素菌种及发酵工艺", "果糖基转移酶"的研究,担任研究生学位课程"发酵调控学"本科生"发酵生理学""生物工程专业英语"等教学工作。97年开始从事九五攻关项目"红霉素发酵新技术研究"及国家86.3子课题，酿酒酵母基因工程菌高密度培养。98年从事毕赤酵母基因工程菌高密度生产表达人血清白蛋白中试研究。99年主持国家自然科学基金项目"小单孢菌分泌机制研究"， 98年任硕士生导师。现为发酵工程硕士点学术带头人之一。1999年晋升为教授，2001年3月晋升为生物化工专业博士生导师, 目前已有20余人获博士学位，其中一人获上海市优秀博士论文。2004年为微生物学硕士点负责人。完成国家“十五”攻关梅岭霉素工艺优化，国家十五“863”及国家十五“863”重大科技专项课题基因工程微生物表达系统发酵过程优化平台技术研究。并与企业合作进行肌苷、鸟苷发酵，阿氟菌素及头孢菌素C及毕赤酵母疟疾疫苗、植酸酶高表达等课题研究。2000年获教育部高等学校骨干教师资助计划，并于2002年获得高等学校优秀骨干教师称号。2001年获上海市曙光计划资助，2006年获曙光跟踪项目资助。2004年分别获得日本明治乳业生命科学奖和韩国SK基金资助。2006年作为项目负责人完成国家十一五“863”重点项目“头孢菌素C发酵工业用菌种改造和代谢工程技术研究（680万元）”及十一五“973”子课题等项目，并且所在研究团队于2011年2月荣获科技部授予的“十一五”国家科技计划执行优秀团队奖。近期正在承担十二五国家重大新药创制项目及教育部高校博士点基金及十二五“973”子课题等项目。作为项目负责人先后和英国GMX公司、韩国CJ公司、荷兰DSM公司及英国Strathclyde大学成功进行国际合作研究。2007年6月至12月在美国佐治亚大学遗传系高级访问学者。表学术论文200余篇。其中SCI收录论文136篇，EI收入100篇。学术专著及教材4部。迄今已申报包括国际PCT在内的发明专利1 项，申报国家发明专利45项，其中17项已经获得授权。2002、2004、2011年3次获得国家科技进步二等奖（分别为第2，第3，第2完成人）。
学术兼职：
上海市药学会抗生素专业委员会副主任委员
华东理工大学学报编委
中国抗生素杂志编委
中国医药工业杂志编委
微生物代谢调控机制及代谢工程研究
工业发酵过程优化与放大
获奖
2011年度国家科技进步二等奖 “基于细胞生理与过程信息处理的工业发酵优化新技术”(第2完成人)
2004年度国家科技进步二等奖 “新型食品添加剂呈味核苷酸二钠关键生产工艺技术”（第3完成人）
2002年度国家科学技术进步二等奖 “基于参数相关的发酵过程生物反应器优化与放大技术”（第2完成人）
2008年度上海市科技进步 一等奖 “先进技术集成的红霉素生产新工艺”（第2完成人）
2003年度上海市科技进步一等奖 “新型食品添加剂鸟苷生产优化与发酵过程多尺度研究 ”（第2完成人）
2001年度上海市科技进步一等奖 “基于过程参数相关的发酵过程优化与放大技术及其生物反应器装置研究”（第2完成人）
2001年获上海市教委“曙光学者”
2002年12月获教育部高等学校优秀骨干教师
2003年3月获上海市三八红旗手
2003年-2004年度上海市科学技术委员会技术预见专家
2004年9月获上海市育才奖
2004年度获“明治乳业生命科学奖”
2006年获上海市教委“曙光跟踪计划”
2006-2007年韩国Dong-A大学
2010年10月获华东理工大学第二届“我心目中的良师益友”奖
2011年博士生周进获上海市优秀博士论文
专著
1、储炬，李友荣. 现代工业发酵调控学 北京：化学工业出版社， 2002年1月；2006年（第二版）；《现代工业发酵调控学2002年9月获第六届石油和化学工业优秀教材奖二等奖。2006年作为教育部学位管理与研究生教育司推荐研究生教学用书。
2、张嗣良，储炬，《微生物发酵过程多尺度研究与优化》，化学工业出版社，2003.9
3、储炬，李友荣《现代生物工艺学》（上下册），华东理工大学出版社，2008.3
4、储炬 李友荣译 《生物化学系统的计算分析[美]Eberhard O.Voit著》,化学工业出版社，2006.1
其中为国外生化工程与生物技术进展系列丛书编写两章
1、Siliang Zhang, Ju Chu, Yingping Zhuang“A Multi-scale Study on Industrial Fermentation Processes and Their Optimization” Advances in Biochemical Engineering and Biotechnlogy, 2004, 87:97-150, Springer-Verlag.
2、Zhang SL. Cao XJ. Chu J. Qian JC. Zhuang YP. Bioreactors and Bioseparation, Biotechnology in China: Chemicals, Energy & Environment. Advances in Biochemical Engineering-Biotechnology. 2010, 122: 105-150
近期发表文章
1. Guo Qian, Chu Ju*, Zhuang Yingping, Gao Yang. Controlling the feed rate of propanol to optimize erythromycin fermentation by on-line capacitance and oxygen uptake rate measurement [J]. Bioprocess and Biosystems Engineering, 2016, 39(2): 255-265.
2. Tian Xiwei, Wang Yonghong*, Chu Ju*, Zhuang Yingping, Zhang Siliang. Enhanced l-lactic acid production in Lactobacillus paracasei by exogenous proline addition based on comparative metabolite profiling analysis [J]. Applied Microbiology and Biotechnology, 2016, 100(5): 2301-2310.
3. Lu Fei, Wang Zejian, Zhao Wei, Chu Ju*, Zhuang Yingping. A simple novel approach for real-time monitoring of sodium gluconate production by on-line physiological parameters in batch fermentation by Aspergillus niger [J]. Bioresource Technology, 2016, 202: 133-141.
4. Tian Xiwei, Zhang Ning, Yang Yi, Wang Yonghong*, Chu Ju*, Zhuang Yingping, Zhang Siliang. The effect of redox environment on l-lactic acid production by Lactobacillus paracasei—A proof by genetically encoded in vivo NADH biosensor [J]. Process Biochemistry, 2015, 50(12): 2029-2034.
5. Lu Hongzhong, Liu Xiaoyun, Huang Mingzhi*, Xia Jianye, Chu Ju*, Zhuang Yingping, Zhang Siliang, Noorman Henk. Integrated isotope-assisted metabolomics and 13C metabolic flux analysis reveals metabolic flux redistribution for high glucoamylase production by Aspergillus niger [J]. Microbial Cell Factories, 2015, 14(1): 147-160.
6. Lu Fei, Ping Kangkang, Wen Lin, Zhao Wei, Wang Zejian*, Chu Ju*, Zhuang Yingping. Enhancing gluconic acid production by controlling the morphology of Aspergillus niger in submerged fermentation [J]. Process Biochemistry, 2015, 50(9): 1342-1348.
7. Tang Wenjun, Pan Ao, Lu Hongzhong, Xia Jianye*, Zhuang Yingping, Zhang Siliang, Chu Ju*, Noorman Henk. Improvement of glucoamylase production using axial impellers with low power consumption and homogeneous mass transfer [J]. Biochemical Engineering Journal, 2015, 99: 167-176.
8. Lu Hongzhong, Li Chao, Tang Wenjun, Wang Zejian, Xia Jianye*, Zhang Siliang, Zhuang Yingping, Chu Ju*, Noorman Henk. Dependence of fungal characteristics on seed morphology and shear stress in bioreactors [J]. Bioprocess and Biosystems Engineering, 2015, 38(5): 917-928.
9. Shi Fei, Tan Jun, Chu Ju*, Wang Yonghong, Zhuang Yingping, Zhang Siliang. A qualitative and quantitative high-throughput assay for screening of gluconate high-yield strains by Aspergillus niger [J]. Journal of Microbiological Methods, 2015, 109: 134-139.
10. Chen Yong, Wang Zejian, Chu Ju*, Xi Beili, Zhuang Yingping. The glucose RQ-feedback control leading to improved erythromycin production by a recombinant strain Saccharopolyspora erythraea ZL1004 and its scale-up to 372-m3 fermenter [J]. Bioprocess and Biosystems Engineering, 2015, 38(1): 105-112.
11. Wang Guan, Tang Wenjun, Xia Jianye, Chu Ju*, Noorman Henk, van Gulik Walter M.. Integration of microbial kinetics and fluid dynamics toward model-driven scale-up of industrial bioprocesses [J]. Engineering in Life Sciences, 2015, 15(1): 20-29.
12. Tan Jun, Chu Ju*, Wang Yonghong, Zhuang Yingping, Zhang Siliang. High-throughput system for screening of Monascus purpureus high-yield strain in pigment production [J]. Bioresources and Bioprocessing, 2014, 1(1): 1-7.
13. Zhang Qiang, Chen Yong, Hong Ming, Gao Yang, Chu Ju*, Zhuang Yingping, Zhang Siliang. The dynamic regulation of nitrogen and phosphorus in the early phase of fermentation improves the erythromycin production by recombinant Saccharopolyspora erythraea strain [J]. Bioresources and Bioprocessing, 2014, 1(1): 1-6.
14. Tian Xiwei, Wang Yonghong*, Chu Ju*, Zhuang Yingping, Zhang Siliang. Oxygen transfer efficiency and environmental osmolarity response to neutralizing agents on l-lactic acid production efficiency by Lactobacillus paracasei [J]. Process Biochemistry, 2014, 49(12): 2049-2054.
15. Tian Xiwei, Wang Yonghong*, Chu Ju*, Zhuang Yingping, Zhang Siliang. l-Lactic acid production benefits from reduction of environmental osmotic stress through neutralizing agent combination [J]. Bioprocess and Biosystems Engineering, 2014, 37(9): 1917-1923.
16. Wang Guan, Chu Ju*, Noorman Henk, Xia Jianye, Tang Wenjun, Zhuang Yingping, Zhang Siliang. Prelude to rational scale-up of penicillin production: a scale-down study [J]. Applied Microbiology and Biotechnology, 2014, 98(6): 2359-2369.
17. Zhu Pei, Chen Daijie, Liu Wenbin, Zhang Jianbin, Shao Lei, Li Ji-an, Chu Ju*. Hydroxylation and hydrolysis: two main metabolic ways of spiramycin I in anaerobic digestion [J]. Bioresource Technology, 2014, 153: 95-100.
18. Chen Yong, Huang Mingzhi, Wang Zejian, Chu Ju*, Zhuang Yingping, Zhang Siliang. Controlling the feed rate of glucose and propanol for the enhancement of erythromycin production and exploration of propanol metabolism fate by quantitative metabolic flux analysis [J]. Bioprocess and Biosystems Engineering, 2013, 36(10): 1445-1453.
19. Tan Jun, Chu Ju*, Hao Yuyou, Wang Yonghong, Yao Sichao, Zhuang Yingping, Zhang Siliang. A high-throughput screening strategy for accurate quantification of erythromycin [J]. Journal of the Taiwan Institute of Chemical Engineers, 2013, 44(4): 538-544.
20. Chen Yong, Wang Zejian, Chu Ju*, Zhuang Yingping, Zhang Siliang, Yu Xiaoguang. Significant decrease of broth viscosity and glucose consumption in erythromycin fermentation by dynamic regulation of ammonium sulfate and phosphate [J]. Bioresource Technology, 2013, 134: 173-179.
21. Tan Jun, Chu Ju*, Hao Yuyou, Guo Yuanxin, Zhuang Yingping, Zhang Siliang. High-throughput system for screening of Cephalosporin C high-yield strain by 48-deep-well microtiter plates [J]. Applied Biochemistry and Biotechnology, 2013, 169(5): 1683-1695.
22. Chu Ju*, Qian Jiangchao, Zhuang Yingping, Zhang Siliang, Li Yourong. Progress in the research of S-adenosyl-L-methionine production [J]. Applied Microbiology and Biotechnology, 2013, 97(1): 41-49.
23. Pethick Florence E., MacFadyen Alison C., Tang Zhenyu, Sangal Vartul, Liu Tze-Tze, Chu Ju, Kosec Grefor, Petkovic Hrvoje, Guo Meijn, Kirby Ralph, Hoskisson Paul A., Herron Paul R., Hunter Iain S*.. Draft genome sequence of the oxytetracycline-producing bacterium Streptomyces rimosus ATCC 10970 [J]. Genome Announc, 2013, 1(2): e00063-13.
24. Tan Jun, Chu Ju*, Shi Wenjuan, Lin Cheng, Guo Yuanxin, Zhuang Yingping, Zhang Siliang, Imanaka Tadayuki. High-throughput screening strategy used for enhanced production of pigment by Monascus purpureus D39-4 [J]. Food Science and Biotechnology, 2012, 21(6): 1603-1610.
25. Yang Yiming, Xia Jianye*, Li Jianhua, Chu Ju*, Li Liang, Wang Yonghong, Zhuang Yingping, Zhang Siliang. A novel impeller configuration to improve fungal physiology performance and energy conservation for cephalosporin C production [J]. Journal of Biotechnology, 2012, 161(3): 250-256.
26. Zou Xiang, Xia Jianye, Chu Ju*, Zhuang Yingping, Zhang Siliang. Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50 L to 132 m3 fermenter [J]. Bioprocess and Biosystems Engineering, 2012, 35(5): 789-800.
27. Wu Dan, Chu Ju*, Hao Yuyou, Wang Yonghong, Zhuang Yingping, Zhang Siliang. Incomplete protein disulphide bond conformation and decreased protein expression result from high cell growth during heterologous protein expression in Pichia pastoris [J]. Journal of Biotechnology, 2012, 157(1): 107-112.
28. Liang Jianguang, Chu Xiaohe, Xiong Zhiqiang, Chu Ju*, Wang Yonghong*, Zhuang Yingping, Zhang Siliang. Oxygen uptake rate regulation during cell growth phase for improving avermectin B1a batch fermentation on a pilot scale (2 m3) [J]. World Journal of Microbiology and Biotechnology, 2011, 27(11): 2639-2644.
29. Wu Dan, Chu Ju*, Hao Yuyou, Wang Yonghong, Zhuang Yingping, Zhang Siliang. High efficient production of recombinant human consensus interferon mutant in high cell density culture of Pichia pastoris using two phases methanol control [J]. Process Biochemistry, 2011, 46(8): 1663-1669.
30. Qin Xiulin， Qian Jiangchao*， Yao Gaofeng， Zhuang Yingping， Zhang Siliang，Chu Ju*， GAP Promoter Library for Fine-Tuning of Gene Expression in Pichia pastoris，A PPLIED AND ENVIRONMENTAL MICROBIOLOGY ，2011，77 （11）: 3600-3608
31.Qin X.，Qian J*.，Xiao C.， Zhuang Y.，Zhang S.， Chu J.*， Reliable high-throughput approach for screening of engineered constitutive promoters in the yeast Pichia pastoris LETTERS IN APPLIED MICROBIOLOGY，2011， 52（6 ）: 634-641
32. Zou Xiang，Li Wan-jun，Zeng Wei，Chu Ju*，Zhuang Ying-ping，Zhang Si-liang， An assessment of seed quality on erythromycin production by recombinant Saccharopolyspora erythraea strain ，BIORESOURCE TECHNOLOGY，2011，102 （3）: 3360-3365
33.Li Jianhua，Yang Yiming，Chu Ju*，Huang, Mingzhi*，Li Liang，Zhang Xiaochun，Wang Yonghong，Zhuang Yingping，Zhang Siliang， Quantitative metabolic flux analysis revealed uneconomical utilization of ATP and NADPH in Acremonium chrysogenum fed with soybean oil， BIOPROCESS AND BIOSYSTEMS ENGINEERING ，2010 ，33 （ 9） : 1119-1129
34.Zou Xiang，Zeng Wei，Chen Chang-fa，Qi Xia-chang，Qian Jiang-chao，Chu Ju*，Zhuang, Ying-ping，Zhang Si-liang，Li Wan-jun，Fermentation Optimization and Industrialization of Recombinant Saccharopolyspora erythraea Strains for Improved Erythromycin A Production ，BIOTECHNOLOGY AND BIOPROCESS ENGINEERING ，2010 ， 15 （6 ）: 959-968
35.Liang Jian-Guang, Chu Xiao-He, Chu Ju* , Wang Yong-Hong, Zhuang Ying-Ping, Zhang, Si-Liang Oxygen uptake rate (OUR) control strategy for improving avermectin B-1a production during fed-batch fermentation on industrial scale (150 m(3)) ,AFRICAN JOURNAL OF BIOTECHNOLOGY ,2010 ,9(42) :7186-7191
36.Zou X, Chen C. –F, Huang H.-F, Chu J*, Zhuang Y-P, Zhang S-L, Response Surface Methodology for Optimization of the Erythromycin Production by Fed-Batch Fermentation Using an Inexpensive Biological Nitrogen Source, CHEMICAL AND BIOCHEMICAL ENGINEERING QUARTERLY, 2010,24(1): 95-2010
37.Xiang Zou , Hai-feng Hang , Ju Chu*, Ying-ping Zhuang, Si-liang Zhang, Oxygen uptake rate optimization with nitrogen regulation for erythromycin production and scale-up from 50 L to 372 m3 scale. Bioresource Technology. 2009, 100 :1406–1412
38.Xiang Zou, Hai-feng Hang , Ju Chu*, Ying-ping Zhuang, Si-liang Zhang , Enhancement of erythromycin A production with feeding available nitrogen sources in erythromycin biosynthesis phase，Bioresource Technology,2009,100 (13) :3358-3365
39.Wang Y, Chu J, Zhuang YP, Wang YH, Xia JY, Zhang SL*, Industrial bioprocess control and optimization in the context of systems biotechnology, Biotechnology Advances,2009, 27(6): 989-995
40. Jin Zhou , Yong-Hong Wang*, Ju Chu*, Ling-Zhi Luo, Ying-Ping Zhuang, Si-Liang Zhang,Optimization of cellulase mixture for efficient hydrolysis of steam-exploded corn stover by statistically designed experiments. BioresourceTechnology ,2009,100 :819–825
41. 18. Zhen-Lin Li, Yong-Hong Wang* , Ju Chu* , Ying-Ping Zhuang and Si-Liang Zhang，Leucine improves the component of isovalerylspiramycins for the production of bitespiramycin，Bioprocess & Biosystem Engineering, 2009, 32: 641-647
42. Hui Hu, Jiangchao Qian*, Ju Chu*, Yonghong, Yingping Zhuang , Siliang Zhang,
Optimization of l-methionine feeding strategy for improving S-adenosyl-l-methionine production by methionine adenosyltransferase overexpressed Pichia pastoris，Applied Microbiology & Biotechnology, 2009, 83 (6): 1105-1114
43. Hui Hu, Jiangchao Qian*, Ju Chu*, Yonghong, Yingping Zhuang , Siliang Zhang,DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-l-methionine production in Pichia pastoris, Journal of Biotechnology, 2009, 141: 97–103
44.Xiang Zou, Hai-feng Hang, Chang-fa Chen, Ju Chu*, Ying-ping Zhuang, Si-liang Zhang，Application of oxygen uptake rate and response surface methodology for erythromycin production by Saccharopolyspora erythraea. J Ind Microbiol Biotechnol 2008, 35:1637–1642
45.Yun Chen, Wei Deng, Jiequn Wu, Jiangchao Qian, Ju Chu, Yingping Zhuang, Siliang Zhang and Wen Liu*. Genetic Modulation of the Overexpression of Tailoring Genes eryK and eryG Leading to the Improvement of Erythromycin A Purity and Production in Fermentation of Saccharopolyspora erythraea. Applied and Environmental Microbiology. 2008, 74(6): 1820-1828.
46. Zhou J, Wang YH*, Chu J*, Zhuang YP, Zhang SL and Yin P. Identification and purification of the main components of cellulases from a mutant strain of Trichoderma viride T 100-14. Bioresource Technology, 2008, 99: 6826–6833.
授权专利
1. 一种提高肌苷发酵过程糖苷转化率及产率的方法，发明申请号：200310122798.9，申请日期：2003-12-25,授权号： ZL 2003 1 0122798.9, 授权日期：2006-01-04, 申请人：储炬，陈双喜，张嗣良，庄英萍
2. 新的蚯蚓纤溶酶及其编码序列与用途，发明专利申请号：200510023241.9，申请日期：2005-01-12, 授权号ZL 2005 1 0023241.9，授权日期：2007-12-19，申请人：储炬，黄文华，秦奕辉，庄英萍，张嗣良
3. 一种发酵生产S-腺苷甲硫氨酸的方法，发明专利申请号：200710036807.0，申请日期：2007-01-25，授权号ZL 2007 1 0036807.0，授权日期：2010-06-16，申请人：储 炬，张 卓，张嗣良，庄英萍，王永红，胡晓清，袁中一
4. 一种S-腺苷甲硫氨酸生产菌株的构建及大规模发酵，发明专利申请号：200610117828.0，申请日期：2006-11-01，授权号ZL 2006 1 0117828.0，授权日期：2009-09-09，申请人：储 炬，胡 辉，王 勇，张嗣良，庄英萍
5. 利用铵离子调控林可霉素发酵过程及提高林可霉素产量，发明专利申请号：200810032954.5，申请日期：2008-01-23，授权号：ZL 2008 1 0032954.5，授权日期：2011-12-21，申请人：储 炬，李 啸，张嗣良，庄英萍，杭海峰，王永红，郭美锦，夏建业
6. 一种重组复合α干扰素的制备方法，专利申请号：200510028285.0 申请日期：2005-07-29, 授权号ZL 2005 1 0028285.0，授权日期：2008-3-5,申请人：储炬，郝玉有，张嗣良，庄英萍，史琪琪，王永红，杭海峰，刘志敏
7. 一种红霉素的制备方法，申请号 200810042768.X，申请日期：2008年9月11日，公开号：CN101671381A，专利授权号：ZL200810042768.X，授权日期：2012-10-10，申请人：储炬，邹祥，李万钧，段洪武，庄英萍，张嗣良
联系方式
华东理工大学 329信箱
生物工程学院实验18楼413室
Email: juchu@ecust.edu.cn
Tel: 021-64253021 Fax:021-64253702