鲍杰

工学博士，教授、博士生导师，生物炼制与能源生物技术团队学术带头人。研究方向为生物炼制与生物能源，研究领域聚焦于木质纤维素生物炼制和生物能源方向的应用基础研究和工业应用。 实验室网页: http://sklbe.ecust.edu.cn/biomasslab

学历

1997-2001 工学博士，日本国立山口大学生物反应工学专业
1995-1997 工学硕士，浙江大学化学反应工程专业
1980-1984 工学学士，南京理工大学化学工程专业

工作经历

2006-现在 华东理工大学生物工程学院教授、博士生导师
2002-2006 美国加州大学戴维斯分校化学工程系博士后研究员
2001-2002 日本国立冈山大学工学部客座研究员
1984-1995 中石化齐鲁石化研究院工程师、课题组长

学术兼职

1. 副主编 (Associate Editor), Applied Biochemistry and Biotechnology (Springer)，2012年至今；
2. 编委 (Editorial Board Member), Biofuels, Bioproducts and Biorefining (Wiley)，2008年至今；
3. 编委 (Editorial Board Member), Bioprocess and Biosystems Engineering (Springer)，2012年至今。
4. 编委, 华东理工大学学报（自然科学版），2009年至今。
5. 客座编辑(Guest Editor), Advances in Biochemical Engineering/Biotechnology (Springer), Bioreactor Engineering Research and Industrial Applications Series, 2014-2015；
6. 客座编辑(Guest Editor), Applied Biochemistry and Biotechnology (Springer)，Environmentally Benign Bioprocesses for Energy and Chemicals Production Special Issue，2008-2009；
7. 客座编辑(Guest Editor), Process Biochemistry (Elsevier)，Bioenergy Production Special Issue，2007-2008。

主讲课程

1. 本科生专业课：生物炼制工程 (Biorefinery Engineering)（双语）
2. 本科生专业课：过程工程过程设计
3. 研究生全英文专业课（硕士）：生物能源过程工程（Bioenergy Process Engineering）
4. 研究生专业课（博士）：生物化工进展

研究团队

2016年度研究团队包括教授1人，副教授1人，讲师1人，博士生13人（包括国际学生2人），硕士生人8人。

研究方向

1. 生物炼制过程技术：以玉米秸秆、麦秆、稻草、蔗渣等木质纤维素生物质为原料，生产液体生物燃料、生物基化学品和可降解生物材料，同时实现农业废弃物减排放、缓解大气污染与二氧化碳的固定。提出了以干式稀酸预处理技术、抑制物生物脱毒技术、高固体含量糖化与发酵技术为代表的干法生物炼制技术和过程技术，实现了生物炼制过程的零废水、低能耗、低成本，达到了迄今最高的纤维素乙醇和化学品发酵技术指标。作为技术提供方为中石油等数家能源和生物科技公司的多项生物能源与资源转化工业示范项目提供了工艺设计软件包、工业装置运行和开车指导。

2. 生物炼制产品技术：以木质纤维素原料生产燃料乙醇、生物柴油等液体生物燃料，以及具有重大产业化潜力的有机酸、氨基酸、多元醇、低聚寡糖产品；建立了以实验和计算力学、Aspen plus流程模拟为核心的生物炼制过程放大技术和工艺软件包，形成应用于产业化应用的成套工业过程技术。

3. 生物炼制代谢工程：抑制物脱毒和戊糖代谢是生物炼制发酵区别于常规粮食淀粉发酵的最本质的关键问题。发现了一系列具有高效生物脱毒功能的特异微生物，建立了高抑制物水平木质纤维素原料的快速生物脱毒技术；对生物炼制发酵微生物的抗逆机制解析从全基因组测序、抑制物胁迫转录组测序和降解代谢路径分析进行了深入研究，精确解明了微生物抗逆机制；对生物炼制发酵微生物进行了代谢工程改造，构建了一系列具备戊糖代谢功能的超级抗逆工程菌。

科研课题

      自2006年实验室成立至今，作为课题负责人主持国家级、省部级等研究课题30多项。代表性课题包括木质纤维素降解转化过程强化的工程学原理与方法（973）、极限低水稀酸预处理技术体系研究（863）、农作物秸秆制备生物化工醇产业化示范（863）、复杂酶反应体系的抑制效应解析与关键路径的加速（国家自然科学基金）、节能与清洁型木质纤维素生产燃料乙醇过程的关键技术研究（中石油）等。

学术著作

1. 《Advances in Biochemical Engineering/Biotechnology Volume 152, 2016. Bioreactor Engineering Research and Industrial Applications II》. Editors: Jie Bao, Qin Ye, Jian-Jiang Zhong. ISBN: 978-3-662-48346-6 (Print)  978-3-662-48347-3 (Online).Springer Berlin Heidelberg, 2016.

2. 《生物炼制产品与技术》，鲍杰，高秋强，张建，曹学君，邓红波译。上海科学技术出版社，2013.ISBN 978-7-5478-1568-7

3. 《现代生物能源技术－美国国家可再生能源实验室生物能源技术报告》（应用生物技术大系丛书），鲍杰译，科学出版社，2009. ISBN 978-7-03-024519-9

近期代表性国际期刊论文

1. Yanqing He, Jian Zhang, Jie Bao*. Acceleration of biodetoxification on dilute acid pretreated lignocellulose feedstock by aeration and the consequent ethanol fermentation evaluation. Biotechnology for Biofuels, 2016, 9:19.

2. Hongsen Zhang, Jian Zhang, Jie Bao*. High titer gluconic acid fermentation by Aspergillus niger from dry dilute acid pretreated corn stover without detoxification. Bioresource Technology, 2016, 203:211-219.

3. Jian Zhang1, Shuai Shao1, Jie Bao*. Long term storage of dilute acid pretreated corn stover feedstock and ethanol fermentability evaluation. Bioresource Technology, 2016, 201:355-359.

4. Xia Yi1, Peng Zhang1, Jiaoe Sun, Yi Tu, QiuqiangGao, Jian Zhang, Jie Bao*. Engineering wild-type robust Pediococcus acidilactici strain for high titer L- and D-lactic acid production from corn stover feedstock. Journal of Biotechnology,2016, 217:112-121.

5. Weiliang Hou1, Ruixin An1, Jian Zhang, Jie Bao*. On-site measurement and modeling of rheological property of corn stover hydrolysate at high solids content. Biochemical Engineering Journal, 2016, 107: 61-65.

6. WeiliangHou, Jian Zhang, Jie Bao*. Rheology evolution and CFD modeling of lignocellulose biomass during extremely high solids content pretreatment. Biochemical Engineering Journal, 2016, 105:412-419.

7. Gang Liu, Jian Zhang, Jie Bao*. Cost evaluation of cellulase enzyme for industrial scale cellulosic ethanol production based on rigorous Aspen plus modeling. Bioprocess and Biosystems Engineering, 2016, 39:133-140.

8. Jian Zhang, WeiliangHou, Jie Bao*. Reactors for high solid loading pretreatment of pretreatment of lignocellulosic biomass. Advances in Biochemical Engineering/Biotechnology,2016, 152:75-90.

9. Hanqi Gu, Jian Zhang, Jie Bao*. High tolerance and physiological mechanism of Zymomonas mobilis to phenolic inhibitors in ethanol fermentation of corncob residue. Biotechnology and Bioengineering, 2015, 112:1770-1782.

10. Xia Yi, HanqiGu, QiuqiangGao, Z. Lewis Liu*,Jie Bao*.Transcriptome analysis ofZymomonas mobilis ZM4 reveals mechanisms oftolerance anddetoxification ofphenolic aldehyde inhibitors fromlignocellulose pretreatment. Biotechnology for Biofuels, 2015, 8:153.

11. Xia Wang, QiuqiangGao, Jie Bao*. Transcriptional analysis of Amorphotheca resinae ZN1 on biological degradation of furfural and 5-hydroxymethylfurfural derived from lignocellulose pretreatment. Biotechnology for Biofuels, 2015, 8:136.

12. Gang Liu1, Jiaoe Sun1, Jian Zhang1,Yi Tu,Jie Bao*. High titerL-lactic acid production from corn stoverwith minimum wastewater generationand techno-economic evaluation based on Aspen plus modeling. Bioresource Technology, 2015, 198:803-810.

13. Ke Liu, Jian Zhang, Jie Bao*. Two stage hydrolysis of corn stover at high solids content for mixing power saving and scale-up applications. Bioresource Technology, 2015, 196:716-720.

14. Abdul Sattar Qureshi, Jian Zhang, Jie Bao*. High ethanol fermentation performance of the dry dilute acid pretreated corn stover by an evolutionarily adapted Saccharomyces cerevisiae strain. Bioresource Technology, 2015, 189:399-404.

15. Jia-Qing Zhu, Lei Qin, Wen-Chao Li, Jian Zhang, Jie Bao, Yao-Dong Huang, Bing-Zhi Li,Ying-Jin Yuan. Simultaneous saccharification and co-fermentation of dry diluted acidpretreated corn stover at high dry matter loading: Overcoming theinhibitors by non-tolerant yeast. Bioresource Technology, 2015, 198:39-46.

16. Juan Wang, Huizhan Zhang*,Jie Bao*. Characterization of inulin hydrolyzing enzyme(s) in oleaginous yeastTrichosporon cutaneumin consolidated bioprocessing of microbial lipid fermentation. Applied Biochemistry and Biotechnology, 2015, 177:1083-1098.

17. Qureshi Abdul Sattar, Jian Zhang*, Jie Bao*. Cellulosic ethanol fermentation using Saccharomyces cerevisiae seeds cultured by pretreated corn stover material. Applied Biochemistry and Biotechnology, 2015,175:3173-3183.

18. Hanjie Li, Chenlin Ye, Ke Liu, Hanqi Gu, Weitao Du, Jie Bao*. Analysis of particle size reduction on overall surface area and enzymatic hydrolysis yield of corn stover. Bioprocess and Biosystems Engineering 2015, 38:149-154.

19. Zichen Luo, Jie Bao*. Secretive expression of heterologousβ-glucosidase in Zymomonas mobilis. Bioresources and Bioprocessing, 2015, 2:29.

20. Long-Ping Zhang, Jian Zhang, Chuan-Hang Li, Jie Bao*. Rheological characterization and CFD modeling of corn stover-water mixing system at high solids loading for dilute acid pretreatment. Biochemical Engineering Journal 2014, 90:324-332.

21. Yanqing He, Zhenhong Fang, Jian Zhang, Xinliang Li, Jie Bao*. De-ashing treatment of corn stover improves the efficiencies ofenzymatic hydrolysis and consequent ethanol fermentation. Bioresource Technology 2014, 169:552-558.

22. Cheng Lei, Jian Zhang, Lin Xiao, Jie Bao*. An alternative feedstock of corn meal for industrial fuel ethanolproduction: Delignified corncob residue. Bioresource Technology2014, 167:555-559.

23. Zhen-Hong Fang, Jian Zhang, Qi-Ming Lu, Jie Bao*. Process development of short-chain polyols synthesis from corn stover by combination of enzymatic hydrolysis and catalytic hydrogenolysis. Biotechnology Reports2014, 3:15-20.

24. ZichenLuo, QiuqiangGao, Xinliang Li, Jie Bao*. Cloning of LicB from Clostridium thermocellum and its efficient secretive expression of thermostable β-1,3-1,4-glucanase. Applied Biochemistry and Biotechnology, 2014, 173:562-570.

25. Yanqing He, Jian Zhang,Jie Bao*. Dry dilute acid pretreatment by co-currently feeding of corn stover feedstock and dilute acid solution without impregnation.Bioresource Technology 2014, 158:360-364.

26. Hong Ran, Jian Zhang, QiuqiangGao, Zhanglin Lin, Jie Bao*. Analysis of biodegradation performance of furfural and 5-hydroxymethylfurfural by Amorphotheca resinae ZN1. Biotechnology for Biofuels 2014, 7:51.

27. Yanqing He, Longping Zhang, Jian Zhang*,Jie Bao*. Helically agitated mixing in dry dilute acid pretreatment enhances the bioconversion of corn stover into ethanol.Biotechnology for Biofuels 2014, 7:1.

28. Hanqi Gu, Jian Zhang, Jie Bao*. Inhibitor analysis and adaptive evolution of Saccharomyces cerevisiae for simultaneous saccharification and ethanol fermentation from industrial waste corncob residues. Bioresource Technology, 2014, 157:6-13.

29. QiuqiangGao, Zhenyang Cui, Jian Zhang, Jie Bao*. Lipid fermentation of corncob residues hydrolysate by oleaginous yeast Trichosporon cutaneum. Bioresource Technology 2014, 152:552-556.

30. LihaoGuo, Jian Zhang, Fengxian Hu, Dewey DY Ryu, Jie Bao*. Consolidated bioprocessing of highly concentrated Jerusalem artichoke tubers for simultaneous saccharification and ethanol fermentation. Biotechnology and Bioengineering 2013, 110:2606-2615.

31. Hongwei Dong, Liqiang Fan, Zichen Lu, JianjiangZhong, Dewey D. Y. Ryu, Jie Bao*. Improvement of ethanol productivity and energy efficiency by degradation of inhibitors using recombinant Zymomonas mobilis (pHW20a-fdh). Biotechnology and Bioengineering 2013, 110:2395-2404.

32. Thai Ha Dao, Jian Zhang, Jie Bao*. Characterization of inulin hydrolyzing enzyme(s) in commercial glucoamylases and its application in lactic acid production from Jerusalem artichoke tubers (Jat). Bioresource Technology2013, 148:157-162.

33. Jian Zhang, Zhenhong Fang, Hongbo Deng, Xiaoxi Zhang, Jie Bao*. Cost analysis of cassava cellulose utilization scenarios for ethanol production on flowsheet simulation platform. Bioresource Technology2013, 134:298-306.

34. Kai Zhao, QinganQiao, Deqiang Chu, HanqiGu, Thai Ha Dao, Jian Zhang, JieBao*. Simultaneous saccharification and high titer lactic acid fermentation of cornstover using a newly isolated lactic acid bacterium Pediococcus acidilactici DQ2. Bioresource Technology2013, 135:481-489.

35. Kehong An, Fengxian Hu, Jie Bao*. Simultaneous saccharification of inulin and starch using commercial glucoamylase and the subsequent bioconversion to high titer sorbitol and gluconic acid. Applied Biochemistry and Biotechnology2013, 171:2093-2104.

36. Wei Liu, Yumei Wang, Zhanchun Yu, Jie Bao*. Simultaneous saccharification and microbial lipid fermentation of corn stover by oleaginous yeast Trichosporon cutaneum.Bioresource Technology2012,118:13-14.

37. Jian Zhang, Jie Bao*. A modified method for calculating practical ethanol yield at high lignocellulosic solids content and high ethanol titer.Bioresource Technology 2012,116:74-79.

38. Deqiang Chu, Jian Zhang, Jie Bao*. Simultaneous saccharification and ethanol fermentation of corn stover at high temperature and high solids loading by a thermotolerant strain Saccharomyces cerevisiae DQ1.Bioenergy Research2012,5:1020-1026.

39. Deqiang Chu, Hongbo Deng, Xiaoxi Zhang, Jian Zhang, Jie Bao*. A simplified filter Paper assay method of cellulase enzymes based on HPLC analysis.Applied Biochemistry and Biotechnology 2012, 167:190-196.

40. Jianming Liu, XiujuanXin, Chunxiu Li, JianheXu, Jie Bao*.Cloning of thermostable cellulase genes of Clostridium thermocellumand their secretive expression in Bacillus subtilis. Applied Biochemistry and Biotechnology  2012,166:652-662.

41. Jian Zhang, Xin Ren, Wenqun Chen, Jie Bao*.Biological pretreatment of corn stover by solid state fermentation of Phanerochaetechrysosporium.Frontier of Chemical Science and Engineering2012,6:146-151.

42. Yumei Wang, Wei Liu, Jie Bao*. Repeated batch fermentation with water recycling and cell separation for microbial lipid production. Frontier of Chemical Science and Engineering 2012, 6(4):453-460.

43. Xiao Huang, Yumei Wang, Wei Liu, Jie Bao*.. Biological removal of inhibitors leads to the improved lipid production in the lipid fermentation of corn stover hydrolysate by Trichosporon cutaneum. Bioresource Technology2011, 102:9705-9709.

44. Jian Zhang, Xiusheng Wang, Deqiang Chu, Yanqing He, Jie Bao*. Dry pretreatment of lignocellulose with extremely low steam and water usage for bioethanol production. Bioresource Technology 2011, 102:4480-4488.

45. Hongwei Dong, Jie Bao*, Dewey D. Y. Ryu*, JianjiangZhong*. Design and construction of improved new vectors for Zymomonas mobilis recombinants. Biotechnology and Bioengineering2011, 108:1616-1627.

46. Dexi Bi, Deqiang Chu, Pei Zhu, Chenyang Lu, Chao Fan, Jian Zhang, Jie Bao*. Utilization of dry distiller’s grain and soluble as trient supplement in the simultaneous saccharification and ethanol fermentation at high solids loading of corn stover.Biotechnology Letter 2011, 33:273-276.

47. Xiusheng Wang, Andong Song, Jie Bao*.Effect of calcium carbonate in waste office paper on enzymatic hydrolysi efficiency and the enhancement procedures. Korea Journal of Chemical Engineering2011, 28:550-556.

48. Hongwei Dong, Jie Bao*. Biofuel via biodetoxification (News and Views). Nature Chemical Biology2010,6:316-318.

49. Jian Zhang, Deqiang Chu, Juan Huang, Zhanchun Yu, Gance Dai, Jie Bao*. Simultaneous saccharification and ethanol fermentation at high corn stover solids loading in a helical stirring bioreactor. Biotechnology and Bioengineering 2010, 105:718-728.

50. Jian Zhang, Zhinan Zhu, Xiaofeng Wang, Nan Wang, Wei Wang, Jie Bao*. Biodetoxification of toxins generated from lignocellulose pretreatment using a newly isolated fungus Amorphotheca resinae ZN1 and the consequent ethanol fermentation.Biotechnology for Biofuels2010,3:26.

51. Changjun Liu, Hongwei Dong, JianjiangZhong, Dewey DY Ryu, Jie Bao*. Sorbitol production using recombinant Zymomonas mobilis strain. Journal of Biotechnology 2010,148:105-112.

52. Zhinan Zhu, JipingShi, ZhihuaZhou, FengxianHu, JieBao*. Photo-fermentationof Rhodobactersphaeroides for hydrogenproductionusinglignocellulose-derived organicacids.ProcessBiochemistry 2010,45:1894-1898.