Qiang Hua

Qiang Hua, Professor

State Key Laboratory of Bioreactor Engineering (SKLBE)

130 Meilong Road,Shanghai, 200237, China

Phone: 021-64250972

Email: qhua@ecust.edu.cn

2008-            Professor, SKLBE,EastChinaUniversityof Science andTechnology,China

2007-2008    Scientist, Sanford-Burnham Medical Research Institute,La Jolla,CA

2004-2007    Research Scholar, Department of Bioengineering,UniversityofCalifornia,San Diego,CA

2001-2004    Assistant Professor, Institute for Advanced Biosciences,Keio University,Japan

2000      Ph.D., Biosciences and Bioinformatics, Kyushu Institute ofTechnology, Japan

1996      M.S., Biochemical Engineering,Zhejiang University,China

1993      B.S., Biochemical Engineering,Zhejiang University,China

Current Research

    Dr. Hua's primary research interests are in advanced technologies in metabolic engineering and systems biotechnology, including isotope-based quantification and analysis of cellular metabolic pathways, reconstruction, simulation and design of metabolic networks. Current research is focused on an integrated metabolic engineering platform for understanding and improving the production of useful metabolites, including anti-cancer secondary metabolites and terpenoids.

Recent Publications

Gu DQ, et al. Reframed genome-scale metabolic model to facilitate genetic design and integration with expression data. IEEE/ACM Transactions on Computational Biology and Bioinformatics, DOI: 10.1109/TCBB.2016.2576456.

Wei SS, et al. Reconstruction of genome-scale metabolic model of Yarrowia lipolytica and its application in overproduction of triacylglycerol. Bioresources and Bioprocessing, 4:51, 2017.

Cao X, et al. Enhancing linalool production by engineering oleaginous yeast Yarrowia lipolytica. Bioresource Technology, 245(B):1641-1644, 2017.

Jian XX, et al. Model-guided identification of novel gene amplification targets for improving succinate production in Escherichia coli NZN111. Integrative Biology, 9:830-835, 2017.

Zhao C, et al. Metabolomic changes and metabolic responses to expression of heterologous biosynthetic genes for lycopene production in Yarrowia lipolytica. Journal of Biotechnology, 251(3):174-185, 2017.

Zhao MJ, et al. Effects of methylmalonyl-CoA metabolic pathway on ansamitocin production in Actinosynnema pretiosum. Applied Biochemistry and Biotechnology, 181(3):1167-1178, 2017.

Jian XX, et al. In silico profiling for cell growth and succinate production in Escherichia coli NZN111. Bioresources and Bioprocessing, 3:48, 2016.

Cao X, et al. Metabolic engineering of oleaginous yeast Yarrowia lipolytica for limonene overproduction. Biotechnology for Biofuels, 9:214, 2016.

Yang X, et al. Heterologous production of α-farnesene in metabolically engineered strains of Yarrowia lipolytica. Bioresource Technology, 216:1040-1048, 2016.

Jian XX, et al. In silico identification of gene amplification targets based on analysis of production and growth coupling. Biosystems, 145:1-8, 2016.

Fan YX, et al. Effects of modulation of pentose-phosphate pathway on biosynthesis of ansamitocins in Actinosynnema pretiosum. Journal of Biotechnology, 230:3-10, 2016.

Zhang C, et al. Investigating the combinatory effects of biological networks on gene co-expression. Frontiers in Physiology, 7:160, 2016.

Gu DQ, et al. IdealKnock: A framework for efficiently identifying knockout strategies leading to targeted overproduction. Computational Biology and Chemistry, 61:229-237, 2016.

Fan YX, et al. Enhancement of UDPG synthetic pathway improves ansamitocin production in Actinosynnema pretiosum. Applied Microbiology and Biotechnology, 100:2651-2662, 2016.

Zhang C, et al. Applications of genome-scale metabolic models in biotechnology and systems medicine. Frontiers in Physiology, 6:413, 2016.

Nambou K, et al. Flux balance analysis inspired bioprocess upgrading for lycopene production by a metabolically engineered strain of Yarrowia lipolytica. Metabolites, 5(4):794-813, 2015.

Zhang C, et al. Logical transformation of genome-scale metabolic models for gene level applications and analysis. Bioinformatics, 31(14):2324-2331, 2015.

Zhao C. et al. Metabolome analysis and pathway abundance profiling of Yarrowia lipolytica cultivated on different carbon sources. Journal of Biotechnology, 206:42-51, 2015.

Li TL, et al. Improvement of ansamitocin P-3 production by Actinosynnema mirum with fructose as the sole carbon source. Applied Biochemistry and Biotechnology, 175(6):2845-2856, 2015.

Zhang C, et al. Logical transformation of genome-scale metabolic models for gene level applications and analysis. Bioinformatics, 31(14):2324-2331, 2015.

Zhao C, et al. Metabolome analysis and pathway abundance profiling of Yarrowia lipolytica cultivated on different carbon sources. Journal of Biotechnology, 206:42-51, 2015.

Fan YX, et al. Process optimization with alternative carbon sources and modulation of secondary metabolism for enhanced ansamitocin P-3 production in Actinosynnema pretiosum. Journal of Biotechnology, 192:1-10, 2014.

Nambou K, et al. Designing of a “cheap to run” fermentation platform for an enhanced production of single cell oil from Yarrowia lipolytica DSM3286 as a potential feedstock for biodiesel. Bioresource Technology, 173: 324-333, 2014.

Wei LJ, et al. Revealing in vivo glucose utilization of Gluconobacter oxydans 621H Δmgdh strain by mutagenesis. Microbiological Research, 169:469-475, 2014.

Gao Y, et al. Enhancement of ansamitocin P-3 production in Actinosynnema pretiosum by a synergistic effect of glycerol and glucose. Journal of Industrial Microbiology & Biotechnology, 41(1):143-152, 2014.