Jiangchao Qian

CreatedTime：2018-09-06 10:09:00

Jiangchao Qian, Ph.D

Professor

130 Meilong Road, Xuhui District, Shanghai.

Phone: 86-21-64250736

Email: jiangchaoqian@ecust.edu.cn

Education

1992 B.A. Biochemical engineering, ECUST

1995 M.S. Biochemistry, ECUST

1999 Ph.D. Biochemical engineering, ECUST

Professional Experience

2011.09~ now: Professor, ECUST

2006.09~ 2011.08: Associate professor, ECUST

2005.10~ 2006.08: Assistant professor, ECUST

2003.09~ 2005.09: Postdoctoral researcher, University of Pennsylvania

1995.07~ 2003.08: Research Associate /Assistant professor, ECUST

Research Interests

1. Metabolic engineering: Modulation and optimization of metabolic pathways in microbial cells to produce protein and metabolite.

2. Nanotechnology and biomaterials: Use and understanding of interactions at the nano-bio interface to guide targeted drug delivery for cancer.

Selected Publications

1. Wu YQ, Tang W, Wang P, Liu CS, Yuan Y*, Qian JC*. Cytotoxicity and cellular uptake of amorphous silica nanoparticles in human cancer cells. Part. Part. Syst. Charact., 2015, 32(7): 779-787.

2. Tang W, Yuan Y, Liu CS, Wu YQ, Lu X, Qian JC*. Differential cytotoxicity and particle action of hydroxyapatite nanoparticles in human cancer cells. Nanomedicine, 2014, 9(3): 397-412.

3. Yao GF, Qin XL, Chu J, Wu XL, Qian JC*. Expression, purification and characterization of a recombinant methionine adenosyltransferase pDS16 in Pichia pastoris. Appl. Biochem. Biotech., 2014, 172(3): 1241-1253.

4. Nie YS, Huang MZ*, Lu JJ, Qian JC, Lin WL, Chu J, Zhuang YP, Zhang SL. Impacts of high β-galactosidase expression on central metabolism of recombinant Pichia pastoris GS115 using glucose as sole carbon source via 13C metabolic flux analysis. J. Biotechnol., 2014, 187: 124-134.

5. Liang T, Qian JC, Yuan Y*, Liu CS*. Synthesis of mesoporous hydroxyapatite nanoparticles using a template-free sonochemistry-assisted microwave method. J. Mater. Sci., 2013, 48 (5): 5334–5341.

6. Chu J*, Qian JC, Zhuang YP, Zhang SL, Li YR. Progress in the research of S-adenosyl-L-methionine production. Appl. Microbiol. Biotechnol., 2013, 97 (1): 41-49.

7. Qin XL, Qian JC*, Xiao CY, Zhuang YP, Zhang SL, Chu J*. GAP promoter library for fine-tuning gene expression in Pichia pastoris. Appl. Environ. Microb., 2011, 77(11): 3600-3608.

8. Qin XL, Qian JC*, Xiao CY, Zhuang YP, Zhang SL,Chu J*. Reliable high-throughput approach for screening of engineered constitutive promoters in the yeast Pichia pastoris. Lett. Appl. Microbiol. 2011, 52(6): 634-641.

9. Lu X, Qian JC, Zhou HJ, Gan Q, Tang W, Lu JX, Yuan Y*, Liu CS*. In vitro cytotoxicity and apoptosis-induction of silica nanoparticles in human hepatoma HepG2 cells. Int. J. Nanomed., 2011, 6: 1889-1901.

10. Wu JQ, Zhang QL, Deng W, Qian JC, Zhang SL, Liu W*. Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination. Appl. Environ. Microb., 2011, 77 (21): 7508-7516.

11. Gan Q, Lu XY, Yuan Y*, Qian JC, Zhou HJ, Lu X, Shi JL, Liu CS*. A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles- capped mesoporous silica. Biomaterials, 2011, 32 (7): 1932-1942.

12. Qian JC, Qin XL, Yin Q, Chu J, Wang YH*. Cloning and characterization of Kluyveromyces marxianus Hog1 gene. Biotechnol. Lett. 2010, 33(3): 571-575.

13. Zhang QL, Wu JQ, Qian JC*,Chu J, Zhuang YP, Zhang SL, Liu W*. Knocking out of tailoring genes eryK and eryG in an industrial erythromycin-producing strain of Saccharopolyspora erythraea leading to overproduction of erythromycin B, C, and D at different conversion ratios. Lett. Appl. Microbiol. 2010, 52: 129-137.

14. Zhao QH, Qian JC*, Zhou HJ, Yuan Y, Mao YH, Liu CS*. In vitro osteoblast-like and endothelial cells' response to calcium silicate/calcium phosphate cement. Biomed. Mater. 2010, 5(3): 035004.

15. Zhang SL*,Cao XJ,Chu J, Qian JC, Zhuang YP. Bioreactors and Bioseparation, Biotechnology in China: Chemicals, Energy & Envronment. Advances in Biochemical Engineering-Biotechnology, 2010, 122: 105-150.

16. Zou X*, Zeng W, Chen CF, Qi XC, Qian JC, Chu J, Zhuang YP, Zhang SL, Li WJ. Fermentation optimization and industrialization of recombinant Saccharopolyspora erythraea strains for improved erythromycin A production. Biotechnol. Bioproc. E, 2010, 15 (6): 959-968.

17. Hu H, Qian JC*,Chu J*, Wang Y, Zhuang YP, Zhang SL. DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-L-methionine production in Pichia pastoris. J. Biotechnol., 2009, 141(3-4): 97-103.

18. Hu H, Qian JC*,Chu J*, Wang YH, Zhuang YP, Zhang SL. Optimization of L-Methionine feeding strategies for improving S-adenosyl-Lmethionine production by methionine adenosyltransferase overexpressed Pichia pastoris. Appl. Microbiol. Biotechnol., 2009, 83(6): 1105-1114.

19. Zhou HJ, Qian JC, Wang J, Yao WT, Liu CS*, Chen JG andCao XH.Enhancedbioactivity of bone morphogenetic protein-2 with low dose of 2-N, 6-O-sulfated chitosan in vitro and in vivo. Biomaterials, 2009, 30 (9): 1715-1724.

20. Chen Y, Deng W, Wu JQ, Qian JC,Chu J, Zhuang YP, Zhang SL*, Liu W*. Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation. Appl. Environ. Microb., 2008, 74 (6): 1820-1828.

21. Qian JC, Lavker RM, Tseng H*. Mapping ribosomal RNA transcription activity in the mouse eye. Dev. Dynam. 2006, 235(7): 1984-1993.

22. Qian JC*, Cai XP,Chu J, Zhuang YP, Zhang SL. Nucleotide mutations in purA gene and pur operon promoter discovered in guanosine- and inosine-producing Bacillus subtilis strains. Biotechnol. Lett. 2006, 28(12 ): 937-941.