Yaling Shen

Yaling Shen, PhD, Professor.

State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology

Research Interests

1. Biotechnology

 Biotechnological process optimization, Biorefinery, Biological Drug’s R&D,    Down-stream process

2. Microbiology

 Microbial metabolic engineering, Quorum sensing, secondary metabolites from microorganisms

Tel: 021-64253156; Fax: 021-64250068; Email: ylshen@ecust.edu.cn

Main Publication

1. Liaoyuan Zhang, Zewang Guo, Jiebo Chen, Quanming Xu, Hui Lin, Kaihui Hu, Xiong Guan & Yaling Shen*, Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241, Sci. Rep. 6, 19257; doi: 10.1038/srep19257 (2016)

2. Jiying Fan, Liying Huang, Jing Sun, Yi Qiu, Jinsong Zhou, Yaling Shen *, Strategy for linker selection to enhance refolding and bioactivity of VAS-TRAIL fusion protein based on inclusion body conformation and activity, Journal of Biotechnology, 2015, 209 , 16–22

3. Fangmin Bai, Lu Dai, Jiying Fan, Ngoctu Truong, Ben Rao,  Liaoyuan Zhang,  Yaling Shen*, Engineered Serratia marcescens for efficient (3R)-acetoin and (2R,3R)- 2,3-butanediol production, Journal of Industrial Microbiology and Biotechnology, 2015, 42(6), 779-786

4. Quanming Xu, Linxiang Xie, Yongyu Li, Hui Lin, Shujing Sun, Xiong Guan, Kaihui Hu, Yaling Shen*, Liaoyuan Zhang*, Metabolic engineering of Escherichia coli for efficient production of (3R)-acetoin, Journal of Chemical Technology and Biotechnology, 2015，90，93–100

5. Liaoyuan Zhang, Quanming Xu, Xiaoqian Peng, Boheng Xu, Yuehao Wu, Yulong Yang, Shujing Sun, Kaihui Hu, Yaling Shen*. Cloning, expression and characterization of glycerol dehydrogenase involved in 2,3-butanediol formation in Serratia marcescens H30. Journal of Industrial Microbiology and Biotechnology， 2014，41(9)，1319–1327

6. Liaoyuan Zhang*, Quanming Xu, Senran Zhan, Hui Lin, Shujing Sun, Li Sha,Xiong Guan, Kaihui Hu, Yaling Shen*，A new NAD(H)-dependent meso-2,3-butanediol dehydrogenase from an industrially potential strain Serratia marcescens H30，Applied Microbiology and Biotechnology，2014，98， 1175-1184

7. Jian-An Sun, Liao-Yuan Zhang, Ben Rao, Ya-Ling Shen* et al, Enhanced acetoin production by Serratia marcescens H32 with expression of a water-forming NADH oxidase，Bioresource Technology，2012，119，94-98

8. Jianan Sun, Ben Rao, Liaoyuan Zhang, Yaling Shen* et al, Extraction of acetoin from fermentation broth using an acetone/phosphate aqueous two-phase system, Chemical Engineering Communications，2012, 199（11）, 1492-1503

9. Jianan Sun，Liaoyuan Zhang, Ben Rao，Yaling Shen* et al，Enhanced acetoin production by Serratia marcescens H32 using statistical optimization and two-stage agitation speed control strategy，Biotechnology and Bioprocess Engineering，2012，17（3），598-605

10. Ben Rao，Liao Yuan Zhang，Jian’an Sun，Yaling Shen* et al，Characterization and regulation of the 2,3-butanediol pathway in Serratia marcescens，Applied Microbiology and Biotechnology，2012，93（5），2147-2159

11. Xiangzhao Mao，Shi Chen，Yaling Shen*，Dongzhi Wei*，Zixin Deng，Effect of copper sulfate on biosynthesis of FR-008/Candicidin complex production in Streptomyces sp.，World Journal of Microbiology and Biotechnology，2011，27（9），2033–2039