第441次SKLBE学术论坛（浙江大学 高海春教授）

以下为第441 次SKLBE学术论坛信息，请阅。

 题目：How nitrite and nitric oxide inhibit bacterial growth: not the same   

 时间：2018-11-23 10:00-11:30

 地点：实验18楼315室

 报告人：浙江大学生命科学学院“”科技创新领军人才 高海春教授

 主持人：王启要教授

摘要： Nitrite has been used in food preservation for centuries because it prevents bacterial growth. About 30 years ago, the effect was proposed to be mediated by nitric oxide (NO), an intermediate formed during nitrite reduction to nitrogen. Ever since, it has become an established theory in nitrite biology. However, by studying Shewanella oneidensis, a Gram-negative bacterium renowned for respiratory versatility, we found that this may not be the case, at least in some bacteria. Nitrite inhibits growth of S. oneidensis under either aerobic or anaerobic conditions. While the cytochrome c oxidase is primarily responsible for nitrite inhibition during oxygen respiration, the answers to inhibition of anaerobic growth are rather complex, involving both global regulator cAMP-Crp and a soluble cytochrome c NapB. In contrast, the targets of NO in bacteria are diverse, with cytochromes c being most vulnerable. 

 

 简历：

 1988.09-1992.06， 北京大学，生物学，  学士

 1992.09-1995.06， 中国科学院武汉病毒研究所，微生物学，硕士

 1997.09-2001.12， 普度大学(美国)，微生物学，博士

 2002.01-2004.12 博士后, 橡树岭国家实验室，美国 

 2005.01-2008.04 研究副教授，密歇根州立和俄克拉荷马大学合作，美国

 2008.05- 教授，浙江大学

 2017   国家“”科技创新领军人才

 

 高海春研究组主要聚焦于系统解析无机和有机物降解模式菌奥内达希瓦氏的环境适应性及机制，主要关注呼吸途径及调控、不良环境应对机制及调控、和单细胞及群体生活方式的选择与调控等方面。以通讯作者身份发表SCI论文80余篇，其中在包括ISME J、Mol Microbiol、Environ Microbiol、J Biol Chem、J Bacteriol、和Appl Environ Microbiol等微生物权威期刊50余篇。研究成果在分子层面上加深了对环境微生物的理解，拓宽了环境微生物研究视野，整体水平居于国际前沿。