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Faculty

Qi Chen

Name: Qi Chen
Title: Postdoc
Phone: +86-21-64250840
Fax: +86-21-64250840
Email: chenq@ecust.edu.cn
Education:
Sep.2003 – July.2007 Jiangsu University of Science and Technology Bachelor's Degree 
2008 – Sep.2009   Ruprecht-Karls-Universität Heidelberg Master’s Degree 
Sep.2007 – July.2013 Shanghai Jiaotong University Doctor's Degree
Sep.2011– Sep.2012  University of Tennessee, Knoxville, and Oak Ridge National Laboratory PHD visiting students of Shanghai Jiao tong University
Academic Positions:
  2016.3- present East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, Lecturer
2013.8- 2016.3 East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, Post-doctor
 
Research:
Molecular dynamic simulation to analysis molecular mechanisms of multi-drug resistance targeting HIV integrase

Molecular mechanism investigation of esterase based on molecular dynamic simulation

Publication:
Journal papers:
1 Wang Z, Chen Q, Liu L. Relationship between topology and functions in metabolic network evolution, Chinese Science Bulletin, 2009, 54(5): 776-782.
2. Chen Q, Wang Z, Wei DQ. Progress in the applications of flux analysis of metabolic networks, Chinese Science Bulletin, 2010, 55: 2315-2322.
3.Chen Q, Zhang T, Wang JF, Wei DQ. Advances in human cytochrome P450 and personalized medicine. Curr Drug Metab. 2011, 12(5):436-444
4. Zhang T, Chen Q, Li L, Liu LA, Wei DQ. In Silico Prediction of Cytochrome P450-Mediated Drug Metabolism. Comb Chem High Throughput Screen. 2011, 14(5):388-395
5. Li L, Chen Q, Wei DQ. Prediction and Functional Analysis of Single Nucleotide Polymorphisms. Curr Drug Metab. 2012, 13: 1012-1023.
6. Chen Q, Buolamwini JK, Smith JC, Li A, Xu Q, Cheng X, Wei DQ. Impact of resistance mutations on inhibitor binding to HIV-1 integrase. J. Chem. Inf. Model., 2013, 53 (12), pp 3297–3307
7. Dou S, Kong XD, Ma BD, Chen Q, Zhang J, Zhou J, Xu JH. Crystal structures of Pseudomonas putida esterase reveal the functional role of residues 187 and 287 in substrate binding and chiral recognition. Biochem Biophys Res Commun. 2014, 446(4):1145-1150.
8. Luo XJ, Kong XD, Zhao J, Chen Q, Zhou J, Xu JH. Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp. Biotechnol Bioeng. 2014, 111(10):1920-1930.
9.Chen Q, Luan ZJ, Cheng X, Xu JH. Molecular dynamics investigation of the substrate binding mechanism in carboxylesterase. Biochemistry. 2015, 54 (9), 1841–1848.
10.Chen Q, Cheng X, Wei DQ, Xu Q. Molecular Dynamics Simulation Studies of the Wild Type and E92Q/N155H Mutant of Elvitegravir resistance HIV-1 integrase. Interdiscip Sci Comput Life Sci. 2015, 7(1):36–42
11.Luan ZJ, Li FL, Dou S, Chen Q, Kong XD, Zhou JH, Yu HL, Xu JH. Substrate channel evolution of an esterase for the synthesis of Cilastatin. Catal. Sci. Technol., 2015, 5(5):2622-2629
12.Jiao XC, Pan J, Xu GC, Kong XD, Chen Q, Zhang ZJ, Xu JH. Efficient synthesis of statin precursor in high space-time yield by a new aldehyde-tolerant aldolase identified from Lactobacillus brevis. Catal. Sci. Technol. 2015, submitted.
13. Chen J, Luo XJ, Chen Q, Pan J, Zhou JH, Xu JH. Markedly enhancement of Acinetobacter sp. organo-phosphotriesterase activity by single substitutation of residue Ile211Ala. Biochem. Bioph. Res. Co. 2015, submitted.
Conference paper:
Monographs
1.Qi Chen and Dongqing Wei. (2014) Chapter 20 Human Cytochrome P450 and Personalized Medicine.Advs Exp. Medicine, Biology Vol. 827, Dongqing Wei et al. (Eds): Advance in Structural Bioinformatics
Achievement:
Funding:
2014.6 The Postdoctoral Science Foundation of China (Grant No. 2014M551349)
2015.1 The Fundamental Research Funds for the Central Universities (Grant No. 22A201514041)
Copyright: 2015 Biocatalysis and Biotechnology Laboratory synthesis Address: Shanghai Mei Long Road 130, 18th Floor, East China University of experiment, 9th Floor, East Email: jianhexu @ ecust. edu.cn      
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