|
|
Faculty
Qi Chen
| Name: Qi Chen | Title: Postdoc | Phone: +86-21-64250840 | Fax: +86-21-64250840 | Email: chenq@ecust.edu.cn |
Education: | Sep.2003 – July.2007 Jiangsu University of Science and Technology Bachelor's Degree | 2008 – Sep.2009 Ruprecht-Karls-Universität Heidelberg Master’s Degree | Sep.2007 – July.2013 Shanghai Jiaotong University Doctor's Degree | Sep.2011– Sep.2012 University of Tennessee, Knoxville, and Oak Ridge National Laboratory PHD visiting students of Shanghai Jiao tong University | Academic Positions: | 2016.3- present East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, Lecturer | 2013.8- 2016.3 East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, Post-doctor |
| Research: | Molecular dynamic simulation to analysis molecular mechanisms of multi-drug resistance targeting HIV integrase | Molecular mechanism investigation of esterase based on molecular dynamic simulation | Publication: | Journal papers: | 1 Wang Z, Chen Q, Liu L. Relationship between topology and functions in metabolic network evolution, Chinese Science Bulletin, 2009, 54(5): 776-782. | 2. Chen Q, Wang Z, Wei DQ. Progress in the applications of flux analysis of metabolic networks, Chinese Science Bulletin, 2010, 55: 2315-2322. | 3.Chen Q, Zhang T, Wang JF, Wei DQ. Advances in human cytochrome P450 and personalized medicine. Curr Drug Metab. 2011, 12(5):436-444 | 4. Zhang T, Chen Q, Li L, Liu LA, Wei DQ. In Silico Prediction of Cytochrome P450-Mediated Drug Metabolism. Comb Chem High Throughput Screen. 2011, 14(5):388-395 | 5. Li L, Chen Q, Wei DQ. Prediction and Functional Analysis of Single Nucleotide Polymorphisms. Curr Drug Metab. 2012, 13: 1012-1023. | 6. Chen Q, Buolamwini JK, Smith JC, Li A, Xu Q, Cheng X, Wei DQ. Impact of resistance mutations on inhibitor binding to HIV-1 integrase. J. Chem. Inf. Model., 2013, 53 (12), pp 3297–3307 | 7. Dou S, Kong XD, Ma BD, Chen Q, Zhang J, Zhou J, Xu JH. Crystal structures of Pseudomonas putida esterase reveal the functional role of residues 187 and 287 in substrate binding and chiral recognition. Biochem Biophys Res Commun. 2014, 446(4):1145-1150. | 8. Luo XJ, Kong XD, Zhao J, Chen Q, Zhou J, Xu JH. Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp. Biotechnol Bioeng. 2014, 111(10):1920-1930. | 9.Chen Q, Luan ZJ, Cheng X, Xu JH. Molecular dynamics investigation of the substrate binding mechanism in carboxylesterase. Biochemistry. 2015, 54 (9), 1841–1848. | 10.Chen Q, Cheng X, Wei DQ, Xu Q. Molecular Dynamics Simulation Studies of the Wild Type and E92Q/N155H Mutant of Elvitegravir resistance HIV-1 integrase. Interdiscip Sci Comput Life Sci. 2015, 7(1):36–42 | 11.Luan ZJ, Li FL, Dou S, Chen Q, Kong XD, Zhou JH, Yu HL, Xu JH. Substrate channel evolution of an esterase for the synthesis of Cilastatin. Catal. Sci. Technol., 2015, 5(5):2622-2629 | 12.Jiao XC, Pan J, Xu GC, Kong XD, Chen Q, Zhang ZJ, Xu JH. Efficient synthesis of statin precursor in high space-time yield by a new aldehyde-tolerant aldolase identified from Lactobacillus brevis. Catal. Sci. Technol. 2015, submitted. | 13. Chen J, Luo XJ, Chen Q, Pan J, Zhou JH, Xu JH. Markedly enhancement of Acinetobacter sp. organo-phosphotriesterase activity by single substitutation of residue Ile211Ala. Biochem. Bioph. Res. Co. 2015, submitted. | Conference paper: | Monographs | 1.Qi Chen and Dongqing Wei. (2014) Chapter 20 Human Cytochrome P450 and Personalized Medicine.Advs Exp. Medicine, Biology Vol. 827, Dongqing Wei et al. (Eds): Advance in Structural Bioinformatics | Achievement: | Funding: | 2014.6 The Postdoctoral Science Foundation of China (Grant No. 2014M551349) | 2015.1 The Fundamental Research Funds for the Central Universities (Grant No. 22A201514041) |
|