| Education： |
| 1981.9~1987.7: BS, Tsinghua University, Beijing China, Chemistry Major |
| 1987.1~1990.7: MS, ECUST, Shanghai China, Physical Chemistry |
| 1990.9~1995.3: Ph. D. ECUST, China and Kyoto Univ, Japan, Chemical Engineering |
| Academic Positions: |
| 1995.04~1996.10: Research Associate, ECUST, Shanghai China. |
| 1996.11~2000.10: Associate Professor, ECUST, Shanghai China |
| 1999.08~2000.04: JSPS Postdoctoral Researcher, with Prof. Yasuhisa Asano, at Center for Biotechnology Research, Toyama Prefectural University, Toyama Japan. |
| 2000.11~present: Professor in Biocatalysis and Bioprocessing, ECUST, Shanghai China. |
| 2002.03~2006.10: Vice Director, State Key Laboratory of Bioreactor Engineering, ECUST. |
| 2003.08~2003.11: Visiting Professor, Supported by DAAD, University of Greifswald,Germany, with Prof. Uwe T. Bornscheuer. |
| 2006.10~present: Vice Dean, School of Biotechnology, ECUST, Shanghai China. |
| 2006.11~present: Director, State Key Laboratory of Bioreactor Engineering, China. |
| 2012.06~present: Director, Shanghai Institute for Biomanufacturing Technology. |
|
| Research： |
| Genomic Mining and Engineering of Industrially Relavant Enzymes; |
| Discovery, Preparation and Characterization of New Enzymes; |
| Immobilization and Repeated Use of Biocatalysts in Bioreactor; |
| Biocatalytic Synthesis of Chiral Chemicals and Natural Products. |
| Publication： |
| Journal papers: |
| 1. Kong XD , Li L, Chen S, Yuan S, Zhou J*, Xu JH*. Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. Proc Natl Acad Sci USA, 2014, 111: 15717–15722 |
| 2. Kong XD , Ma Q, Zhou JH*, Zeng BB*, Xu JH* (2014). A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)--blocker precursors. Angew Chem Int Ed, 2014, 53: 6641–6644. |
| 3. Ma BD , Kong XD, Yu HL*, Zhang ZJ, Dou S, Xu YP, Ni Y, Xu JH*. Increased catalyst productivity in α-hydroxy acids resolution by esterase mutation and substrate modification. ACS Catalysis, 2014, 4: 1026-1031. |
| 4. Luo XJ , Kong XD, Zhao J, Chen Q, Zhou JH*, Xu JH*. Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp. Biotechnology and Bioengineering, 2014, 111: 1920-1930. |
| 5. Nguyen-Tran HH , Zheng GW*, Qian XH, Xu JH*. Highly selective and controllable synthesis of aryl hydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitro reductase BaNTR1. Chemical Communications, 2014, 50: 28612864. |
| 6. Zhang WX , Xu GC, Huang L, Pan J, Yu HL*, Xu JH*. Highly efficient synthesis of (R)-3-quinuclidinol in a space-time yield of 916 g L-1 d-1 using a new bacterial reductase ArQR. Organic Letters, 2013, 15: 49174919. |
| 7. Xu GC , Yu HL*, Zhang ZJ, Xu JH*. Stereocomplementary bioreduction of β‑ketonitrile without ethylated byproduct. Organic Letters, 2013, 15: 5408–5411. |
| 8. Shen ND (沈乃东), Ni Y, Ma HM, Wang LJ, Li CX, Zheng GW, Zhang J, Xu JH*. Efficient synthesis of a chiral precusor for ACE inhibitors in high space-time yield by a new reductase without external cofactors. Organic Letters, 2012, 14: 19821985. |
| 9. Huang L (黄磊), Ma HM, Yu HL*, Xu JH*. Altering the substrate specificity of a reductase CgKR1 by protein engineering for bioreduction of aromatic -ketoesters. Advanced Synthesis and Catalysis, 2014, 356: 1943–1948. |
| 10. Ma HM (马宏敏), Yang LL, Ni Y, Zhang J, Li CX, Zheng GW, Yang HY*, Xu JH*. Stereospecific reduction of methyl o-chlorobenzoylformate at 300 g/L without additional cofactor using a carbonyl reductase mined from Candida glabrata. Advanced Synthesis and Catalysis, 2012, 354: 17651772. |
| Achievement： |
| Funding: |
| Executive Member, Asian Federation of Biotechnology (AFOB). |
| Co-chair, 1st Asian Congress of Biotechnology, Shanghai, 2011. |
| Editor-in-Chief: Bioresources and Bioprocessing (BIOB) (Springer); |
| Associate Editors: Applied Biotechnology and Biotechnology (ABAB); |
| Biotechnology and Bioprocess Engineering (BBEN). |
| Editorial Board Members: Process Biochemistry; Journal of Molecular Catalysis B: Enzymatic; |
| Chinese Journal of Catalysis; Pakistan Journal of Biotechnology. |
| Patent: |
| 30 Chinese Patents: ZL98121942.X；ZL01126617.1；ZL02137019.2; ZL02137019.2; |
| ZL200510027088.7; ZL200410067046.1; ZL200510023852.3; ZL200610082377.1; |
| ZL200610024094.1; ZL200610028357.6; ZL200610147966.3; ZL200610117331.9; |
| ZL200710042880.9; ZL20070040563.3; ZL200780038340.1; ZL200810034069.0; |
| ZL200810042426.8; ZL200810042424.9; ZL200810042425.3; ZL200810040988.9; |
| ZL200910049768.7; ZL200910054358.1; ZL200910045639.0; ZL200910049506.0; |
| ZL200910198764.5; ZL200910247272.0; ZL201010527409.0; ZL201110098532.X; |
| ZL201110091546.9; ZL201110387573.0. |
| PCT Applications: PCT/CN2007/070598; PCT/CN2012/073812. |