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教师

潘江


姓名:潘江
职称:助理研究员
电话:+86-21-6425-0840
传真:+86-21-6425-0840
邮箱:panjiang@ecust.edu.cn
学习经历:
1996.09-2000.07:华东理工大学,本科
2000.09-2003.06:华东理工大学,硕士
2007.09-      :华东理工大学,在职博士
工作经历:
2003.07-2005.05:华东理工大学生物工程学院,助教
2005.05-      :华东理工大学生物工程学院,助理研究员

研究方向:
1. 产酶微生物的筛选,酶的发酵生产
2. 手性化合物的生物催化立体选择性拆分/合成
3. 生物催化过程的规模放大
发表论文:
期刊论文:
1. Zhang ZJ, Pan J, Li CX, Yu HL, Zheng GW, Ju X, Xu JH*. Efficient production of (R)-(-)-mandelic acid using glutaraldehyde cross-linked Escherichia coli cells expressing Alcaligenes sp. nitrilase. Bioprocess & Biosystems Engineering, 2014. 37(7): 1241-1248
2. Zhang Y, Pan J, Luan ZJ, Xu GC, Park S, Xu JH*. Cloning and characterization of a novel esterase from Rhodococcus sp. for highly enantioselective synthesis of a chiral cilastatin precursor. Applied & Environmental Microbiology, 2014. 80(23): 7348-7355
3. Pan J, Zheng GW, Ye Q, Xu JH*. Optimization and scale-up of a bioreduction process for preparation of ethyl (S)-4-chloro-3-hydroxybutanoate. Organic Process Research & Development, 2014. 18(6): 739-743
4. Pan J, Dang ND, Zheng GW, Cheng B, Ye Q, Xu JH*. Efficient production of l-menthol in a two-phase system with SDS using an immobilized Bacillus subtilis esterase. Bioresources and Bioprocessing, 2014. 1: 12
5. Li J, Pan J, Zhang J, Xu JH*. Stereoselective synthesis of L-tert-leucine by a newly cloned leucine dehydrogenase from Exiguobacterium sibiricum. Journal of Molecular Catalysis B-Enzymatic, 2014. 105: 11-17
6. Hu K, Li CX, Pan J, Ni Y, Zhang XY, Xu JH*. Performance of a new thermostable mannanase in breaking guar-based fracturing fluids at high temperatures with little premature degradation. Applied Biochemistry & Biotechnology, 2014. 172(3): 1215-1226
7. Zhou DJ, Pan J, Yu HL, Zheng GW, Xu JH*. Target-oriented discovery of a new esterase-producing strain Enterobacter sp ECU1107 for whole cell-catalyzed production of (2S,3R)-3-phenylglycidate as a chiral synthon of Taxol. Applied Microbiology & Biotechnology, 2013. 97(14): 6293-6300
8. Zhang WX, Xu GC, Huang L, Pan J, Yu HL*, Xu JH*. Highly efficient synthesis of (R)-3-quinuclidinol in a space-time yield of 916 g l-1 d-1 using a new bacterial reductase ArQR. Organic Letters, 2013. 15(19): 4917-4919
9. Ngo-Thi MT, Yin JG, Pan J, Zheng GW*, Xu JH*. Enantioselective hydrolysis of dl-menthyl benzoate by cell-free extract of newly isolated Acinetobacter sp. ECU2040. Applied Biochemistry & Biotechnology, 2013. 170(8): 1974-1981
10. Ma BD, Yu HL*, Pan J, Liu JY, Ju X, Xu JH*. A thermostable and organic-solvent tolerant esterase from Pseudomonas putida ECU1011: Catalytic properties and performance in kinetic resolution of α-hydroxy acids. Bioresource Technology, 2013. 133: 354-360
11. Liu JY, Zheng GW*, Li CX, Yu HL, Pan J, Xu JH*. Multi-substrate fingerprinting of esterolytic enzymes with a group of acetylated alcohols and statistic analysis of substrate spectrum. Journal of Molecular Catalysis B-Enzymatic, 2013. 89: 41-47
12. Liu CH, Pan J, Ye Q, Xu JH*. Enzymatic production of Cilastatin intermediate via highly enantioselective hydrolysis of methyl (±)-2,2-dimethylcyclopropane carboxylate using newly isolated Rhodococcus sp. ECU1013. Applied Microbiology & Biotechnology, 2013. 97(17): 7659-7667
13. Ju X, Yu HL, Pan J*, Xu JH*. Improved production of Pseudomonas sp. ECU1011 acetyl esterase by medium design and fed-batch fermentation. Bioprocess & Biosystems Engineering, 2012. 35(3): 323-331
14. Zheng GW, Yu HL, Li CX, Pan J, Xu JH*. Immobilization of Bacillus subtilis esterase by simple cross-linking for enzymatic resolution of dl-menthyl acetate. Journal of Molecular Catalysis B-Enzymatic, 2011. 70(3-4): 138-143
15. Zhao J, Chu YY, Li AT, Ju X, Kong XD, Pan J, Tang Y, Xu JH*. An unusual (R)-selective epoxide hydrolase with high activity for facile preparation of enantiopure glycidyl ethers. Advanced Synthesis & Catalysis, 2011. 353(9): 1510-1518
16. Zhang ZJ, Pan J, Liu JF, Xu JH*, He YC, Liu YY. Significant enhancement of (R)-mandelic acid production by relieving substrate inhibition of recombinant nitrilase in toluene-water biphasic system. Journal of Biotechnology, 2011. 152(1-2): 24-29
17. Pan J, Kong XD, Li CX, Ye Q, Xu JH*, Imanaka T. Crosslinking of enzyme coaggregate with polyethyleneimine: A simple and promising method for preparing stable biocatalyst of Serratia marcescens lipase. Journal of Molecular Catalysis B-Enzymatic, 2011. 68(3-4): 256-261
18. Pan J, Yu HL, Xu JH, Lin GQ. Advances in biocatalysis: Enzymatic reactions and their applications. Asymmetric catalysis from a chinese perspective, 2011. 36: 67-103
19. Liu JF, Zhang ZJ, Li AT, Pan J, Xu JH*. Significantly enhanced production of recombinant nitrilase by optimization of culture conditions and glycerol feeding. Applied Microbiology & Biotechnology, 2011. 89(3): 665-672
20. Li AT, Zhang JD, Yu HL, Pan J, Xu JH*. Significantly improved asymmetric oxidation of sulfide with resting cells of Rhodococcus sp. in a biphasic system. Process Biochemistry, 2011. 46(3): 689-694
21. Li AT, Yu HL, Pan J, Zhang JD, Xu JH*, Lin GQ. Resolution of racemic sulfoxides with high productivity and enantioselectivity by a Rhodococcus sp. strain as an alternative to biooxidation of prochiral sulfides for efficient production of enantiopure sulfoxides. Bioresource Technology, 2011. 102(2): 1537-1542
22. Zheng GW, Pan J, Yu HL, Ngo-Thi MT, Li CX, Xu JH*. An efficient bioprocess for enzymatic production of l-menthol with high ratio of substrate to catalyst using whole cells of recombinant E. coli. Journal of Biotechnology, 2010. 150(1): 108-114
23. Zhao LL, Pan J, Xu JH*. Efficient production of diltiazem chiral intermediate using immobilized lipase from Serratia marcescens. Biotechnology and Bioprocess Engineering, 2010. 15(2): 199-207
24. Zhang X, Xu JH*, Liu DH, Pan J, Chen B. Construction and operation of a fibrous bed reactor with immobilized lactonase for efficient production of (R)-α-hydroxy-γ-butyrolactone. Biochemical Engineering Journal, 2010. 50(1-2): 47-53
25. Liu X, Xu JH*, Pan J, Zhao J. Efficient production of (S)-naproxen with (R)-substrate recycling using an overexpressed carboxylesterase BsE-NP01. Applied Biochemistry & Biotechnology, 2010. 162(6): 1574-1584
26. Ju X, Yu HL, Pan J, Wei DZ, Xu JH*. Bioproduction of chiral mandelate by enantioselective deacylation of α-acetoxyphenylacetic acid using whole cells of newly isolated Pseudomonas sp. ECU1011. Applied Microbiology & Biotechnology, 2010. 86(1): 83-91
27. Chang L, Ouyang LM, Xu Y, Pan J, Xu JH*. Highly enantioselective hydrolysis of phenyl-1,2-ethanediol cyclic carbonates by newly isolated Bacillus sp. ECU0015. Journal of Molecular Catalysis B-Enzymatic, 2010. 66(1-2): 95-100
28. Zhu H, Pan J, Hu B, Yu HL, Xu JH*. Immobilization of glycolate oxidase from Medicago falcata on magnetic nanoparticles for application in biosynthesis of glyoxylic acid. Journal of Molecular Catalysis B-Enzymatic, 2009. 61(3-4): 174-179
29. Hu B, Pan J, Yu HL, Liu JW, Xu JH*. Immobilization of Serratia marcescens lipase onto amino-functionalized magnetic nanoparticles for repeated use in enzymatic synthesis of Diltiazem intermediate. Process Biochemistry, 2009. 44(9): 1019-1024
30. Zhao LL, Xu JH*, Zhao J, Pan J, Wang ZL. Biochemical properties and potential applications of an organic solvent-tolerant lipase isolated from Serratia marcescens ECU1010. Process Biochemistry, 2008. 43(6): 626-633
31. Yang W, Xu JH*, Pan J, Xu Y, Wang ZL. Efficient reduction of aromatic ketones with NADPH regeneration by using crude enzyme from Rhodotorula cells and mannitol as cosubstrate. Biochemical Engineering Journal, 2008. 42(1): 1-5
32. Ou L, Xu Y, Ludwig D, Pan J, Xu JH*. Chemoenzymatic deracemization of chiral secondary alcohols: Process optimization for production of (R)-1-indanol and (R)-1-phenylethanol. Organic Process Research & Development, 2008. 12(2): 192-195
33. He YC, Xu JH*, Pan J, Ouyang LM, Xu Y. Preparation of (R)-(-)-mandelic acid and its derivatives from racemates by enantioselective degradation with a newly isolated bacterial strain Alcaligenes sp. ECU0401. Bioprocess & Biosystems Engineering, 2008. 31(5): 445-451
34. Zhang X, Xu JH*, Xu Y, Pan J. Isolation and properties of a levo-lactonase from Fusarium proliferatum ECU2002: a robust biocatalyst for production of chiral lactones. Applied Microbiology & Biotechnology, 2007. 75(5): 1087-1094
35. Long ZD, Xu JH*, Zhao LL, Pan J, Yang S, Hua L. Overexpression of Serratia marcescens lipase in Escherichia coli for efficient bioresolution of racemic ketoprofen. Journal of Molecular Catalysis B-Enzymatic, 2007. 47(3-4): 105-110
36. Long ZD, Xu JH*, Pan J. Immobilization of Serratia marcescens lipase and catalytic resolution of trans-3-(4'-methoxyphenyl)glycidic acid methyl ester. Chinese Journal of Catalysis, 2007. 28(2): 175-179
37. Long ZD, Xu JH*, Pan J. Significant improvement of Serratia marcescens lipase fermentation by optimizing medium, induction and oxygen supply. Applied Biochemistry & Biotechnology, 2007. 142(2): 148-157
38. He YC, Xu JH*, Xu Y, Ouyang LM, Pan J. Biocatalytic synthesis of (R)-(-)-mandelic acid from racemic mandelonitrile by a newly isolated nitrilase-producer Alcaligenes sp. ECU0401. Chinese Chemical Letters, 2007. 18(6): 677-680
39. Xu W, Xu JH*, Pan J, Gu Q, Wu XY. Enantioconvergent hydrolysis of styrene epoxides by newly discovered epoxide hydrolases in mung bean. Organic Letters, 2006, 8(8): 1737-1740
40. Huang HR, Xu JH*, Xu Y, Pan J, Liu X. Preparation of (S)-mandelic acids by enantioselective degradation of racemates with a new isolate Pseudomonas putida ECU1009. Tetrahedron-Asymmetry, 2005, 16(12): 2113-2117
41. Xu Y, Xu JH*, Pan J, Zhao L, Zhang SL. Biocatalytic resolution of nitro-substituted phenoxypropylene oxides with Trichosporon loubierii epoxide hydrolase and prediction of their enantiopurity variation with reaction time. Journal of Molecular Catalysis B-Enzymatic, 2004, 27(4-6): 155-159
42. Xu Y, Xu JH*, Pan J, Tang YF. Biocatalytic resolution of glycidyl aryl ethers by Trichosporon loubierii: cell/substrate ratio influences the optical purity of (R)-epoxides. Biotechnology Letters, 2004, 26(15): 1217-1221
43. Chen Y, Xu JH*, Pan J, Xu Y, Shi JB. Catalytic resolution of (RS)-HMPC acetate by immobilized cells of Acinetobacter sp. CGMCC 0789 in a medium with organic cosolvent. Journal of Molecular Catalysis B-Enzymatic, 2004, 30(5-6): 203-208
44. Pan J, Xu JH*. Marked enhancement of epoxide hydrolase production from Trichosporon loubierii ECU1040 by substrate induction and fed-batch fermentation. Enzyme and Microbial Technology, 2003, 33(4): 527-533
45. Yang S, Zhou LP, Tang HX, Pan J, Wu XJ, Huang H, Yuan ZY*. Rational design of a more stable penicillin G acylase against organic cosolvent. Journal of Molecular Catalysis B-Enzymatic, 2002, 18: 285-290
46. 王永红,夏建业,唐寅,杭海峰,易小萍,潘江,许建和,张嗣良。生物反应器及其研究技术进展。生物加工过程,2013,11(2):14-23
47. 赵晶,鞠鑫,潘江,李春秀,王敏杰,许建和。毛白杨环氧水解酶的异源表达及其在催化拆分手性环氧化物中的应用。催化学报,2012,33(2);302-307
48. 林康,陈欣宁,李素霞,许建和,潘江。响应面法优化脂肪酶活性包涵体固定化条件。食品与药品,2012,14(1):1-5
49. 林康,李素霞*,许建和,潘江。戊二醛固定化脂肪酶活性包涵体的性质研究。中国药学杂志,2011,46(15):1150-1153
50. 林康,李素霞*,许建和*,潘江。戊二醛交联法固定化脂肪酶活性包涵体的研究。食品与药品,2011,13(5):153-156
51. 潘江,许建和*,叶勤。地尔硫卓手性中间体合成进展。生物加工过程,2009,7(3):9-15
52. 周冬杰,欧阳立明*,许建和,周鹏鹏,潘江。土壤中腈水解酶产生菌的快速筛选。华东理工大学学报:自然科学版,2009,35(4):545-548
53. 张仙,潘江,许建和*。内酯酶产生菌的筛选及其催化拆分手性内酯的性能。催化学报,2008,29(10):997-1002
54. 倪燕,徐毅,杨巍,潘江,许建和*。树脂吸附对红酵母催化苯乙酮不对称还原反应的促进作用.有机化学,2008,28(12);2137-2141
55. 鞠鑫,潘江,许建和*。绿豆环氧水解酶催化对硝基苯乙烯氧化物的对映归一性水解。催化学报,2008,29(8):696-700
56. 龙章德,许建和*,潘江。粘质沙雷氏菌脂肪酶的固定化及催化拆分反式3-(4’-甲氧苯基)缩水甘油酸甲酯。催化学报,2007,28(2):175-179
57. 黄汉荣,潘江,徐毅,许建和*。恶臭假单胞菌CGMCC 1388对映选择性生物降解制备(S)-扁桃酸及其衍生物的研究。生物加工过程,2005,3(3):47-51
58. 陈亚,许建和*,潘江,徐毅。水-有机溶剂介质中固定化不动杆菌细胞催化拆分(RS)-环戊烯酮乙酸酯的研究。生物加工过程,2004,2(4):22-25
59. 徐毅,潘江,许建和*。环氧水解酶催化合成(R)-和(S)-普萘洛尔。石油化工,2004,(z1):950-952
专著
1. 许建和、潘江、武慧渊。氧化酶。《生物催化工程》第11章。华东理工大学出版社,许建和 主编,出版日期:2008年10月
2. 潘江、许建和。环氧水解酶。《生物催化工程》第14章。华东理工大学出版社,许建和 主编,出版日期:2008年10月
3. 潘江、许建和。酶法拆分手性环氧化物。《生物催化工艺学》第21章。化学工业出版社,孙志浩 主编,出版日期:2004年12月
研究成果:
近年主持的科研项目:

1. 上海市科研项目,心脑血管药物氯吡格雷的绿色化学-酶法偶联合成技术,课题编号:11431921600,2011.11-2014.09
2. 863计划,生物催化合成芳香手性醇基内酰胺,课题编号:2007AA02Z225,2007.07-2010.12
3. 863计划,生物催化还原制备手性芳基醇的关键技术研究,课题编号:2006AA02Z205,2006.01-2008.12
4. 973计划,生物催化和生物转化中关键问题的基础研究,课题编号:2003CB716008,2003.01-2007.12
5. 上海市科研项目,酶法制备地尔硫卓手性前体,课题编号:05DZ19350,2005.12-2007.11
6. 上海市科研项目,酶法合成手性环氧中间体,课题编号:02QMF1412,2002-2005
获奖:
1. 许建和、林国强、李祖义、刘幽燕、潘江、徐毅。新型高效生物催化剂的发现、性能及用于手性化工过程的方法研究。教育部自然科学奖二等奖,2007年。
2. 陆帮荣、许建和、俞宏峰、潘江、邵孟巍、杨慧慧。新型酶制剂及酶促生产医药中间体。常州市科学技术奖二等奖,2010年
版权所有:2015年   生物催化与合成生物技术研究室    地址:上海市梅陇路130号华东理工大学实验18楼9楼东   Email:jianhexu@ecust.edu.cn
电话:+86-21-6425-0840    技术支持:上海屹超信息技术有限公司