陈琦

	姓名：陈琦
	职称：讲师
	电话：021-64250840
	传真：021-64250840
	邮箱：chenq@ecust.edu.cn

学习经历：

2003.9-2007.7    江苏科技大学    学士学位

2008.9-2009.9    德国海德堡大学  硕士学位

2007.9-2013.7    上海交通大学    博士学位

2011.9-2012.9    美国田纳西大学/橡树岭国家实验室 博士生访学

工作经历：

2013.8-今  华东理工大学 生物工程学院生物反应器工程国家重点实验室 师资博士后

研究方向：

分子动力学模拟HIV-1病毒整合酶活性位点内抑制剂以及病毒耐药性变异的结构机理

酯酶催化机理及理性设计研究

发表论文：

期刊论文：

1 Wang Z, Chen Q, Liu L. Relationship between topology and functions in metabolic network evolution, Chinese Science Bulletin, 2009, 54(5): 776-782.

2. Chen Q, Wang Z, Wei DQ. Progress in the applications of flux analysis of metabolic networks, Chinese Science Bulletin, 2010, 55: 2315-2322.

3.Chen Q, Zhang T, Wang JF, Wei DQ. Advances in human cytochrome P450 and personalized medicine. Curr Drug Metab. 2011, 12(5):436-444

4. Zhang T, Chen Q, Li L, Liu LA, Wei DQ. In Silico Prediction of Cytochrome P450-Mediated Drug Metabolism. Comb Chem High Throughput Screen. 2011, 14(5):388-395

5. Li L, Chen Q, Wei DQ. Prediction and Functional Analysis of Single Nucleotide Polymorphisms. Curr Drug Metab. 2012, 13: 1012-1023.

6. Chen Q, Buolamwini JK, Smith JC, Li A, Xu Q, Cheng X, Wei DQ. Impact of resistance mutations on inhibitor binding to HIV-1 integrase. J. Chem. Inf. Model., 2013, 53 (12), pp 3297–3307

7. Dou S, Kong XD, Ma BD, Chen Q, Zhang J, Zhou J, Xu JH. Crystal structures of Pseudomonas putida esterase reveal the functional role of residues 187 and 287 in substrate binding and chiral recognition. Biochem Biophys Res Commun. 2014, 446(4):1145-1150.

8. Luo XJ, Kong XD, Zhao J, Chen Q, Zhou J, Xu JH. Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp. Biotechnol Bioeng. 2014, 111(10):1920-1930.

9.Chen Q, Luan ZJ, Cheng X, Xu JH. Molecular dynamics investigation of the substrate binding mechanism in carboxylesterase. Biochemistry. 2015, 54 (9), 1841–1848.

10.Chen Q, Cheng X, Wei DQ, Xu Q. Molecular Dynamics Simulation Studies of the Wild Type and E92Q/N155H Mutant of Elvitegravir resistance HIV-1 integrase. Interdiscip Sci Comput Life Sci. 2015, 7(1):36–42

11.Luan ZJ, Li FL, Dou S, Chen Q, Kong XD, Zhou JH, Yu HL, Xu JH. Substrate channel evolution of an esterase for the synthesis of Cilastatin. Catal. Sci. Technol., 2015, 5(5):2622-2629

12.Jiao XC, Pan J, Xu GC, Kong XD, Chen Q, Zhang ZJ, Xu JH. Efficient synthesis of statin precursor in high space-time yield by a new aldehyde-tolerant aldolase identified from Lactobacillus brevis. Catal. Sci. Technol. 2015, submitted.

13. Chen J, Luo XJ, Chen Q, Pan J, Zhou JH, Xu JH. Markedly enhancement of Acinetobacter sp. organo-phosphotriesterase activity by single substitutation of residue Ile211Ala. Biochem. Bioph. Res. Co. 2015, submitted.

会议论文：

专著

1.Qi Chen and Dongqing Wei. (2014) Chapter 20 Human Cytochrome P450 and Personalized Medicine.Advs Exp. Medicine, Biology Vol. 827, Dongqing Wei et al. (Eds): Advance in Structural Bioinformatics

研究成果：

近年主持的科研项目：

2014.6 中国博士后科学基金第55批面上资助。

2015.1 2015年度华东理工大学基本科研业务费探索研究基金。