刘润辉

发布时间：2020-09-14 11:09:00

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主要研究方向:

模拟天然蛋白功能的合成高分子生物材料，包括：
1. 功能化聚合物单体的合成；多功能高分子材料的制备及合成方法研究
2. 生物相容、生物可降解高分子材料的研究与开发
3. 抗细菌、抗真菌生物材料的研制与作用机理研究
4. 具有细胞黏附、细胞选择功能的生物材料研究及在组织修复中的应用
5. 抗非特异性蛋白吸附及微生物生物膜形成的防污材料研究及在生物医学工程领域的应用
6. 蛋白类及小分子药物的体内传输和可控释放研究

7. 抗肿瘤多肽研究

代表性学术论文:

20. Chen, Q.; Zhang, D.; Zhang, W.; Zhang H.; Zou, J.; Chen, M.; Li, J.; Yuan, Y.*.; Liu, R.*Dual mechanismβ-amino acid polymers promoting cell adhesion. Nature Communications 2021, 12, 562

19. Zhang, D.; Chen, Q.; Shi, C.; Chen, M.; Ma, K.; Wan, J.; Liu, R.* Dealing with the Foreign-Body Response to Implanted Biomaterials: Strategies and Applications of New Materials. Adv. Funct. Mater. DOI: 10.1002/adfm.202007226.

18. Etayash, H.; Qian, Y.; Pletzer, D.; Zhang, Q.; Xie, J.; Cui, R.; Dai, C.; Ma, P.; Qi, F.; Liu, R.* Hancock, R. E. W.* Host Defense Peptide-Mimicking Amphiphilic beta-Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and in Vivo Anti-Infective Activity. J. Med. Chem. 2020, 63, 12921-12928.

17. Zhang, D.; Chen, Q.; Zhang, W.; Liu, H.; Wan, J.; Qian, Y.; Li, B.; Tang, S.; Liu, Y.; Chen, S.; Liu, R.* Silk‐inspired β‐peptide Materials Resist Fouling and the Foreign‐body Response. Angew. Chem. Int. Ed. 2020, 59, 9586–9593.

16. Zhou, M.; Xiao, X.; Cong, Z.; Wu, Y.; Zhang, W.; Ma, P.; Chen, S.; Zhang, H.; Zhang, D.; Zhang, D.; Luan, X.; Mai, Y.; Liu, R.* Water Insensitive Synthesis of Poly-beta-Peptides with Defined Architecture. Angew. Chem. Int. Ed. 2020,59, 7240-7244.

15. Zhou, M.; Qian, Y.; Xie, J.; Zhang, W.; Jiang, W.; Xiao, X.; Chen, S.; Dai, C.; Cong, Z.; Ji, Z.; Shao, N.; Liu, L.; Wu, Y.; Liu, R.* Poly(2‐Oxazoline) Based Functional Mimics of Peptides to Eradicate MRSA Infections and Persisters While Alleviating Antimicrobial Resistance. Angew. Chem. Int. Ed. 2020, 59, 6412-6419.

14. Chen, Q.; Yu, S.; Zhang, D.; Zhang, W.; Zhang, H.; Zou, J.; Mao, Z.; Yuan, Y.; Gao C.; Liu, R.* Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors. J. Am. Chem. Soc. 2019, 141, 16772

(Selected as the JACS supplementary cover paper)

(Highlighted by Sci. China Chem, 2019, DOI: 10.1007/s11426-019-9654-9)

(Highlighted by CCL, 2019, DOI: 10.1016/j.cclet.2019.10.038)

13. Wu, Y.; Zhang, D.; Ma, P.; Zhou, R.; Hua, L.; Liu, R.* Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides. Nat. Commun. 2018, 9 (1), 5297.

(Selected as the editor's choice)

(Spotlight by Acta Polymerica Sinica, 2019, 50(2): 99)

(Spotlight by J. Functional Polymers, 2019, 32(2): 120)

(Spotlight reviewed by Materials Reports, 2019, 33(1): 1)

12. Ding, X.; Duan, S.; Ding, X.; Liu, R.*; Xu, F.*, Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens. Adv. Funct. Mater. 2018, 28 (40), 19.

11. Qi. F; Qian, Y.; Shao, N.; Zhou, R.; Zhang, S.; Lu Z.; Zhou, M.; Xie, J.; Wei, T.; Yu, Q.;, Liu, R.*, Practical Preparation of Infection-Resistant Biomedical Surfaces from Antimicrobial β-Peptide Polymers. ACS Appl. Mater. Interfaces 2019, 11 (21), 18907-18913.

10. Qian, Y.; Qi, F.; Chen, Q.; Zhang, Q.; Qiao, Z.; Zhang, S.; Wei, T.; Yu, Q.; Yu, S.; Mao, Z.; Gao, C.; Ding, Y.; Cheng, Y.; Jin, C.; Xie, H.; Liu, R.* Surface Modified with a Host Defense Peptide-Mimicking beta-Peptide Polymer Kills Bacteria on Contact with High Efficacy. ACS Appl. Mater. Interfaces 2018, 10 (18), 15395-15400.

9. Liu, R.; Chen, X.; Falk, S.; Masters, K. S.; Weisblum, B.; Gellman, S. H. “Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms” J. Am. Chem. Soc. 2015, 137: 2183-2196.

8. Liu, R.; Chen, X.; Falk, S.; Mowery, B.; Karlsson, A.; Weisblum, B.; Palecek, S.; Masters, K. S.; Gellman, S. H. “Structure–Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active Against Drug-Resistant Strains of Candida albicans”, J. Am. Chem. Soc.2014, 136: 4333-4342.

(Highlighted by SciBX, SciBX 7(11), 2014, 315)

7. Liu, R.; Chen, X.; Chakraborty, S.; Lemke, J.; Hayouka, Z.; Chow, C.; Welch, R.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern”, J. Am. Chem. Soc.2014, 136: 4410-4418.

(Highlighted by SciBX: SciBX 7(15), 2014, 441)

6. Liu, R.#; Suárez, J. M.#; Weisblum, B.; Gellman, S. H.; and McBride, S. M. “Polymers Active Against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth.” J. Am. Chem. Soc. 2014, 136, 14498-14504. (equal contribution)

(Highlighted by SciBX: SciBX 7(43), 2014, 1263)

5. Chakraborty, S.#; Liu, R.#; Hayouka, Z.; Chen, X.; Ehrhardt, J.; Lu, Q.; Burke, E.; Yang, Y.; Weisblum, B.; Wong, G. C. L.; Masters, K. S; and Gellman, S. H. “Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.” J. Am. Chem. Soc.2014, 136, 14530-14535. (equal contribution)

4. Liu, R.; Chen, X.; Gellman, S. H.; Masters, K. S. “Nylon-3 Polymers that Enable Selective Culture of Endothelial Cells”, J. Am. Chem. Soc. 2013, 135: 16296-16299.

3. Liu, R.; Chen, X.; Hayouka, Z.; Chakraborty, S.; Falk, S. P.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Nylon-3 Polymers with Selective Antifungal Activity.” J Am Chem Soc. 2013, 135, 5270-5273.

(Featured in JACS Spotlights,J. Am. Chem. Soc. 2013, 135: 5933−5933)

2. Hayouka, Z.; Chakraborty, S.; Liu, R.; Boersma, M. D.; Weisblum, B.; Gellman, S. H. “Interplay among Subunit Identity, Subunit Proportion, Chain Length, and Stereochemistry in the Activity Profile of Sequence-Random Peptide Mixtures.” J. Am. Chem. Soc. 2013, 135: 11748-11751.

1. Liu, R.; Chanthamontri, C.; Han, H.; Hernández-Torres, J.M.; Wood, K.V.; Mcluckey, S.A.; Wei, A. “Solid-Phase Synthesis of α-Glucosamine Sulfoforms with Fragmentation Analysis by Tandem Mass Spectrometry.” J. Org. Chem. 2008, 73: 6059-6072.