程侠卫

发布时间：2020-09-08 10:09:00

程侠卫 研究员

程侠卫华东理工大学药学院、生物反应器工程国家重点实验室、光遗传学和合成生物学交叉学科研究中心成员。发现并命名自噬调控蛋白Pacer，并揭示Pacer作为一个新的代谢感受器调控自噬体和溶酶体融合的功能和分子机制；于2019年加入华东理工大学光遗传学和合成生物学交叉学科研究中心，从事细胞自噬和细胞代谢的研究工作。目前在Molecular Cell (2017, 2019), Autophagy (2019) , Theranostics (2019) 和Science (2020)等国际核心期刊发表论文多篇。主持完成国家自然科学基金青年科学基金项目及多项省部级项目。

The long-term goal of his research is to discover the relationship between cell autophagy and cell metabolism and develop potential therapeutic drugs for metabolic diseases base on cell autophagy.

ØAutophagy, central carbon metabolism and metabolic diseases.

ØRegulation mechanism of autophagy pathway on cell metabolism

ØMolecular mechanism of cell metabolites regulating autophagy

1. Cheng Xiawei; Ma Xiuling; Ding Xingming; Li Lin; Jiang Xiao; Chen She; Shen Zhirong; Liu Wei; Gong Weihua*; Sun Qiming. Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17, Molecular Cell, 2017, 65(6): 1029-1043.

2. Cheng Xiawei; Ma Xiuling; Zhu Qi; Song Dandan; Ding Xianming; Li Lin; Jiang Xiao; Wang Xinyi; Tian Rui; Su Hua; Shen Zhirong; Chen She; Liu Ting; Gong Weihua; Liu Wei; Sun Qiming. Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism, Molecular Cell, 2019, 73(4): 788-802.

3. Cheng Xiawei; Sun Qiming. RUBCNL/Pacer and RUBCN/Rubicon in regulation of autolysosome formation and lipid metabolism, Autophagy, 2019, 15(6): 1120-1121.

4. Liu Chen#; Cheng Xiawei#; Chen Juntao; Wang Yao; Wu Xiaoying; Tian Rui; Liu Baoqing; Ding Xianfeng; Sun Qiming*; Gong Weihua*; Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration, Theranostics, 2019, 9(13):3840-3852.

5. Lu Yan, Zheng Yuping, Coyaud Etienne,Zhang Chao, Selvabaskaran, Apiraam, Yu Yuyun; Xu Zizhen; Weng Xialian, Chen JiShun, Meng Ying; Warner Neil; Cheng Xiawei; Liu Yangyang; Yao Bingpeng; Hu Hu; Xia Zonping; Muise Aleixo M; Klip Amira; Brumell, John H; Girardin Stephen E; Ying Songmin; Fairn Gregory D; Raught Brian; Sun Qiming; Neculai Dante; Palmitoylation of NOD1 and NOD2 is required for bacterial sensing , Science, 2019, 366(6464): 460-467.