周胜敏

周胜敏

专业领域：生物化学与分子生物学，生物化工

博士，生物反应器工程国家重点实验室副教授。2009年3月取得日本东京大学博士学位。2009年4月至2014年8月先后在东京大学和日本筑波大学做科研工作。期间2011年4月至 2013年3月任职日本学术振兴会(JSPS)特别研究员。2014年8月回国任教于华东理工大学生物工程学院。

研究内容及今后研究方向

研究领域为环境微生物及工业微生物的分子生物学。探索并解析与微生物抗逆、信号传导及二次代谢调控等相关的诸多功能基因，以期通过活用这些功能基因为生物技术在工业，农业，医疗卫生等领域的应用提供理论指导。长期以来以模型真菌为研究对象，利用分子生物学手段探索了真菌的一氧化氮(NO)抗逆机制，已经鉴定出一系列新型NO抗性功能基因，并解明其抗性原理。这些成果被发表在Nature Chemical Biology, Applied Environmental Microbiology和Fungal Genetics and Biology等微生物学经典杂志上。今后将继续从事与医疗卫生，食品，环境等密切相关的真菌领域的研究，尤其拓展真菌抗逆机制及其信号传导系统领域的研究。拟全面解明真菌的NO抗性及氧化应激抗性机制，找出致命标靶，为开发能够有效协助人体自身免疫系统杀死病原真菌的非抗生素类药物提供理论指导，缓解当下国内由于抗生素滥用而即将面临的无药可救的严峻局面。同时，NO和氧化应激诱发物质H2O2也是所有生物体内重要信号传导物质，解明NO和H2O2在微生物体内信号传导途径不仅能有效指挥微生物在生物技术产业中发挥作用，而且可以为人体内信号传导方式的研究提供重要参考。具体研究方向如下:

1.全面解明真菌的NO抗性机理，定位新型杀菌靶点.

2.解明真菌的氧化应激抗性体系.

3.解明氧化应激在调控丝状真菌次级代谢产物生物合成中的作用及其分子机制.

4.深度解析丝状真菌的NO合成体系及NO信号传导功能.

5. 新型丝状真菌蛋白表达体系的开发

发表论文

(1).Jia Wei, Xiaodan Cao, Shengmin Zhou, Chao Chen, Haijun Yu, Yao Zhou, Ping Wang. Soluble expression and purification of the catalytic domain of human vascular endothelial growth factor receptor 2 in Escherichia coli.Journal of Microbiology and Biotechnology.In press, 2015.

(2). Shunsuke Masuo, Lisa Osada,Shengmin Zhou, Tomoya Fujita,Naoki Takaya. Aspergillus oryzae pathways that convert phenylalanine into the flavor volatile 2-phenylethanol.Fungal Genetics and Biology. 77: 22-30, 2015.

(3). Shengmin Zhouand Naoki Takaya. Novel fungal nitrosothionein peptide involved in tolerance to nitric oxide. Bioscience&industry.72(2): 55-56,2014.

(4).Masanori Toyofuku, Shengmin Zhou, Isao Sawada, Naoki Takaya, Hiroo Uchiyama andNobuhiko Nomura.Membrane vesicle formation is associated with pyocin production under denitrifying conditions in Pseudomonas aeruginosa PAO1. Environmental Microbiology. 16(9):2927-2938,Sep, 2014,

(5).Shengmin Zhou, Toshiaki Narukami, ShunsukeMasuo, Motoyuki Shimizu, Tomoya Fujita, Yuki Doi, Yosuke Kamimura, Naoki Takaya. NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin. Nature Chemical Biology.9(10): 657-663, Aug, 2013.

(6).Tomoya Fujita, HieuDuc Nguyen, Takashi Ito, Shengmin Zhou, Lisa Osada, Seiji Tateyama, Tatsuo Kaneko, Naoki Takaya.Microbial monomers custom-synthesized to build true bio-derived aromatic polymers.Applied Microbiology and Biotechnology.97(20):8887-8894, Aug, 2013.

(7).Wenjing Cui, Xiaoyan Yang, Yueqin Fang,Shengmin Zhou, Song Liu, Guocheng Du, Kun Du, Jian Chen, Guanjun Tao and Zhemin Zhou. Discovery of two transglutaminases derived from same zymogen for the Streptomyces hygroscopicus and analysis of their formation processes.Journal of the Science of Food and Agriculture. 93(7): 1711-1717, May, 2013.

(8).Morio Miyahara, Sang-Wan Kim,Shengmin Zhou, Shinya Fushinobu, Takeshi Yamada, Wakako Ikeda-Ohtsubo, Akira Watanabe, Keisuke Miyauchi, Ginro Endo and Hirofumi Shoun.Survival of the aerobic denitrifier Pseudomonas stutzeri strain TR2 during co-culture with activated sludge under denitrifying conditions.Bioscience, Biotechnology, and Biochemistry. 76(3): 495-500, Mar, 2012.

(9).Shengmin Zhou, Toshiaki Narukami, MisuzuNameki, Tomoko Ozawa, Yosuke Kamimura, Takayuki Hoshino and Naoki Takaya. Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulans from nitrosative stress.Applied and Environmental Microbiology. 78(1): 103-109, Jan, 2012.

(10).Shengmin Zhou,Shinya Fushinobu,Sang-Wan Kim, Yoshito Nakanishi, Jun-ichi Maruyama,  Katsuhiko Kitamoto, Takayoshi Wakagi, and Hirofumi Shoun.Functional analysis and subcellular location of two flavohemoglobins from Aspergillus oryzae.Fungal Genetics and Biology, 48(2): 200-207, Feb, 2011.

(11).Sang-Wan Kim, Shinya Fushinobu,Shengmin Zhou,Takayoshi Wakagi and Hirofumi Shoun.The possible involvement of copper-containing nitrite reductase (NirK) and flavohemoglobin in denitrification by the fungus Cylindrocarpon tonkinense.Bioscience, Biotechnology, and Biochemistry.74 (7): 1403-1407, Jul, 2010.

(12).Shengmin Zhou*, Yoshito Nakanishi*,Shinya Fushinobu, Sang-Wan Kim, Jun-ichi Maruyama, Katsuhiko Kitamoto, Takayoshi Wakagi, and Hirofumi Shoun. A eukaryotic copper-containing nitrite reductase derived from a NirK homolog gene of Aspergillus oryzae.Bioscience, Biotechnology, and Biochemistry.74(5):984-991, May, 2010.Co-first author.

(13).Shengmin Zhou, Shinya Fushinobu, Sang-Wan Kim, Yoshito Nakanishi, TakayoshiWakagi, and Hirofumi Shoun.Aspergillusoryzaeflavohemoglobins promote oxidative damage by hydrogen peroxide. Biochemical and Biophysical Research Communications.394(3):558-561, Apr, 2010.

(14).Sang-Wan Kim, Shinya Fushinobu, Shengmin Zhou, Takayoshi Wakagi, and Hirofumi Shoun.Eukaryotic nirK genes encoding copper-containing nitrite reductase: originating from the protomitochondrion?Applied and Environmental Microbiology. 75 (9): 2652-2658, Mar, 2009.

(15).Shengmin Zhou, Shinya Fushinobu, Yoshito Nakanishi, Sang-Wan Kim, Takayoshi Wakagi and Hirofumi Shoun.Cloning and characterization of two flavohemoglobins from Aspergillus oryzae.Biochemical and Biophysical Research Communications.381 (1): 7-11, Jan, 2009.

申请中专利

4-氨基肉桂算的制造方法。日本，专利申请号2014-021543