郁惠蕾

发布时间：2018-09-05 16:09:00

2008年毕业于华东理工大学生物化工专业，获工学博士学位并获2010年优秀百篇博士论文提名奖。2010年起任华东理工大学生物反应器工程国家重点实验室副研究员，生物催化团队的主要成员之一。2012年赴日本短期学习嗜热微生物的培养，2013年受国家留学基金委资助赴美国麻省理工学院进修一年。主持国家自然科学基金，973子课题和霍英东基金等项目，发表SCI论文40余篇，申请发明专利9项，其中授权中国发明专利3项，公开4项，实现成果转让2项。

研究方向

氧化还原酶的定向挖掘和改造
多酶组合催化体系构建和调控
生物催化制备重要手性中间体

代表性论文和专著

Huang L, Ma HM, Yu HL* and Xu JH*. Altering the substrate specificity of a reductase CgKR1 from Candida glabrata by protein
engineering for bioreduction of aromatic α-keto esters. Adv.Synth.Catal. DOI 10.1002/adsc.201300775
Xu YP, Guan Y H, Yu HL*, Ni Y, Ma BD, Xu JH*. Improved o-chlorobenzoylformate bioreduction by stabilizing aldo-
keto reductase YtbE with additives. J Mol Catal B: Enzymatic http://dx.doi.org/10.1016/j.molcatb.2014.03.006
Ma BD, Kong XD, Yu HL*, Zhang ZJ, Dou S, Xu YP, Ni Y, and Xu JH *. Increased Catalyst Productivity in α-Hydroxy Acids
Resolution by Esterase Mutation and Substrate Modification. ACS Catal. 2014, 4 (3): 1026–1031
Zhang WX, Xu GC, Huang L, Pan J, Yu HL*, Xu JH*. Highly efficient synthesis of (R)-3-quinuclidinol in a space
–time yield of 916 g L –1 d –1 using a new bacterial reductase ArQR. Org. Lett. 2013, 15(19): 4917–4919
Xu GC, Yu HL*, Zhang ZJ, Xu JH*. Stereocomplementary bioreduction of β-ketonitrile without ethylated byproduct. Org. Lett. 2013, 15(21): 5408–5411
Ma BD, Yu HL*, Pan J, Liu JY, Ju X, Xu JH*.A thermostable and organic-solvent tolerant esterase from Pseudomonas putida ECU1011: Catalytic properties and performance in kinetic resolution of alpha-hydroxy acids. Bioresour. Technol. 2013, 133: 354-360
Xu GC, Yu HL*, Zhang XY and Xu JH*. Access to optically active aryl halohydrins using a substrate-tolerant carbonyl reductase discovered from Kluyveromyces thermotolerans. ACS Catal. 2012, 2(12): 2566–2571
Zou ZZ, Yu HL*, Li CX, Zhou XW, Hayashi C, Sun J, Liu BH, Imanaka T, Xu JH*. A new thermostable beta-glucosidase mined from Dictyoglomus thermophilum: Properties and performance in octyl glucoside synthesis at high temperatures.
Bioresour. Technol. 2012, 118: 425-430
Yu HL, Ou L, Xu JH*. New trends in non-aqueous biocatalysis. Curr. Org. Chem. 2010, 14(14): 1424-1432
Yu HL, Xu JH*, Lu WY, Lin GQ. Discovery and utilization of biocatalysts for chiral synthesis: An overview of Chinese scientists research
and development. Adv. Biochem. Eng. Biotechnol. 2009, 113: 1-31
Yu HL, Xu JH*, Lu WY, Lin GQ. Environmentally benign synthesis of natural glycosides using apple seed meal as green and robust biocatalyst.
J. Biotechnol. 2008, 133: 469-477
Yu HL, Xu JH*, Wang YX, Lu WY, Lin GQ. Assembly of a three-dimensional array of glycoconjugates by combinatorial biocatalysis in nonaqueous media. J. Comb. Chem. 2008, 10: 79-87
郁惠蕾, 许建和译校 (许建和、陶军华、林国强主译). 面向制药工业的生物催化—发现、开发及生产. 化学工业出版社. 2010
许建和, 郁惠蕾. 生物催化法合成手性药物及中间体. 见：林国强、王梅祥主编，《手性合成与手性药物》(第2章). 化学工业出版社. 2008

联系方式
上海市梅陇路130号，华东理工大学, 实验18楼911室
电话：021-64250840；传真：021-64252250
华东理工大学283信箱，邮编200237
E-mail: huileiyu@ecust.edu.cn