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尹斌成

发布时间：2018-09-05 16:09:00


 

尹斌成，副教授                                                                                                    


2011年6月毕业于华东理工大学，获工学博士学位。现任职于华东理工大学生物反应器工程国家重点实验室。研究方向是生物分析技术，主要从事生物分析及生物传感技术开发、生物探针设计等分析化学和生命科学交叉领域的基础及应用研究，以解决疾病早期诊断和治疗、食品安全检测、环境污染物检测和非法药物检测等重要课题。近年来在J Am Chem Soc，Angew Chem Int Ed，Anal Chem，Chem Commum，Biosens & Bioelectron，Chem Eur J，ACS Appl Mater Interfaces等国际性刊物上发表SCI收录论文40余篇，申请中国发明专利5项（授权3项），撰写英文专著1部。主持和作为主要成员承担了国家自然科学基金（青年）、国家自然科学基金重点项目，国家863项目、上海市自然科学基金、上海市纳米专项等项目。曾获2008年度上海市技术发明奖二等奖，2009年度明治乳业生命科学奖，2012年度华东理工大学第一届英才计划资助，2013年度上海市研究生优秀成果（学位论文）等奖项。 
论著清单：

  • Jin-Liang Ma, Bin-Cheng Yin,* Huynh-Nhu Le, and Bang-Ce Ye*. Label-Free Detection of Sequence-Specific DNA based on Fluorescent Silver Nanoclusters-Assisted Surface Plasmon Enhanced Energy Transfer.ACS Applied Materials & Interfaces7(23), 12856-12863, 2015.
  • Peng-Qiang Leng,Feng-Lan Zhao, Bin-Cheng Yin,* and Bang-Ce Ye*. A Novel, Colorimetric Method for Biogenic Amine Detection based on Arylalkylamine N-Acetyltransferase. Chemical Communication51, 8712-8714, 2015.
  • Bin-Cheng Yin, Shan Wu, Jin-Liang Ma,and Bang-Ce Ye*. A Novel Molecular Beacon-based Method for Isothermal Detection of Sequence-Specific DNA via T7 RNA Polymerase-Aided Target Regeneration. Biosensors& Bioelectronics68, 365-370, 2015.
  • Cui-Yuan Yu, Bin-Cheng Yin,*Shilong Wang, Zengguang Xu,and Bang-Ce Ye*. Improved Ligation-Mediated PCR Method Coupled with T7 RNA Polymerase for Sensitive DNA Detection. Analytical Chemistry86, 7214-7218, 2014.
  • Bin-Cheng Yin,* Jin-Liang Ma, Huynh-Nhu Le, Shilong Wang, Zengguang Xu, and Bang-Ce Ye*. A New Mode to Light Up Adjacent DNA-Scaffolded Silver Probe Pair and Its Application for Specific DNA Detection. Chemical Communication50 (100), 15991-15994, 2014.
  • Yuan-Chen He, Bin-Cheng Yin,*Lihua Jiang, and Bang-Ce Ye.Rapid Detection of MicroRNA based on p19-Enhanced Fluorescence Polarization. Chemical Communication50 (47), 6236-6239, 2014.
  • Xiaoyan Lin, Liang Cui, Yishun Huang, Ya Lin, Yi Xie, Zhi Zhu*, Bin-Cheng Yin, Xi Chen, and Chaoyong James Yang*. Carbon Nanoparticle-Protected Aptamers for Highly Sensitive and Selective Detection of Biomolecules based on Nuclease-Assisted Target Recycling Signal Amplification.Chemical Communication 50: 7646-7648, 2014.
  • Jin Huang, Yong He, Xiaohai Yang, Kemin Wang, Le Ying, Ke Quan, Yanjing Yang, and Bin-Cheng Yin. I-Motif-Based Nano-Flares for Sensing pH Changes in Live Cells. Chemical Communication 50, 15768-15771, 2014.
  • Bin-Cheng Yin,Yu-Qiang Liu, and Bang-Ce Ye*.Sensitive Detection of MicroRNA in Complex Biological Samples via Enzymatic Signal Amplification Using DNA Polymerase Coupled with Nicking Endonuclease. Analytical Chemistry85 (23), 11487-11493, 2013.
  • Cui-Yuan Yu, Bin-Cheng Yin,* and Bang-Ce Ye*. A Universal Real-Time PCR Assay for Rapid MicroRNA Quantification via the Enhancement of Base-Stacking Hybridization. Chemical Communication 49 (74),8247-8249, 2013.
  • Min Zhang, Yu-Qiang Liu, Cui-Yuan Yu, Bin-Cheng Yin,* and Bang-Ce Ye*. Multiplexed Detection of MicroRNAs by Tuning DNA-Scaffolded Silver Nanoclusters. Analyst 138 (17), 4812- 4817, 2013.
  • Xin-Ping Wang, Bin-Cheng Yin,* and Bang-Ce Ye*. A Novel Fluorescence Probe of dsDNA-Templated Copper Nanoclusters for Quantitative Detection of MicroRNAs. RSC Advances 3, 8633-8636, 2013.
  • Xin-Ping Wang, Bin-Cheng Yin,* Ping Wang, and Bang-Ce Ye*.Highly Sensitive Detection of MicroRNAs based on Isothermal Exponential Amplification-Assisted Generation of Catalytic G-Quadruplex DNAzyme. Biosensors&Bioelectronics 42,131-135, 2013.
  • Min Zhang, Huynh-Nhu Le, Xiao-Qin Jiang, Bin-Cheng Yin,and Bang-Ce Ye*.Time-Resolved Probes Based on Guanine/Thymine-Rich DNA-Sensitized Luminescence of Terbium (III). Analytical Chemistry85 (23),11665-11674, 2013.
  • Bin-Cheng Yin, Yu-Qiang Liu, and Bang-Ce Ye*. One-step, Multiplexed Fluorescence Detection of microRNAs Based on Duplex-Specific Nuclease Signal Amplification. Journal of the American Chemical Society 134 (11), 5064-5067, 2012.
  • Bin-Cheng Yin, Mingxu You, Weihong Tan, Bang-Ce Ye*. Mercury(II) Ions Detection via Pyrene-Mediated Photolysis of Disulfide Bonds. Chemistry - A European Journal 18(5), 1286-1289, 2012.
  • Bin-Cheng Yin, Bang-Ce Ye*, Hui Wang, Zhi Zhu, Weihong Tan*. Colorimetric Logic Gates based on Aptamer-Crosslinked Hydrogel. Chemical Communication 48, 1248-1250, 2012.
  • Bin-Cheng Yin, Yi-Meng Guan, and Bang-Ce Ye*. An Ultrasensitive Electrochemical DNA Sensor based on the ssDNA-assisted Cascade of Hybridization Reaction. Chemical Communication 48 (35), 4208-4210, 2012.
  • Yu-Qiang Liu, Min Zhang, Bin-Cheng Yin, and Bang-Ce Ye*. Attomolar Ultrasensitive MicroRNA Detection by DNA-Scaffolded Silver-Nanocluster Probe based on Isothermal Amplification. Analytical Chemistry 84(12), 5165-5169, 2012.
  • Di Wu, Bin-Cheng Yin, (共同1作) and Bang-Ce Ye*. A Label-Free Electrochemical DNA Sensor based on Exonuclease III-Aided Target Recycling Strategy for Sequence-Specific Detection of Femtomolar DNA. Biosensors& Bioelectronics 28, 232-238, 2011.
  • Mingxu You, Yan Chen, Lu Peng, Da Han, Bin-Cheng Yin, Bang-Ce Ye, and Weihong Tan*. Engineering DNA Aptamers for Novel Analytical and Biomedical Applications. Chemical Science 2, 1003-1010, 2011.
  • Hui-Jie Tong, Na Jin, Bin-Cheng Yin, and Bang-Ce Ye*. A Novel Separation and Enrichment Method of 17β-Estradiol using Aptamer-Anchored Beads. Bioprocess and Biosystems Engineering 34, 189-195, 2011.
  • Min Zhang, Bin-Cheng Yin, Weihong Tan, and Bang-Ce Ye*. A Versatile Graphene-Based Fluorescence “On/Off” Switch for Multiplex Detection of Various Targets. Biosensors& Bioelectronics 26, 3260-3265, 2011.
  • Min Zhang, Bin-Cheng Yin, Xian-Fei Wang, and Bang-Ce Ye*. Interaction of Peptides with Graphene Oxide and Its Application for Real-Time Monitoring of Protease Activity. Chemical Communication 47, 2399-2401, 2011.
  • Bin-Cheng Yin, Min Zhang, Weihong Tan*, and Bang-Ce Ye*. Peptide-Functionalized Spherical Polyelectrolyte Nanobrushes for Real-Time Sensing of Protease Activity. ChemBioChem 11, 494-497, 2010.
  • Bin-Cheng Yin, Peng Zuo, Hao Huo, Xinhua Zhong, and Bang-Ce Ye*. DNAzyme-Self-Assembled Gold Nanoparticles for Determination of Metal Ions using Fluorescence Anisotropy Assay. Analytical Biochemistry 401, 47-52, 2010.
  • Bin-Cheng Yin, Di Wu, and Bang-Ce Ye*. A Sensitive DNA-based Electrochemical Strategy for Trace Bleomycins Detection. Analytical Chemistry 82(19), 8272-8277, 2010.
  • Bin-Cheng Yin, Bang-Ce Ye*, Hui Wang, Weihong Tan*, and Cong-Cong Xie. An Allosteric Dual-DNAzyme Unimolecular Probe for Colorimetric Detection of Copper(II). Journal of the American Chemical Society 131, 14624-14625, 2009.
  • Bin-ChengYin,Xian-Fei Wang, and Ye Bang-Ce*. Multiplex Genotyping and Allele Frequency Estimation using Non-Gel Capillary Electrophoresis. Analytical Biochemistry 387, 221-229, 2009.
  • Peng Zuo, Bin-Cheng Yin,(共同1作) Bang-Ce Ye*. DNAzyme-based Microarray for Highly Sensitive Detection of Metal Ions. Biosensors& Bioelectronics 25, 935-939, 2009.
  • Sheng-Quan Jin, Bin-Cheng Yin, and Bang-Ce Ye*. A Multiplexed Bead-based Mesofluidic System for Foodborne Pathogen Bacteria Detection.Applied and Environmental Microbiology 75, 6647-6654, 2009.
  • Bang-Ce Ye*, Yan Zhang, Hui Yu, Wen-Bang Yu, Bao-Hong Liu, Bin-Cheng Yin, Chun-Yun Yin, Yuan-Yuan Li, Ju Chu, Si-Liang Zhang. Time-resolved Transcriptome Analysis of Bacillus subtilis Responding to Valine, Glutamate, and Glutamine.PLoS ONE 4(9), e7073, 2009.
  • Bang-Ce Ye*, Bincheng Yin. Highly Sensitive Detection of Mercury (II) ion by Fluorescence Polarization via Gold Nanoparticle Enhancement. Angewandte Chemie International Edition 47, 8386-8389, 2008.
  • Bin-Cheng Yin, Honghua Li, and Bang-Ce Ye*. A Dual-Probe Hybridization Method for Reducing Variability in Single Nucleotide Polymorphism Analysis with Oligonucleotide Microarrays. Analytical Biochemistry 383, 270-278, 2008.
  • Bin-Cheng Yin, Honghua Li, and Bang-Ce Ye*. Microarray-based Estimation of SNP Allele-frequency in Pooled DNA using the Langmuir Kinetic Model. BMC Genomics 9, 605, 2008.
  • Bin-Cheng Yin, Fei Yue, and Bang-Ce Ye*. Construction of Microarrays for Genotyping of DQA using Unmodified 45-mer Oligonucleotide. Molecular Biotechnology 36, 142-150, 2007.
  • Bang-Ce Ye, Min Zhang, Bin-Cheng Yin.英文专著《Nano-Bio Probe Design and Its Application for Biochemical Analysis》,施普林格出版社，2012.

专利：

  • 叶邦策，尹斌成，发明专利：管式生物芯片，已授权，ZL200610023184.9
  • 叶邦策，尹斌成，发明专利：纳米粒子强化的荧光偏振分析方法, 已授权， ZL200810041166.2
  • 叶邦策，尹斌成，刘玉强，发明专利：一种利用恒温扩增反应合成荧光纳米银簇探针定量检测microRNA的分析方法，已授权，ZL2001210107456.9
  • 叶邦策，尹斌成，于翠媛，发明专利：定量检测microRNA 的PCR 分析方法，申请号201310291939.3
  • 叶邦策，尹斌成，于翠媛，发明专利：一种RNA聚合酶和连接酶偶联反应介导的定量检测核酸的PCR分析方法，申请号201410317015.0

联系方式 
地址：上海市梅陇路130号华东理工大学实验18楼713室(283信箱)，邮编200237
办公电话：+86-21-64253832
电子邮箱：binchengyin@ecust.edu.cn

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