实验室概况
发布时间:2018-09-05 15:09:00
谢贺新
教授,博导
电话:021-64252269
Email: xiehexin@ecust.edu.cn
地址:上海市徐汇区梅陇路130号实验14楼西501室
个人简介
1998年毕业于上海复旦大学化学系,获理学学士学位。后到中国科学院上海有机化学研究所金属有机国家重点实验室工作。2008年毕业于美国新墨西哥大学化学与化学生物学系,获理学博士学位。2009年至2012年,在美国斯坦福大学医学院分子影像中心(MIPS)从事博士后研究。2013年加入华东理工大学药学院。
研究方向
化学生物学,分子影像学,合成/药物化学
代表性论文
1. Cheng, Y. #; Xie, H.#; Sule, P.; Hassounah, H.; Graviss, E. A.; Kong, Y.; Cirillo, J. D. and Rao, J.* “Fluorogenic Probes with Substitutions at the 2 and 7 Positions of Cephalosporin are Highly BlaC-Specific for Rapid Mycobacterium Tuberculosis Detection” Angew. Chem. Int. Ed.,2014, 53, 9360.(Reported by “Cheap test slashes time taken to diagnose TB”, Nature doi: 10.1038/nature.2014.15503) .
2. Xie, H. #, Mire, J. #, Kong, Y. #, Chang, M., Hassounah, H., Thornton, C.N., Sacchettini, J. C., Cirillo, J. D., Rao, J.* "Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe ", Nature. Chem.2012, 4, 802.(Reported by Nature(doi:10.1038/nature.2012. 11327) and Scientific American).
3. Xie, H.; Zhang, Y.; Zhang, S.; Chen, X. "Bi_functional Cinchona Alkaloid Thiourea Catalyzed Highly Efficient, Enantioselective Aza-Henry Reaction of Cyclic Trifluoromethyl Ketimines: Synthesis of Anti-HIV Drug DPC 083" Angew. Chem. Int. Ed.,2011,50, 11773.
4. Zhang, S.-L. #,Xie, H. #; Zhu, J.; Li, H.; Zhang, X.-S.; Li, J.*, “Organocatalytic enantioselective β-_functionalization of aldehydes by oxidation of enamines and their application in cascade reactions” Nature. Commun. 2011, 2, 211-218. (Reported by C&E News (2011, 89(10), 9), ChemCatChem(2012, 4, 612) and Synfacts(2011, 5, 0560))
5. Xie, H.; Zu, L.; Li, H.; Wang, J. “Organocatalytic Enantioselective Cascade Michael-Alkylation Reactions: Synthesis of Chiral Cyclopropanes and Investigation of Unexpected Organocatalyzed Stereoselective Ring Opening of Cyclopropanes”,J. Am. Chem. Soc., 2007, 129, 10886.