第521次SKLBE学术论坛

题目：Engineering Biology: programming cells to compute, sense and manufacture

报告人：英国爱丁堡大学 王宝俊 教授

时间：2020-11-25 (周三)  13:30-

地点：实验18楼315室

主持人：叶邦策教授

BAOJUN WANG, Ph.D.

G20 Roger Land, School of Biological Sciences, University of Edinburgh, EH9 3FF   baojun.wang@ed.ac.uk

Career and Research Experience

08/2019 – Present          Reader in Synthetic Biology, School of Biological Sciences, University of Edinburgh

05/2019 – present                  UK Research and Innovation Future Leaders Fellow, School of Biological Sciences, University of Edinburgh

07/2013 – 07/2019          Group Leader & Chancellor’s Fellow in Synthetic Biology, University of Edinburgh

04/2011 – 07/2013    Research Associate in Synthetic Biology, Imperial College London

01/2007 – 03/2011    Ph.D. in Bioengineering (synthetic biology), Imperial College London

Education

01/2007 – 01/2011          Ph.D., Department of Bioengineering, Imperial College London, UK  

09/2005 – 11/2006    MSc Diploma in Biomedical Engineering, Zhejiang University, China

09/2000 – 06/2005    B.Eng. in Biomedical Engineering, 1^st class, Zhejiang University, China

Research Areas and Interests

Synthetic Biology and Bioengineering:        Synthetic biology enabling tools; Biological circuit design and engineering; Cell-based/cell-free biosensors for toxins and pathogens; Engineered phage therapeutics for enteric infectious diseases. (Lab:http://wang.bio.ed.ac.uk/)

Selected Publications (* indicates corresponding author)

Wan X, Pinto F, Yu L and Wang B*, “Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity”, Nature Communications, 2020. doi pdf 

Pinto F, Thornton E and Wang B*, “An expanded library of orthogonal split inteins enables modular multi-peptide assemblies”, Nature Communications, 2020, 11, 1529 doi

Hicks M, Bachmann T and Wang B*, “Synthetic biology enables programmable cell-based biosensors”, ChemPhysChem, 2020, 21, 132–144 doi (Featured as Front Cover Article)

Wan X, Volpetti F, Petrova E, French C, Maerkel SJ and Wang B*, “Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals”, Nature Chemical Biology, 2019, 15(5), 540–548 doi  

Liu Y, Wan X and Wang B*, “Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria”,Nature Communications, 2019, 10, 3693 doi

Lopreside A, Wan X, Michelini E, Roda A and Wang B*, “Comprehensive profiling of diverse genetic reporters with application to whole-cell and cell-free biosensors”, Analytical Chemistry, 2019, 91, 15284?15292 doi

Liu Q, Schumacher J, Wan X, Lou C and Wang B*, “Orthogonality and burdens of heterologous AND gate gene circuits in E. coli, ACS Synthetic Biology, 2018, 7(2):553-564 doi

Bradley R, Buck M and Wang B*, “Tools and principles for microbial gene circuit engineering”, Journal of Molecular Biology, 2016, 428(5):862-888 doi

Bradley R, Buck M and Wang B*, “Recognizing and engineering digital-like logic gates and switches in gene regulatory networks”, Current Opinion in Microbiology, 2016, 33:74–82 doi 

Wang B*, Barahona M and Buck M, “Amplification of small molecule-inducible gene expression via tuning of intracellular receptor densities”, Nucleic Acids Research, 2015, 43(3):1955-1964 doi

Wang B*, Barahona M and Buck M, “Engineering modular and tunable genetic amplifiers for scaling transcriptional signals in cascaded gene networks”, Nucleic Acids Research, 2014, 42(14): 9484-9492

doi   (Reported by Imperial College Science News)

Wang B* and Buck M, “Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules”, Chemical Communications, 2014, 50(79):11642-44 doi (Front Cover Article)

Wang B*, Barahona M and Buck M, “A modular cell-based biosensor using engineered genetic logic circuits to detect and integrate multiple environmental signals”, Biosensors and Bioelectronics, 2013, 40, 368-376    doi

Wang B* and Buck M, “Customizing cell signaling using engineered genetic logic circuits”, Trends in Microbiology, 2012, 20(8): 376-384         doi

Wang B, Kitney R, Joly N and Buck M, “Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology”, Nature Communications, 2011, 2:508        doi

Selected Prizes and Awards

2020    Elected Fellow of the Royal Society of Chemistry (FRSC), Royal Society of Chemistry

2019    UKRI Future Leaders Fellowship, UK Research and Innovation

2017    SB7.0 Biosecurity Fellowship, The BioBricks Foundation, USA

2016    BBSRC New Investigator Award, Biotechnology and Biological Sciences Research Council

2016    Wellcome Seed Award in Science, Wellcome Trust

2015    Grand Challenges Explorations Award, Bill and Melinda Gates Foundation

2013    Chancellor’s Fellowship in Synthetic Biology, The University of Edinburgh

Selected Current/Related Research Grants

05/2019 – 05/2023   PI of UKRI Future Leaders Fellowship award (£1.56 million, MR/S018875/1) 

Project: Engineering orthogonal split inteins as scalable tools for synthetic biology & biomanufacturing

01/2021 – 12/2023   PI of Leverhulme Trust research project grant (£360k, RPG-2020-241)

Project: Distributed cell-consortia biocomputers with scalable signal processing capacity

09/2020 – 09/2023   PI of US Office of Naval Research Global grant award ($390k, N62909-20-1-2036)

Project: 3D printed wearable biosensors for noninvasive sweat-based health monitoring

07/2016 – 06/2019   PI of BBSRC New Investigator award (BB/N007212/1, £433k) 

Project: Enabling synthetic biology with an expanded library of engineered orthogonal genetic switches

Selected Invited Oral Presentations

11/2020      ‘The Future of Intelligent Sensing and Measurement’ Symposium, University of Glasgow

09/2020      Biological and Physiological Monitoring and Modeling Program 2020 Review Meeting, ONRG

11/2019      Warwick Integrative Synthetic Biology Centre Seminar, University of Warwick

09/2019      NII Shonan Meeting on "Formal methods for the synthesis of biomolecular circuits", Japan

05/2019      DSTL Synthetic Biology Showcase Conference, Williams F1 Conference Centre, Oxford

11/2018      Synthetic Biology UK 2018 Congress, London, organized by Oxford Global

06/2018      Biosensors 2018 – 28^th Anniversary World Congress on Biosensors (950+ attendees), Miami,

06/2017      UK Centre for Doctoral Training in Synthetic Biology Conference, University of Oxford

03/2017      Contributing solutions to a global crisis: Launch of the Edinburgh AMR Strategy, Edinburgh

09/2016      Unlocking the potential of synthetic biology to enhance human health, London

07/2016      Society of Experimental Biology Annual Main Meeting, Brighton

05/2016      Biosensors 2016 – 14^th World Congress on Biosensors (1200+ attendees), Gothenburg.

07/2014      16^th European Congress on Biotechnology (800+ attendees), Edinburgh, organized by EFB.

05/2012      Keynote talk at Biosensors 2012 World Congress on Biosensors (700+ attendees), Cancun.

05/2010      Keynote talk at Biosensors 2010 World Congress on Biosensors (1000+ attendees), Glasgow.