第520次SKLBE学术论坛

题目1：人类管控疾病威胁努力的现状：挑战和应对

报告人：中国科学技术大学附属第一医院 朱景德 教授

时间：2020-11-10 (周二)  15:00-16:00

地点：实验18楼315室

主持人：赵玉政教授

报告人简介:

朱景德教授，1984年得英国格拉斯哥大学博士学位，1985年担任中国科学院上海细胞所生命科学开放实验室副主任；1990年在英国ChesterBeatty癌症研究所，英国格拉斯哥大学，Beatson癌症研究所，英国Cyclacel，Ltd公司和英国格拉斯哥大学生化系担任相关课题组的负责人。2001-2014年在上海交通大学癌基因及相关基因国家重点实验室工作，2012年至今担任中科大附一院安徽省肿瘤医院肿瘤表观遗传学实验室主任。

目前致力于高效溶瘤腺病毒药物产业化和临床应用。肿瘤基础和转化医学研究和推动国际和地区的表观遗传组学研究以外，通过主办高品质的表观遗传学，瘤转化医学，数学肿瘤学，昼夜节律疾病和集智同行等高品质学术会议，推动高学科跨度，多学科整合，针对重大生物医学问题的系统研究。共发表包括在Cell， Nature Biotech在内的 SCI杂志上论文60余篇，获得美国专利3个，国内专利4个。担任过国际表观遗传组学，AACR表观遗传组专家成员，亚洲表观遗传组学联盟创建人。

题目2：The mechanical clues during the initiation of B cell activation

报告人：清华大学 刘万里 教授

时间：2020-11-10(周二）16:00-17:00

地点：实验18楼315室

主持人：赵玉政 教授

报告人简介:

刘万里，清华大学生命学院长聘教授，博士生导师，清华大学免疫所、生命科学联合中心研究员。获基金委杰青、科技部万人计划领军人才、中国青年科技奖、药明康德生命化学杰出成就奖、谈家桢生命科学创新奖、树兰医学青年奖等。研究成果入选2018年度中国十大医学科技新闻。获得基金委重点项目、NFSC-NIH多年期项目、创新群体项目、科技部863计划青年科学家项目和973项目等支持。

聚焦B淋巴细胞基础免疫学研究，致力于整合交叉学科平台以对B细胞免疫识别、免疫活化及相关免疫疾病的致病机理进行研究。在B细胞异常活化与相关疾病（Science、J Exp Med、Cell Research、Leukemia两篇、JACI和eLife 2019a）、脂类代谢网络调控B细胞活化新机制（Cell、Science Immunology、Cell Reports和Nature Communications两篇）、抗原受体复合物微簇体调控B细胞活化新机制（Science Advances、PNAS和eLife 2019b）和机械力感知系统调控B细胞活化新机制（J Cell Biol、Science Signaling和eLife两篇）等研究方向发表通讯作者论文（含共同通讯）。受邀撰写综述（Cell Research、Trends ln Immunology、Advances in Immunology、Cellular Immunology和Immunological Review等）。

 代表性论文（*通信作者，#co-first author）：

[1]       Xingwang Zhao^#, Hengyi Xie^#, Meng Zhao^#, Asma Ahsan, Xinxin Li, Fei Wang, Junyang Yi, Zhiyong Yang, Chuan Wu, Indu Raman, Quan-Zhen Li*, Tae Jin Kim*, Wanli Liu*. Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and _function. Science Advances. 2019, 5, eaaw0315, DOI: 10.1126/sciadv.aaw0315

[2]       Zhixun Shen^#, Sichen Liu^#, Xinxin Li^#, Zhengpeng Wan, Youxiang Mao, Chunlai Chen, Wanli Liu*. Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding. eLife. 2019, 8, doi: 10.7554/eLife.42271.

[3]       Chenguang Xu^#, Yan Fang^#, Zhiyong Yang, Yukai Jing, Yonghui Zhang, Chaohong Liu*, Wanli Liu*. MARCKS regulates tonic and chronic active B cell receptor signaling. Leukemia. 2019, 33:710-729.

[4]       Xiangjun Chen, Xiaolin Sun^#, Wei Yang^#, Bing Yang^#, Xiaozhen Zhao, Shuting Chen1, Lili He, Hui Chen, Changmei Yang, Le Xiao, Zai Chang, Jianping Guo, Jing He, Fuping Zhang, Fang Zheng, Zhibin Hu, Zhiyong Yang, Jizhong Lou, Wenjie Zheng, Hai Qi, Chenqi Xu, Hong Zhang, Hongying Shan, Xu-jie Zhou, Qingwen Wang, Yi Shi, Luhua Lai, Zhanguo Li *,Wanli Liu*. An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation. Science. 2018, 362:700-705.

[5]       Yun Xia^#, Yonghua Xie^#, Zhengsen Yu^#, Hongying Xiao, Guimei Jiang, Xiaoying Zhou, Yunyun Yang, Xin Li, Meng Zhao, Liping Li, Mingke Zheng, Shuai Han, Zhaoyun Zong, Xianbin Meng, Haiteng Deng, Huahu Ye, Yunzhi Fa, Haitao Wu, Eric Oldfield, Xiaoyu Hu, Wanli Liu*, Yan Shi*, Yonghui Zhang*. The mevalonate pathway is a druggable target for vaccine adjuvant discovery. Cell. 2018, 175:1059-1073.

[6]       Junyi Wang^#, Feng Lin^#, Zhengpeng Wan, Xiaolin Sun, Yun Lu, Jianyong Huang, Fei Wang, Yingyue Zeng, Ying-Hua Chen, Yan Shi, Wenjie Zheng, Zhanguo Li, Chunyang Xiong*, Wanli Liu*. Profiling the origin, dynamics, and _function of traction force in B cell activation. Science Signaling. 2018, 11. pii: eaai9192. doi: 10.1126/scisignal.aai9192. (Cover story)

[7]       Zhengpeng Wan, Chenguang Xu^#, Xiangjun Chen^#, Hengyi Xie^#, Zongyu Li^#, Jing Wang^#, Xingyu Ji, Haodong Chen, Qinghua Ji, Samina Shaheen, Yang Xu, Fei Wang, Zhuo Tang, Ji-Shen Zheng, Wei Chen, Jizhong Lou, Wanli Liu*. PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation. J Cell Biol. 2018, 217:2565-2582.

[8]       Chenguang Xu, Hengyi Xie, Xingdong Guo, Haipeng Gong, Lei Liu, Hai Qi, Chenqi Xu, Wanli Liu*. A PIP2-derived amplification loop fuels the sustained initiation of B cell activation. Science Immunology. 2017, 2. pii: eaan0787. doi: 10.1126/sciimmunol.aan0787.

[9]       Liling Xu^#, Mengdie Xia^#, Jun Guo^#, Xiaolin Sun^#, Hua Li, Chenguang Xu, Xiaomei Gu, Haowen Zhang, Junyang Yi, Yan Fang, Hengyi Xie, Jing Wang, Zhixun Shen, Boxin Xue, Yujie Sun, Tobias Meckel, Ying-Hua Chen, Zhibin Hu, Zhanguo Li*, Chenqi Xu*, Haipeng Gong*, Wanli Liu*. Impairment on the lateral mobility induced by structural changes underlies the _functional deficiency of the lupus-associated polymorphism FcγRIIB-T232. J Exp Med. 2016, 213:2707-2727.

[10]   Jing Wang^#, Shan Tang^#, Zhengpeng Wan, Yiren Gao, Yiyun Cao, Junyang Yi, Yanyan Si, Haowen Zhang, Lei Liu* andWanli Liu*. Utilization of a photoactivatable antigen system to examine B cell probing termination and the B cell receptor sorting mechanisms during B cell activation. PNAS. 2016, 113:E558-567.

[11]   Zhengpeng Wan, Xiangjun Chen, Haodong Chen, Qinghua Ji, Yingjia Chen, Jing Wang, Yiyun Cao, Fei Wang, Jizhong Lou, Zhuo Tang and Wanli Liu*. The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold. eLife. 2015, 4:e06925 (Faculty of 1000 recommended paper)

[12]   Xiangjun Chen^#, Weiling Pan^#, Yinqiang Sui, Hua Li, Xiaoshan Shi, Xingdong Guo, Hai Qi, Chenqi Xu* and Wanli Liu*. Acidic phospholipids govern the enhanced activation of IgG-B cell receptor. Nature Communications. 2015, 6:8552.