第492次SKLBE学术论坛（美国华盛顿大学 Rong Tian教授）

题目：  Metabolism and Cell Growth

报告人：  美国华盛顿大学 Rong Tian教授

时间：   2019-11-1（周五）15:00-16:00

地点：   实验18楼420室

主持人：  杨弋教授

Abstract:

Metabolism plays a crucial role in regulating cell growth.  Most of the studies so far focused on proliferating cells such as cancer or stem cell.    Less is known about post mitotic cells such as cardiomyocytes.  Hypertrophic growth of cardiomyocytes is a key feature of pathological remodeling of the diseased heart, which ultimately leads to heart failure. It is increasingly recognized that metabolic reprogramming of the heart is integral to the development of heart failure. Cardiac

hypertrophy is associated with significant changes in substrate metabolism including increased reliance on glucose and ketone bodies and reduced catabolism of fatty acids and branched amino acids. While the switch from fatty acids to glucose has been shown ultimately maladaptive for energy supply, the impact of increased glucose reliance on cardiac hypertrophy and remodeling is incompletely understood. Emerging results suggest that changes in glucose and branched

chain amino acid metabolism, apart from their contribution to energy production, serve multiple roles in controlling the hypertrophic growth of the heart.  The talk will evaluate the impact of substrate switch on energy production in the heart by comparing and contrasting the contribution of a variety of substrates using bioengineered mouse models.  The main focus will be the role of substrate metabolism in signal transduction and biosynthetic function of the cardiomyocytes undergoing hypertrophic growth.