第463次 SKLBE学术论坛(美国斯克里普斯研究所 吴鹏 副教授)

题目：A sweet way to boost the efficacy of cell-based cancer immunotherapy

报告人：美国斯克里普斯研究所吴鹏 副教授

时间：2019-4-19  14:30-

地点：实验18楼315室

主持人：张立新教授

报告人简介：

吴鹏 副教授2005年在Scripps研究所取得化学博士学位，师从2001年诺贝尔化学奖得主K. Barry Sharpless教授。2005年至2008年，吴鹏博士在加州大学伯克利分校 (UC Berkeley) 美国科学院院士, 霍德华休斯研究会(HHMI) 研究员Carolyn R. Bertozzi教授实验室从事博士后研究工作。他将自己感兴趣的生物正交化学和生物技术结合，开发了一种用基因编码的醛基标签对单克隆抗体进行位点特异性修饰的方法。吴博士是SMARTag? technology 四个发明者之一。 2014年该专利被Catalent Biologics收购。2016年Catalent与Roche就该技术签订$6.18亿美元合作协议。吴鹏博士从事化学和生物学交叉领域的研究。目前聚焦于开发新工具用于研究蛋白质糖基化，特别是与感染性疾病和癌症相关的蛋白质糖基化。这些新工具用于改造T细胞，提高其活性进行免疫治疗。

Biography

Peng Wu is an Associate Professor in the Department of Molecular Medicine at The Scripps Research Institute. Before joining the faculty at TSRI, Peng was an Associate Professor of Biochemistry and the Scientific Director of the Chemical Biology Core Facility at Albert Einstein College of Medicine, New York.

Peng Wu received his doctorate from TSRI in 2005 under the guidance of Professor K. Barry Sharpless. From 2005 to 2008, Peng was a postdoctoral fellow in the group of Professor Carolyn R. Bertozzi at the University of California, Berkeley. There, he combined his interests in bioorthogonal chemistry and biotechnology by developing a method for site-specific modification of monoclonal antibodies using a genetically-encoded aldehyde tag.

The research in the Wu laboratory integrates synthetic chemistry with glycobiology to explore the relevance of protein glycosylation in human disease and host-symbiont interactions. The major goal of the laboratory is to develop chemical biology platforms to image and characterize the glycome in tumors and in the immune system. The laboratory is also interested in chemical tools that enable selectively enrichment of glycoproteins in leukocytes for their molecular identification and functional studies.

A sweet way to boost the efficacy of cell-based cancer immunotherapy

 Explore the promiscuity of glycosylation enzymes to boost the efficacy of cancer immunotherapy.