以下为第418次SKLBE 学术论坛暨加拿大皇家科学院院士Hancock教授受聘我校荣誉教授仪式信息,请阅。
报告题目: Alternatives to Antibiotics for treating Multidrug Resistant Infections
报告人: 加拿大皇家科学院院士Hancock教授
时间: 2018-6-6 10:00-11:30
地点: 逸夫楼演讲厅
Short biography
1975, Ph.D., University of Adelaide
1977, Postdoctoral Fellow., University of Tubingen, Germany
1978, Postdoctoral Fellow., University of California, Berkeley
1978, Assistant Professor., University of British Columbia
1983, Associate Professor., UBC
1986, Professor., Department of Microbiology, UBC
2016--present., Killam Professor, UBC
Honors
1987, Canadian Society of Microbiologists Award
1994, Fellow of the Royal Society of Canada
2000, Jacob Biely Faculty Research Prize, (UBC’s top research award)
2002, Fellow of the American Academy of Microbiology
2005, Fellow of the Infectious Diseases Society of America
2007, Killam Prize (Canada Council’s prize for Health Research)
2009, Order of British Columbia (BC’s highest honour)
2011, Fellow, Canadian Academy of Health Sciences
2012, Prix Galien (Highest Award for Canadian Pharmaceutical
Research and Innovation)
Abstract
The inexorable increase in multidrug resistant infections combined with a decrease in new antibiotic discovery and the lack of compounds to treat recalcitrant infections is creating a potential crisis in human medicine. Thus it is imperative to consider alternatives to conventional antibiotics. Cationic host defense peptides are a key component of innate immunity and have multiple mechanisms that enable them to deal with infections and inflammation including an ability to favourably modulate the innate immune system, and distinct antibiotic and anti-biofilm activities.
It was demonstrated that Cationic host defense peptides(HDPs) boost protective innate immunity while suppressing potentially harmful inflammation/sepsis, and work synergistically with conventional therapies. The manipulation of natural innate immunity represents a new adjunctive therapeutic strategy against antibiotic-resistant infections. The lecture will demonstrate recent progress about a class of peptides based on HDPs that act against biofilms formed by multiple species of bacteria in a manner that is independent of activity vs. planktonic bacteria.