第395次SKLBE 学术论坛

以下为第395次SKLBE 学术论坛信息，请阅。

   报告题目： A nature-inspired novel anti-biofilm agent for enhanced biofilm mitigation

    报告人：美国俄亥俄大学顾停月教授

    地点：实验18楼315室

    时间：2018-1-16  10:00-11:30

   主持人： 张旭副教授

摘要：

Microbial biofilms cause biocorrosion and biofouling. They are also a major problem in the medical field. Biofilms are notoriously far more difficult to treat than planktonic cells in the bulk liquid because biofilms have various smart defense mechanisms against antimicrobial agents. Sessile cells usually require 10 times or higher concentrations of antimicrobials to treat than planktonic cells. This talk presents a very interesting bioinformatics discovery of an anti-biofilm peptide by mimicking a highly preserved peptide structure in some animals and plants that possess biofilm-free exteriors. Unlike its parent protein (equinatoxin II in sea anemone), the artificially engineered peptide exhibits no antimicrobial ability, but is capable of biofilm dispersal, especially when assisted by an antimicrobial stress. Experimental data indicate that at ppb levels this peptide is effective. It can enhance biofilm treatment by an extra 1-log or 2-log reduction of sessile cells. This nature-inspired thermostable 14-mer peptide can be economically produced via chemical synthesis or biosynthesis (fermentation), making it far more practical than its parent protein. This non-antimicrobial biofilm dispersal agent will also likely become a useful tool in microbiome research.

简介：

Prof. Tingyue Gu obtained his B.S. degree in Chemical Engineering from Zhejiang University in 1985. He earned a Ph.D. degree in Chemical Engineering from Purdue University in 1990. He worked as a postdoctoral biotechnologist for Miller Brewing Company in Milwaukee, Wisconsin for one year before joining Ohio University in 1992, where he is currently a full professor in the Department of Chemical and Biomolecular Engineering. He is also a lecture professor at Nankai University and “111 Plan” honorary professor at University of Science and Technology Beijing. He is a top expert on liquid chromatography modeling and simulation with a monograph published on the subject. He is a leader in biocorrosion research who developed several mechanisms, theories and the world’s first mechanistic biocorrosion prediction model. He has done grand rounds twice at the M. D. Anderson Cancer Center to talk about enhanced biofilm treatment methods.