SKLBE学术论坛
发布时间:2018-10-09 13:10:00
以下为第392次SKLBE 学术论坛信息,请阅。
报告题目:NAMPT-mediated NAD+ synthesis is essential for neuronal survival and motor function
时间:2018-1-8? 10:00-11:00
地点:实验18楼420会议室
报告人:Shinghua Ding, Ph.D., Associate professor of Bioengineering and the Investigator of Dalton Cardiovascular Research Center at University of Missouri-Columbia.
主持人:杨弋教授
摘要:
Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme of the salvage pathwayfor NAD+ biosynthesis. This presentation will discuss the role and mechanism of NAMPT neuronal death and motor function. In our study, we found that deletion of Nampt exacerbated neuronal death and brain damage after ischemia, while overexpression of Nampt has a protective effect against neuronal death after ischemia in mouse model.Furthermore, overexpression of Nampt can suppress mitochondrial dysfunction and impairment of mitochondrial biogenesis in ischemia. Using inducible and conditional knockout (cKO) mice, we found that specific deletion of theNamptin the projection neurons of adult mice leads toa progressive loss of body weight,motor neuron (MN) degeneration,motor function deficits, paralysis and eventually death. Mechanistically, Nampt deletion causes mitochondrial dysfunction and loss of mitochondrial homeostasis;Namptdeletion also causes muscle fiber type conversion, muscle atrophy, disruption of neuromuscular junction (NMJ) integrity and defective synaptic transmission at NMJs. When treated with nicotinamide mononucleotide (NMN), an immediate product of NAMPT, Nampt cKO mice exhibit significantly reduced motor function deficits and prolonged lifespan. Our studiesindicate that neuronal NAMPT plays an essential role in mitochondrial metabolic bioenergetics andneuronal survival in health and diseases.
简介:Dr. Ding graduated from Zhejiang University of Technology in 1986 and had his Ph.D degree at State University of New York at Buffalo in 1999. He followed with postdoctoral trainings first at Thomas Jefferson University (1999-2002) and later at University of Pennsylvania (2002-2005). His research mainly focuses on investigating and understanding the mechanisms of neuronal and brain protection, neural regeneration after ischemic stroke.