第337次SKLBE学术论坛（何远 博士，UIUC）

报告人：何 远  博士 

             美国密歇根大学

主持人： 刘琴 教授

报告人简介：

何远   美国密歇根大学

Department of Pathology and Immunology Program 

University of Michigan Medical School

1500 E Medical Center Dr., Rm 4111 CC

Ann Arbor, MI 48109

Education

1998    B. S., Biology, Nanchang University, Jiangxi, China

2001    M.S., Zoology, East China Normal University, Shanghai, China

2007    M.S., Microbiology, University of Illinois at Urbana-Champaign, IL, USA

2011    Ph.D., Cell and Developmental Biology, University of Illinois at Urbana-Champaign, IL, USA

Honors and awards

2015      Ruth L. Kirschstein National Research Service Award (USA)

2014      Ruth L. Kirschstein National Research Service Award (USA)

2009      Predoctoral Student Travel Award, American Society of Cell Biology (ASCB)

2007      John G. and Evelyn Hartman Heiligenstein Award for Outstanding Teaching Assistant in Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, 2007

1.     He Y., Zeng, M. Y. Yang D. Motro B. and Núñez G. Nek7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature. (Accepted 2016)

2.     Yang D., He Y., Muñoz-Planillo R., Liu Q. and Núñez G. Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock. Immunity. 2015 43(5) 923–932.

3.     Suzuki S, Franchi L, He Y, Munoz-Planillo R, Mimuro H, et al.. ShigellaType III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkcd. PLoS Pathog 2014 10(2): e1003926. doi:10.1371/journal.ppat.1003926

4.     Byrne M., Kimura Y., Kapoor A., He Y., Mattam K., Hasan K., Olson L., Wang F., Kenis P., Rao C.V. Oscillatory Behavior of Neutrophils Under Opposing Chemoattractant Gradients Supports a Winner-Take-All Mechanism. PLoS One., 2014 Jan 21;9(1):e85726

5.     He Y, Varadarajan S, Muñoz-Planillo R, Burberry A, Nakamura Y and Núñez G. 3,4-Methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome. J Biol Chem. 2014 Jan 10;289(2):1142-50.

6.     He, Y., Li, D., Cook, S., Yoon, M., Kapoor, A., Rao, C. V., Kenis, P., Chen, J. and Wang, F. Mammalian Target of Rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and actin polymerization. Mol Biol Cell. 2013 Nov;24(21):3369-80.

7.     He, Y., Franchi, L., Núñez, G. The Protein Kinase PKR is Critical for LPS-Induced iNOS Production, but Dispensable for Inflammasome Activation in Macrophages. Eur J Immunol. 2013 May;43(5):1147-52.

8.     He, Y., Franchi, L., Núñez, G. TLR Agonists Stimulate Nlrp3-Dependent IL-1β Production Independently of the Purinergic P2X7 Receptor in Dendritic Cells and In Vivo. J Immunol. 2013 Jan 1;190 (1):334-9.

9.     He, Y., Kapoor, A., Cook, S., Liu, S., Xiang, Y., Rao, C. V., Kenis, P., and Wang, F. The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL/C3G complex to and activating Rap1 at the leading edge. J Cell Science, 2011 124, 2153-2164.