第355次SKLBE学术论坛（Professor Patrick Fickers University of Liege, Belgium）

题    目：The Yeast Yarrowia lipolytica As a Cell-factory for the Synthesis of Added Value Chemicals

报告人：Professor Patrick Fickers

时    间:  2017-6-1（周四）  9:00-10:00

主持人： 花强 教授

 

报告人简介：

Professor Patrick Fickers has completed a Ph.D. in Biochemistry from University of Liège (Belgium). After a postdoc at Polytech’Lille (France), he joined in 2005 the Centre of Protein Engineering (Liège, Belgium) as a FNRS fellow. Form 2009 to 2014, he was an Associated Professor at Université libre de Bruxelles and the head of the Biotechnology and Bioprocess Unit. Since 2015, he is a Professor at Gembloux Agro BioTech, University of Liege, at TERRA Research and Teaching center. He has published more than 75 conferences proceedings,  50 research papers in peer-reviewed journals, 6 book chapters, one patents and two patent applications. His researches focus on the development of yeast strains by metabolic engineering and on process development in bioreactor for the production of compounds of biotechnological interest.

报告摘要：

Y. lipolytica is a non-conventional yeast, well-known for its unusual metabolic properties. Based on its ability to secrete high amounts of proteins and metabolites of biotechnological interest, Y. lipolytica has several industrial applications, including heterologous protein synthesis or citric acid production. The purpose of this seminar is to report on strain development for the synthesis of erythritol and erythrulose. Erythritol is a four-carbon sugar alcohol with application as food additive due to its sweetening properties. Erythrulose is a derivative of erythritol and is an intermediate of its catabolism. It has application as sunless tanning agent and as precursor for the synthesis of different drugs. By overexpressing gene GUT1 and TKL1, which encode a glycerol kinase and a transketolase, respectively, strain-overproducing erythritol were obtained. Erythrulose producing strain was obtained by deleting gene YALI0F01606g than code for an erythrulose kinase.