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Wei Wang

CreatedTime:2020-09-08 11:09:00


Wei Wang, Ph.D, Professor                                                                                                     



Research Interests

The long-term goal of his research is to discover and develop filamentous fungi chasis for heterologous proteins and microbial natural products production.

ØArtificial transcriptional activators design
ØSeeking new transcriptional regulators and regulation mechanism for cellulase.
ØTrichoderma reesei hyper-cellulolytic mutants construction


Selected Publications

1.  Chuan Wu, Yumeng Chen, Yifei Qiu, Xiao Niu, Ningjian Zhu, Jiehui Chen, Hong Yao, Wei Wang*, Yushu Ma*, A simple approach to mediate genome editing in the filamentous fungus Trichoderma reesei by CRISPR/Cas9-coupled in vivo gRNA transcription. Biotechnology Letters, 2020, 42(7):1203-1210.

2. Yumeng Chen1, Chuan Wu, Xingjia Fan, Xinqing Zhao, Xihua Zhao, Tao Shen, Dongzhi Wei, Wei Wang*, Engineering of Trichoderma reesei for enhanced degradation of lignocellulosic biomass by truncation of the cellulase activator ACE3. Biotechnology for Biofuels, 2020, 13:62.

3. Jiajia Zhang, Yumeng Chen, Chuan Wu, Pei Liu, Wei Wang*, Dongzhi Wei*, The transcription factor ACE3 controls cellulase activities and lactose metabolism via two additional regulators in the fungus Trichoderma reesei. Journal of Biological Chemistry, 2019, 294:18435-18450.

4.    Pei Liu, Guoxiu Zhang, Yumeng Chen, Jian Zhao, Wei Wang*, Dongzhi Wei, Enhanced cellulase production by decreasing intercellular pH through H+-ATPase gene deletion in Trichoderma reesei RUT-C30. Biotechnology for Biofuels, 2019, 12:195.

5.    Pei Liu, Aibo Lin, Guoxiu Zhang, Jiajia Zhang, Yumeng Chen, Tao Shen, Jian Zhao, Dongzhi Wei, Wei Wang*, Enhancement of cellulase production in Trichoderma reesei RUT-C30 by comparative genomic screening. Microbial Cell Factories, 2019, 18:81.

6.  Yumeng Chen, Chuan Wu, Yaling Shen, Yushu Ma, Dongzhi Wei, Wei Wang*, N,N-dimethylformamide induces cellulase production in the filamentous fungus Trichoderma reesei. Biotechnology for Biofuels, 2019, 12:36.

7.  Yumeng Chen, Yaling Shen, Wei Wang*, Dongzhi Wei*, Mn2+ modulates the expression of cellulase genes in Trichoderma reesei Rut-C30 via calcium signaling. Biotechnology for Biofuels, 2018, 11:54.

8.  Jiajia Zhang, Guoxiu Zhang, Wei Wang, Wei Wang*, Dongzhi Wei. Enhanced cellulase production in Trichoderma reesei RUT C30 via constitution of minimal transcriptional activators. Microbial Cell Factories, 2018, 17:75.

9.  Wei Wang#, Yumeng Chen, Dongzhi Wei*, Copper-mediated on-off control of gene expression in filamentous fungus Trichoderma reesei, Journal of Microbiological Methods, 2017, 143:63–65.

10.  Lei Zhang, Xihua Zhao, Guoxiu Zhang, Jiajia Zhang, Xuedong Wang, Suping Zhang, Wei Wang*, Dongzhi Wei*, Light-inducible genetic engineering and control of non-homologous end-joining in industrial eukaryotic microorganisms: LML 3.0 and OFN 1.0. Scientific Reports, 2016, 6:20761.

11.  Guoxiu Zhang, Pei Liu, Lei Zhang, Wei Wei, Xuedong Wang, Dongzhi Wei, Wei Wang*. Bioprospecting metagenomics of a microbial community on cotton degradation: Mining for new glycoside hydrolases. Journal of Biotechnology, 2016, 234:35-42.

12.  Guoxiu Zhang, Pei Liu, Wei Wei, Xuedong Wang, Dongzhi Wei, Wei Wang*. A light-switchable bidirectional expression system in filamentous fungus Trichoderma reesei. Journal of Biotechnology, 2016, 240:85-93.

13.  Pei Liu, Wei Wang*, Dongzhi Wei, Use of transcription activator-like effector for efficient gene modification and transcription in the filamentous fungus Trichoderma reesei. Journal of Industrial Microbiology &Biotechnology, 2017, 44:1367-1373.

14.  Liang Min, Lei Zhang, Xin Jiang, Wei Wei, Dongzhi Wei, Wei Wang*, A new strategy for the enzymatic degradation of sudan dyes in non-alkaline conditions, Water Air Soil Pollut, 2016, 227:200.

15.  Lei Zhang, Suping Zhang, Xin Jiang, Wei Wei, Wei Wang*, Dongzhi Wei, A novel host-vector system for heterologous protein co-expression and purification in the Trichoderma reesei industrial strain RUT-C30, Biotechnology Letters, 2016, 38:89–96.




Education

  1997.09- 2000.07  Ph.D.  China Agriculture University, Beijing, China.

  1989.09-1992.12  M.S.  North East Agriculture University,Haerbin,China.

  1982.09- 1986.07  B.S.  North East Agriculture University,Haerbin,China.

 

Professional experience

2002.02 -        Professor,School of Biotechnology, State Key Lab of Bioreactor Engineering, East China University of Sciences & Technology 

1986.07-2002.01  Associate professor, The head of department of Plant Pathology, North East Agriculture University


Contact information

State Key Laboratory of Bioreactor Engineering

School of Bioengineering

East China University of Science and Technology

130 Meilong Road, Shanghai, 200237, CHINA

Tel: 0086-21-64253707

E-mail: weiwang@ecust.edu.cn