Yunpeng Bai

Yunpeng Bai

Introduction

     Dr.Bai had graduated from Department of Chemical Engineering, Tsinghua University with a Bachelor degree on polymer science and engineering in 2004, and obtained his Master Degree from Department of Chemistry, Tsinghua University in 2007. He studied droplet microfluidics under the supervision of Professor Wilhelm Huck and obtained Ph.D. from Department of Chemistry, University of Cambridge in 2011. From 2012 to 2014, Dr. Bai did postdoctoral research in Professor Helene Andersson-Svahn’s proteomics group at Royal Institute of Technology, Stockholm, Sweden. He joined State Key Laboratory of Bioreactor Engineering, School of Biotechnology, ECUST on October 2014 with research interest in high-throughput screening based biocatalysis. He was selected in Shanghai Pujiang Program in 2015, and currently is supported by several grants including the National Natural Science Foundation, Shanghai Pujiang Program, the Fundamental Research Funds for the Central Universities, Young Scholars Incubation Program.

Research

? High-throughput screening based novel biocatalyst discovery and engineering

? Light-driven enzyme catalyzed asymmetry reduction

? Droplet microfluidics for strain development

Publication

2015：

14.  Huang, M.T.; Bai, Y.P.(Co-first Autor); Sjostrom, S.L.; Hallström, B.M.; Liu, Z.H.; Petranovic, D.; Uhlén, M.; Joensson, H.N.; Andersson-Svahn, H.; Nielsen, J.*, Microfluidic screening and whole-genome sequencing identifies mutations associated with improved protein secretion by yeast. Proc. Natl. Acad. Sci. USA, 2015, 112(34): 4689-4696.

13. Fan, C.W.; Xu, G.C.; Ma, B.D.; Bai, Y.P.; Zhang, J.; Xu, J.H.*, A novel d-mandelate dehydrogenase used in three-enzyme cascade reaction for highly efficient synthesis of non-natural chiral amino acids. Journal of Biotechnology, 2015, 195: 67-71.

12.  Liu, J.Y.; Bian, H.P.; Tang, Y.; Bai, Y.P.; Xu, J.H.*, Double substituted variant of Bacillus amyloliquefaciens esterase with enhanced enantioselectivity and high activity towards 1-(3’,4’-methylenedioxyphenyl)ethyl acetate. Applied Microbiology and Biotechnology, 2015, 99 (4): 1701-1708.

2014：

11. Sjostrom, S. L.; Bai, Y. P.; Huang, M. T.; Liu, Z. H.; Nielsen, J.; Joensson, H. N.; Andersson-Svahn, H.*, High-throughput screening for industrial enzyme production hosts by droplet microfluidics. Lab on a Chip, 2014, 14, 806-813.

10. Bai, Y. P.; Weibull, E.; Joensson, H. N.; Andersson-Svahn, H.*, Interfacing picoliter droplet microfluidics with addressable microliter compartments using fluorescence activated cell sorting. Sensors and Actuators B-Chemistry, 2014, 194, 249-254.

2006-2013：

9. Bai, Y. P.; Patil, S. N.; Bowden, S. D.; Poulter, S.; Pan, J.; Salmond, G. P. C.; Welch, M.; Huck, W. T. S.; Abell, C.*, Intra-Species Bacterial Quorum Sensing Studied at Single Cell Level in a Double Droplet Trapping System. International Journal of Molecular Sciences,2013, 14, (5), 10570-10581.

8. Ma, S. H.; Thiele, J.; Liu, X.; Bai, Y. P.; Abell, C.; Huck, W. T. S.*, Fabrication of Microgel Particles with Complex Shape via Selective Polymerization of Aqueous Two-Phase Systems. Small, 2012, 8, (15), 2356-2360.

7. Patil, S. N.; Shim, J. U.; Hodjkinson, J.; Abell, C.; Welch, M.; Bai, Y. P.; Huck, W.*, Microdroplet Technology: Study of Quorum Sensing in Bacteria. Abstracts of Papers of the American Chemical Society,2010, 239.

6. Bai, Y. P.; He, X. M.; Liu, D. S.; Patil, S. N.; Bratton, D.; Huebner, A.; Hollfelder, F.; Abell, C.; Huck, W. T. S.*, A double droplet trap system for studying mass transport across a droplet-droplet interface. Lab on a Chip,2010, 10, (10), 1281-1285.

5. Wang, M.; Comrie, J. E.; Bai, Y. P.; He, X. M.; Guo, S. Y.; Huck, W. T. S.*, Formation of Hierarchically Structured Thin Films. Advanced Functional Materials,2009, 19, (14), 2236-2243.

4. Chang, Y.; Bai, Y. P.; Teng, B.; Li, Z. L.*, A new drug carrier: Magnetite nanoparticles coated with amphiphilic block copolymer. Chinese Science Bulletin,2009, 54, (7), 1190-1196.

3. Teng, B.; Bai, Y. P.; Chang, Y.; Chen, S.; Li, Z.L.*, Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging. Bioorganic & Medicinal Chemistry Letters,2007, 17, (12), 3440-4.

2. Bai, Y. P.; Teng, B.; Chen, S. H.; Chang, Y.; Li, Z. L.*, Preparation of magnetite nanoparticles coated with an amphiphilic block copolymer: A potential drug carrier with a core-shell-corona structure for hydrophobic drug delivery. Macromolecular Rapid Communications,2006, 27, (24), 2107-2112.

1. Chen, S. Z.; Bai, Y. P.; Li, Z. L.*, Redox polymerization of methyl methacrylate in the fluorous triphasic system. Chinese Chemical Letters, 2006, 17, (2), 258-260.

Grants

1. National Natural Science Foundation, 21505044, 2016.01-2018.12.

2. Shanghai Pujiang Program, 15PJ1401200, 2015.07-2017.07.

3. Young Scholars Incubation Program，2015.07-2017.07.

4. The Fundamental Research Funds for the Central Universities, 222201414039, 2014.09-2016.09,

Awards

? 2015 Shanghai Pujiang Program

? 2015  Young Scholars Incubation Program

? 2011  Melville Lab Scholarship

? 2006  Dong Gang Scholarship, First Class, Tsinghua University

Address

Phone: 0086-21-64250840

Fax: 0086-21064250840

Email: ybai@ecust.edu.cn