Xuedong Wang

 

Wang Xuedong

PhD, Associate Professor, East China University of Science and Technology, State Key Lab of Bioreactor Engineering

      Dr. Wang received his PhD in Biochemical Engineering in 2002 from East China University of Science and Technology. Thereafter, he took a research scientist position with ECUST. In 2012, he went to GT, US, and worked in Reach Chen’s group as a visiting scholar for one year. He is currently an associate professor in the School of Biotechnology of ECUST. Dr. Wang has broad interests in metabolic engineering and biocatalysis. His research works are related to the R&D of biotech drugs.

Research Interests:

1. Metabolic Engineering: Metabolic pathway engineering and processing development

2. Biocatalysis and Biotransformation: Screening, preparation and characterization of new enzymes; Bioprocess development;

Research Funds:

Key Project of the National High Technology Research and Development Program of China 863（No.2009ZX09306-001）

Key Project of the National High Technology Research and Development Program of China 863( 2011AA02A213)

National Natural Science Foundation of China (General Program, 2013, No. 21276083；31570079)

Publications:

1. Xu tao，Zhang Lujia, Su Erzheng, Cui Dongbing, Wang Xuedong, Wei Dongzhi （2010）Disparity in productive binding mode of the slow-reacting enantiomer determines the novel catalytic behavior of Candida antarctica lipase B, Journal of Molecular Catalysis B: Enzymatic 62 (2010) 288–296

2. Wang Hengwei, Cheng Hairong, Wang Fengqing, Wei Dongzhi, Wang Xuedong  (2010) An improved 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction assay for evaluating the viability of Escherichia coli cells, Journal of Microbiological Methods 82:330–333

3. Zhang Jianguo, Wang Xuedong, Shen Danhong (2011) Efficient conversion from polysialogangliosides to monosialotetrahexosylganglioside using Oerskovia xanthineolytica YZ-2 2010 Bioprocess Biosyst Eng 34, (4): 493

4. Yang Chunsheng, Wang Xuedong, Wei Dongzhi (2011) A New Nitrilase-Producing Strain Named Rhodobacter sphaeroides LHS-305: Biocatalytic Characterization and Substrate Specificity Applied Biochemistry and Biotechnology 16(7): 1556-1567

5. Wang Hualei, Li Guinan1, Li Mingyang, Wei Dongzhi; Wang Xuedong (2014) A novel nitrilase from Rhodobacter sphaeroides LHS-305 cloning, heterologous expression and biochemical characterization World J Microbiol Biotechnol 30(1):245-52

6. Li Mingyang, Wang Xuedong （2014） The influence of hydroxypropyl-β-cyclodextrin on the enantioselective hydrolysis of 2-amino phenylpropionitrile catalyzed by recombinant nitrilase Bioresources and Bioprocessing 1:4

7. Gao Xingqiang, Feng Jianxun, Hua Qiang, Wei Dongzhi, Wang Xuedong (2014) Investigation of factors affecting biotransformation of phytosterols to 9-hydroxyandrost-4-ene-3, 17-dione based on the HP-β-CD-resting cells reaction system Biocatalysis and Biotransformation 32: 343–347

8. Xu Xinwei, Gao Xingqiang, Feng Jianxun, Wang Xuedong, Wei Dongzhi (2015) In?uence of temperature on nucleus degradation of 4-androstene-3,17-dione in phytosterol biotransformation by Mycobacterium Letters in Applied Microbiology 61: 63—68

9. Wang Hualei, Gao Wenyuan, Sun Huihui, Chen Lifeng, Zhang Lujia, Wang Xuedong, Wei Dongzhi （2015）Protein Engineering of a Nitrilase from Burkholderia cenocepacia J2315 for Efficient and Enantioselective Production of (R)-o-Chloromandelic Acid Applied and Environmental Microbiology 81（24）：8469

10.Yao Meiling, Zhang Jianguo, Wang Xuedong (2015) High-level secretion of human bikunin from recombinant Pichia pastoris Letters in Applied Microbiology 61: 63—68

11.Gao Xingqiang, Feng Jianxun, Hua Qiang, Wang Xuedong, Wei Dongzhi (2015) Enhanced steroid metabolites production by resting cell phytosterol bioconversion Chem. Biochem. Eng. Q., 29 (4): 343

Contact

Email: xdwang@ecust.edu.cn