Hexin Xie

Ph.D. Professor

Telephone：021-64252269

Email: xiehexin@ecust.edu.cn

Office：130 Meilong Rd., Research Building 14, Rm. 501

Education:

Ph.D. Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, USA. 2003-2008

B.S.  Department of Chemistry, Fudan University, Shanghai, China 1994-1998

Research Experience:

Since 2013 Professor,School of Pharmacy, East China University of Science and Technology

2008-2012  Postdoc, School of Medicine, Stanford University, USA

1998-2003  Research Assistant, Shanghai Institute of Organic Chemistry,

Research Interests:

Chemical biology, molecular imaging, Synthetic/Medicinal Chemistry

Publications:

1. Cheng, Y. #; Xie, H.#; Sule, P.; Hassounah, H.; Graviss, E. A.; Kong, Y.; Cirillo, J. D. and Rao, J.* “Fluorogenic Probes with Substitutions at the 2 and 7 Positions of Cephalosporin are Highly BlaC-Specific for Rapid Mycobacterium Tuberculosis Detection” Angew. Chem. Int. Ed.,2014, 53, 9360.(Reported by “Cheap test slashes time taken to diagnose TB”, Nature  doi: 10.1038/nature.2014.15503) .

2.  Xie, H. #, Mire, J. #, Kong, Y. #, Chang, M., Hassounah, H., Thornton, C.N., Sacchettini, J. C., Cirillo, J. D., Rao, J.* "Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe ", Nature. Chem.2012, 4, 802.(Reported by Nature(doi:10.1038/nature.2012. 11327) and Scientific American).

3. Xie, H.; Zhang, Y.; Zhang, S.; Chen, X.* "Bifunctional Cinchona Alkaloid Thiourea Catalyzed Highly Efficient, Enantioselective Aza-Henry Reaction of Cyclic Trifluoromethyl Ketimines: Synthesis of Anti-HIV Drug DPC 083" Angew. Chem. Int. Ed.,2011,50, 11773.  

4. Zhang, S.-L. #,Xie, H. #; Zhu, J.; Li, H.; Zhang, X.-S.; Li, J.*, “Organocatalytic enantioselective β-functionalization of aldehydes by oxidation of enamines and their application in cascade reactions” Nature. Commun. 2011, 2, 211-218. (Reported by C&E News (2011, 89(10), 9), ChemCatChem(2012, 4, 612) and Synfacts(2011, 5, 0560))

5. Xie, H.; Zu, L.; Li, H.; Wang, J.* “Organocatalytic Enantioselective Cascade Michael-Alkylation Reactions: Synthesis of Chiral Cyclopropanes and Investigation of Unexpected Organocatalyzed Stereoselective Ring Opening of Cyclopropanes”,J. Am. Chem. Soc., 2007, 129, 10886.