Lixin Zhang

Lixin Zhang, Ph.D., Professor

Room 201, Research Building 18

State Key Laboratory of Bioreactor Engineering (SKLBE)

130 Meilong Road,Shanghai, 200237,China

Phone: 021-64252575

Email: lxzhang@ecust.edu.cn 

URL: http://zhanglab.caspmi.cn/

http://sourcedb.im.cas.cn/english/zjrck/fs/201007/t20100720_2907800.html

Education 

    1990-1994    Ph.D. Microbiology, Institute of Applied Ecology, Chinese Academy of Sciences

    1986-1990    B.S. Microbiology, Shandong University, China

Research Experience and Achievements

    East China University of Science & Technology, Shanghai, China

        2016 July - present, State Key Laboratory of Bioreactor Engineering, Full Professor

    Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

        2006 May – 2016 June

        Deputy Director of CAS Key Laboratory of Pathogenic Microbiology &Immunology

        Inaugural Director of Drug Discovery Center for Tuberculosis

        Director and Full Professor, Center of Microbial Natural Product HTS Taxonomy-guided Screening

    Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, China

        2004 Jan. – 2006 April, Full Professor and Head for Laboratory of Marine Microbial Natural Products

        Editors-in-Chief with Prof. Arnold L. Demain, " Natural Products: Drug Discovery and Therapeutic Medicine ", Humana Press, USA

    SynerZ Pharmaceuticals, Inc. Lexington, MA

        2004 Jan. – 2006, co-founder, President, started up a biotech company for synergistic drug discovery to combat serious and life-threatening diseases. Established a subsidiary in China

    Cetek, Inc. Marlborough, MA

        2001 Oct. - 2003 Dec. Section Head of Drug Discovery Leading multi-disciplinary teams to build a high quality library of microbial natural products for drug discovery

    Microbia, Inc. Cambridge, MA

        1999 Jan. - 2001 Oct. Founding Scientist II - Senior Scientist

Honors

    2014 Roche Chinese Young Investigator Awardee

    2012 National 973 Basic Research Award, China

    2011 Executive Board Member, The International Chemical Biology Society

    2011 National Distinguished Young Scientist Award, China

    2011 Excellent Award, "One-Hundred Talent Program" Final Evaluation, Chinese Academy of Sciences

    2011 Excellent Supervisor Award, Chinese Academy of Sciences

    2011 Sponsored research grant from TB Global Alliances and Gates Foundation

    2010 Outstanding mentorship Awards, Institute of Microbiology, Chinese Academy of Sciences

    2007 Excellent hundred talents, Chinese Academy of Sciences

    2007 Chinese Academy of Sciences K. C. Wong Awards

    2007 The New Centuary National ‘Bai Qian Wan’ Talent Project Award

    2006 NECINA Brown Rudnick Business Plan Contest Runner-up Awards

    Co-founder/President, World High Tech Society (WHTS)

    Asia Council Member and President, Society for Laboratory Automation and Screening (SLAS)

    Executive Board Member and president-elect, the International Chemical Biology Society (ICBS)

    Executive Board Member, International Symposium on the Biology of Actinomycetes (ISBA)

    Executive Board Member, the GIM (Genetics of Industrial Microorganisms) International Committee

    Honorary lifetime member, Sino-American Pharmaceutical Professional Association (SAPA)

    Member, American Society for Cell Biology (ASCB)

    Member, American Society for Industrial Microbiology (SIM)

    Member, American Society for Microbiology (ASM)

    Member, American Association for the Advancement of Science (AAAS)

    Member, American Chemical Society (ACS)

    Member, American Society for Biochemical and Molecular Biology (ASBMB)

Recent Publications

1.  Wupeng Yan, Heng Song, Fuhang Song, Yisong Guo, Cheng-Hsuan Wu, Ampon Sae Her, Yi Pu, Shu Wang, Nathchar Naowarojna, Andrew Weitz, Michael P. Hendrich, Catherine E. Costello, Zhang L*, Pinghua Liu*, and Yan Jessie Zhang*. 2015. Endoperoxide Formation Catalyzed by FtmOx1, an α-Ketoglutarate-dependent Mononuclear Non-heme Iron Enzyme. Nature, 527, 539–543. 

2.  Bai C, Zhang Y, Zhao X, Hu Y, Xiang S, Miao J, Lou C*, Zhang L*. 2015. Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products in Streptomyces. Proc Natl Acad Sci U S A. 112 (39), 12181-6. 

3.  Wang Qian, Song Fuhang, Xiao Xue, Huang Pei, Li Li, Aaron Monte, Wael M. Abdel-Mageed, Wang Jian, Guo Hui, He Wenni, Xie Feng, Dai Huanqin, Liu Miaomiao, Chen Caixia, Xu Hao, Liu Mei, Andrew M. Piggott, Liu Xueting*, Robert J. Capon*, Zhang Lixin*. Abyssomicins from the South China Sea deep-sea sediment Verrucosispora sp.: Natural thioether Michael addition adducts as antitubercular prodrugs. Angew. Chem.-Int. Edit. 2013, 52, 1231-1234. 

4.  Zhuo Ying, Zhang Wenquan, Chen Difei, Gao Hong, Tao Jun, Liu Mei, Gou Zhongxuan, Zhou Xianlong, Ye Bangce, Zhang Qing, Zhang Siliang, Zhang Lixin*. Reversebiological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis, Proc. Natl. Acad. Sci. U S A, 2010,107(25), 11250-11254. 

5.  Ashforth Elizabeth Jane, Fu Chengzhang, Liu Xiangyang, Dai Huanqin, Song Fuhang, Guo Hui, Zhang Lixin*.  Bioprospecting for antituberculosis leads from microbial metabolites. Nat Prod Rep. 2010, 27, 1709-1719. 

6.  Zhang Lixin*, Yan Kezhi, Zhang Yu et al. High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Proc Natl Acad Sci U S A, 2007, 104(11), 4606-4611.