Yuzheng Zhao

Yuzheng Zhao  

Distinguished Research Fellow, Ph.D. Supervisor. Dr. Zhao received his bachelor degree in 2007 from Shandong University and his Ph.D. degree in 2012 from East China University of Science and Technology. He successively held the posts of lecture and associate professor at ECUST from 2012 to 2016. Since April 2016, he worked at ECUST as a Distinguished Research Fellow. Currently he is the member of State Key Laboratory of Bioreactor Engineering, and serves on editorial board of SRL Biotechnology & Bioengineering, SM Journal of Bioinformatics and Proteomics, Genetic Engineering and Gene Cloning: OpenAccess. Over the past five years, Dr. Zhao received many awards including Lift Engineering for Young Talent of China Association for Science and Technology in 2015, Shanghai Sailing Program in 2015, ECUST Outstanding Youth in 2015, Mayor of Shanghai Award for Youth Science and Technology Invention in 2013, The Excellent Doctoral Dissertation of Shanghai Municipality in 2013, Young Scientist Program-Travel Fellowship the 13th FAOBMB Congress in 2012, The Excellent PhD of Shanghai in 2012. He published more than 9 papers in Cell Metabolism, Nature Protocols, The EMBO Journal, Current Opinion in Biotechnology, and other peer-reviewed scientific journals, and applied 1 PCT patent and 5 Chinese invention patents.

Research Interests:

1. Metabolite biosensors for living cell and in vivo imaging

2. Drug discovery and development for metabolic diseases

3. Regulation mechanism of cell metabolism

Selected Publications:  

1. Zhao, Y., Wang, A., Zou, Y., Su, N., Loscalzo, J., and Yang, Y. In vivo monitoring of cellular energy metabolism using a highly responsive sensor for NAD+/NADH redox state. Nature Protocols, 2016, In Press. (IF: 9.673)

2. Zhao, Y., Yang, Y. Real-time and high-throughput analysis of mitochondrial metabolic states in living cells using genetically encoded NAD+/NADH sensors. Free Radical Biology & Medicine, 2016, Invited review. (IF: 5.736)

3. Zhao, Y., Hu, Q., Cheng, F., Su, N., Wang, A., Zou, Y., Hu, H., Chen, X., Zhou, H.M., Huang, X., et al. SoNar, a Highly Responsive NAD(+)/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents. Cell Metabolism, 2015, 21(5): 777-789. (IF: 17.565)

4. Zhao, Y., Jin, J., Hu, Q., Zhou, H.M., Yi, J., Yu, Z., Xu, L., Wang, X., Yang, Y., and Loscalzo, J. Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metabolism, 2011, 14(4): 555-566. (IF: 17.565)

5. Zhao, Y., and Yang, Y. Profiling metabolic states with genetically encoded fluorescent biosensors for NADH. Current Opinion in Biotechnology, 2015, 31, 86-92. (IF: 7.117)

6. Wang, Y., Zhou, L., Zhao, Y., Wang, S., Chen, L., Liu, L., Ling, Z., Hu, F., Sun, Y., Zhang, J., et al. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. The EMBO Journal, 2014, 33: 1304–1320. (IF: 10.434)

7. Yang, H., Zhou, L., Shi, Q., Zhao, Y., Lin, H., Zhang, M., Zhao, S., Yang, Y., Ling, Z., Guan, K., et al. SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth. The EMBO Journal, 2015, 34:1110-1125. (IF: 10.434)

Book:

1. Zhao, Y., Yang, Y. Loscalzo, J. Real-Time Assessment of the Metabolic Profile of Living Cells with Genetically Encoded NADH Sensors. Methods in Enzymology, 2014, 542: 349-367. (ISBN：978-0-12-416618-9)

Contact:

Building 18, Room 733, 130 Meilong Road, Shanghai, China, 200237

Tel/Fax: 86-21-64251287

E-mail: yuzhengzhao@ecust.edu.cn