Gaowei Zheng

Gao-Wei Zheng

Associate professor, State Key Laboratory of Bioreactor Engineering, East China University of Science & Technology, Shanghai, P.R. China

Contact Information

Address: Meilong Road 130, Shanghai 200237, China

Office: Room 911, Researching Building 18

Phone /Fax: +86-21-64250840

Email: gaoweizheng@ecust.edu.cn

Professional Experience

? 2015.09-2016.09

University of Manchester, Manchester Institute of Biotechnology (MIB), Academic Visitor

? 2013.09-now

Full associate professor, East China University of Science & Technology, Shanghai, P. R. China

? 2011.09-2013.08

Assistant professor, East China University of Science & Technology, Shanghai, P. R. China

Education

? 2005.09-2010.08 Ph.D. Biochemical Engineering, East China University of Science & Technology, Shanghai, P. R. China

? 2001.09-2005.07 B.E. Biotechnology, Sichuan University, Chengdu, Sichuan, P. R. China

Research Interests

? Discovery of novel enzymes, and creation of tailor-made enzymes using directed evolution and rational protein design

? Synthesis of optically pure compounds by enzymes, e.g. for pharmaceutical applications

Publication

[1] Li H, Zhang GX, Li LM, Ou YS, Wang MY, Li CX, Gao-Wei Zheng,* Xu JH*. A novel (R)-imine reductase from Paenibacillus lactis for asymmetric reduction of 3H-indoles. ChemCatChem 2016, http://dx.doi.org/10.1002/cctc.201501170.

[2] Chen FF, Liu YY, GW Zheng*, Xu JH*. Asymmetric amination of sec-alcohols using a redox-neutral two-enzyme cascade. ChemCatChem, 2015, 7: 3838-3841. (Highlighted by Nature Chemistry 2015, 7, 948)

[3] Hao Li, Zheng-Jiao Luan, Gao-Wei Zheng,* and Jian-He Xu*. Efficient Synthesis of Chiral indolines using an Imine Reductase from Paenibacillus lactis. Adv Synth Catal, 2015, 357: 1692-1696.

[4] Zhang Yu-Jun, Zhang Wen-Xia, Gao-Wei Zheng,* and Jian-He Xu*. Identification of an ε-Ketoester Reductase for Efficient Synthesis of (R)-α-Lipoic Acid Precursor. Adv Synth Catal, 2015, 357: 1697-1702.

[5] Hieu-Huy Nguyen-Tran, Gao-Wei Zheng,* Xu-Hong Qian and Jian-He Xu*. Highly selective and controllable synthesis of arylhydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitroreductase BaNTR1. Chem Commun 50, 2861–2864, 2014.

[6] Jia-Yan Liu, Gao-Wei Zheng* and Jian-He Xu*. Improved enantioselective hydrolysis of 1-(3,4-methylenedioxyphenyl)ethyl acetate by a cold-adapted Bacillus amyloliquefaciens esterase. Biotechnol Bioprocess Eng accepted, 2014.

[7] Wei-Jia Zhou, Yan Ni, Gao-Wei Zheng*, Huan-Hui Chen, Zhi-Rong Zhu and Jian-He Xu*. Enzymatic resolution of a chiral chlorohydrin precursor for (R)-lipoic acid synthesis via lipase catalyzed enantioselective transacylation with vinyl acetate. J Mol Catal B-Enzym 10.1016/j.molcatb.2013.11.005, 2013.

[8] Gao-Wei Zheng, Xu-Yun Liu, Zhi-Jun Zhang, Ping Tian*, Guo-Qiang Lin and Jian-He Xu*. Separation of enantiopure m-substituted 1-phenylethanols in high space-time yield using Bacillus subtilis esterase. RSC Adv 3: 20446–20449, 2013.

[9] Jia-Yan Liu, Gao-Wei Zheng*, Chun-Xiu Li, Hui-Lei Yu, Jiang Pan, Jian-He Xu*. Multi-substrate fingerprinting of esterolytic enzymes with a group of acetylated alcohols and statistic analysis of substrate spectrum. J Mol Catal B-Enzym 89: 41-47, 2013.

[10] Minh-Thu Ngo-Thi, Jin-Gang Yin, Jiang Pan, Gao-Wei Zheng*, Jian-He Xu*. Enantioselective hydrolysis of dl-menthyl benzoate by cell-free extract of newly isolated Acinetobacter sp ECU2040．Appl Biochem Biotechnol 170(8): 1974-1981, 2013.

[11] Chen-Sheng Zhang, Zhi-Jun Zhang, Chun-Xiu Li, Hui-Lei Yu, Gao-Wei Zheng*, Jian-He Xu*. Efficient production of (R)-o-chloromandelic acid by deracemization of o-chloromandelonitrile with a new nitrilase mined from Labrenzia aggregate. Appl Microbiol Biotechnol 95: 91–99, 2012.

[12] Gao-Wei Zheng, Jian-He Xu*. New opportunities for biocatalysis: driving the synthesis of chiral chemicals. Curr Opin Biotechnol 22: 784–792, 2011.

[13] Gao-Wei Zheng, Hui-Lei Yu, Chun-Xiu Li, Jiang Pan, Jian-He Xu*. Immobilization of Bacillus subtilis esterase by simple cross-linking for enzymatic resolution of dl-menthyl acetate. J Mol Catal B-Enzym 70: 138?143, 2011.

[14] Xin Tian, Gao-Wei Zheng,* Chun-Xiu Li, Zhi-Long Wang, Jian-He Xu*. Enantioselective production of (S)-1-phenyl-1, 2-ethanediol from dicarboxyesters by recombinant Bacillus subtilis esterase. J Mol Catal B-Enzym 73 (1-4): 80–84, 2011.

[15] Gao-Wei Zheng, Jiang Pan, Hui-Lei Yu, Minh-Thu Ngo-Thi, Chun-Xiu Li, Jian-He Xu. An efficient bioprocess for enzymatic production of l-menthol with high ratio of substrate to catalyst using whole cells of recombinant E. coli. J Biotechnol 150 (1): 108?114, 2010.

[16] Gao-Wei Zheng, Hui-Lei Yu, Jian-Dong Zhang, Jian-He Xu. Enzymatic production of l-menthol by a high substrate concentration tolerable esterase from newly isolated Bacillus subtilis ECU0554. Adv Synth Catal 351: 405?414, 2009.