Mian Zhou

Mian Zhou

Associate Professor, State Key Laboratory of Bioreactor Engineering

Education and research experience:

2005-2009 B.S. in Biotechnology, School of Life Sciences, Nanjing University

2009-2014 Ph.D. in Department of Physiology, University of Texas Southwestern Medical Center at Dallas, worked on the role of non-optimal codon usage in regulating protein expression, structure and function. Findings were published on Nature, Molecular Microbiology, EMBO Reports and other journals.

Won the 2013 Chinese Government Award for Outstanding Self-financed Students Abroad (Presented by China Scholarship Council) and joined East China University of Science and Technology in Dec 2014.Supported by 2015 Shanghai Pujiang Program.

Research Interest:

1.       The mechanism and pathways involved in methanol induction and glucose/glycerol repression of AOX1 promoter in Pichia pastoris;

2.       Identify and study the key components and pathways involved in heterologous protein secretion and expression in Pichia pastoris.

Publication:

Zhou, M.,Guo, J., Cha, J., Chae, M., Chen S., Barral, J., Sachs, M.& Liu, Y. (2013)."Non-optimal codon usage affects expression, structure and function of clock protein FRQ." Nature 495(7439): 111-115.

Cha, J., Zhou, M., and Liu, Y. (2013). “CATP is a critical component of the Neurospora circadian clock by regulating the nucleosome occupancy rhythm at the frequency locus.” EMBO reports, 14(10): 923-930.

Cha, J., Zhou, M., and Liu, Y. (2015).“The mechanism of the Neurospora circadian clock, a frequency-centric view.” BIOCHEMISTRY, 54(2): 150-156.

Cha, J., Zhou, M., and Liu, Y. (2015).“Methods to Study Molecular Mechanisms of the NeurosporaCircadian Clock.” Methods in Enzymology, 551:137-151.

Zhou, M., Wang, T., Fu, J., Xiao, G. and Liu, Y. (2015).“Non-optimal codon usage influences protein structure in intrinsically disordered regions.”Molecular Microbiology, Accepted, Epub ahead of print.

Contact:

Address: School of Biotechnology, East China University of Science and Technology

130 Meilong Road, Shanghai, China 200237

Tel:021-64253065

Email: mianzhou@ecust.edu.cn