Yan Zhou

Zhou Yan  


Professor

School of biotechnology

State Key Laboratory of Bioreactor Engineering

East China University of Science and Technology, Shanghai, China.


Education and Employment:

2011-present professor, East China University of Science and Technology, School of biotechnology

2002-2011 Associate professor, East China University of Science and Technology, School of biotechnology

1997-2002 Research assistant, East China University of Science and Technology, School of biotechnology

1996-1997 Research assistant, City University of Hong Kong, Department of Biology and Chemistry

1991-1996 Research assistant, East China University of Science and Technology, School of biotechnology

1988-1991 Master degree, East China University of Chemical Technology, Department of Biochemical Engineering

1984-1988 Bachelor degree, East China University of Chemical Technology, Department of Biochemistry


Research Interests:

1. Animal cell culture technology and bioprocess development.

2. Expansion, differentiation and senescence of the stem cells in vitro.

3. Bioprocess and bioreactor engineering for tissue engineering.

4. Interactions between the cells and three-dimensional degradable matrices.


Recent Publications:

1. Xiao-Lei Shi, Yimeng Gao, Yupeng Yan, Hucheng Ma, Lulu Sun, Pengyu Huang, Xuan Ni, Ludi Zhang, Xin Zhao, Haozhen Ren, Dan Hu, Yan Zhou, Feng Tian, Yuan Ji, Xin Cheng, Guoyu Pan*, Yi-Tao Ding*, Lijian Hui*. Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes. Cell Research. 2016; 26(2):206-216.

2. Yingdi Zhao, Ke Tan, Yan Zhou, Zhaoyang Ye*, Wen-Song Tan. A combinatorial variation in surface chemistry and pore size of three-dimensional porous poly(?-caprolactone) scaffolds modulates the behaviors of mesenchymal stem cells. Materials Science and Engineering: C. 2016; 1(59): 193-202.

3. Yaya Liu, Weiyan Zhang, Xiancun Deng, Hong Fai Poon, Xuping Liu, Wen-Song Tan, Yan Zhou, Li Fan*. Chinese hamster ovary cell performance enhanced by a rational divide-and conquer strategy for chemically defined medium development. Journal of Bioscience and Bioengineering. 2015; 120(6): 690-696.

4. Lei Xu, Zhaoyang Ye*, Yan Zhou and Wen-Song Tan. Towards engineering complex tissue/organs: a coculture perspective. Austin Journal of Biomedical Engineering. 2015; 2(1): 1028-1029.

5. Min Chen, Yi Zhang, Yan Zhou, Yan Zhang, Meidong Lang, Zhaoyang Ye*, Wensong Tan*. Pendant small functional groups on poly(?-caprolactone) substrate modulate adhesion, proliferation and differentiation of human mesenchymal stem cells. Colloids and Surfaces B Biointerfaces. 2015; 134: 322-331.

6. Feiyue Xu, Lei Xu, Qi Wang, Yan Zhou, Zhaoyang Ye*, Wen-Song Tan*. A three-dimensional dynamic coculture system enabling facile cell separation for chondrogenesis of mesenchymal stem cells. Biochemical Engineering Journal, 2015; 15(103): 68-76.

7. Houyong Luo, Maiqin Chen, Xiu Wang, Yang Mei, Zhaoyang Ye*, Yan Zhou*, Wen-Song Tan. Fabrication of centimeter-sized viable 3D tissue constructs endowed with microchannel conduits for improved tissue properties through assembling of cell-laden microbeads. Journal of Tissue Engineering and Regenerative Medicine. 2014; 8: 493-504.

8. Xiu Wang, Qingling Jiao, Songjie Zhang, Zhaoyang Ye*, Yan Zhou*, Wen-Song Tan. Perfusion culture induced template-assisted assembling of cell-laden microcarriers is a promising route for fabricating macrotissues. Biotechnology Journal. 2014; 9: 1425-1434.

9. Maiqin Chen, Min Zhou, Zhaoyang Ye*, Yan Zhou*, Wen-Song Tan*. Ectopic osteogenesis of macroscopic tissue constructs assembled from human mesenchymal stem cell-laden microcarriers through In vitro perfusion culture. PLoS ONE. 2014; 9(10): e109214.

10. Yan Zhang*, Yi Zhang, Min Chen, Yan Zhou, Meidong Lang*. Galactosylated poly(ε-caprolactone) membrane promoted liver-specific functions of HepG2 cells in vitro. Materials Science and Engineering, C. 2014; 41: 52-58.

11. Feiyue Xu, Lei Xu, Qi Wang, Zhaoyang Ye*, Yan Zhou, Wen-Song Tan*. 3D dynamic culture of rabbit articular chondrocytes encapsulated in alginate gel beads using spinner flasks for cartilage tissue regeneration. BioMed Research International. 2014; 2014: 1-10.

12. Qingchun Zhang, Houyong Luo, Yan Zhang, Yan Zhou, Zhaoyang Ye*, Wensong Tan, Meidong Lang*. Fabrication of three-dimensional poly(ε-caprolactone) scaffolds with hierarchical pore structures for tissue engineering. Materials Science and Engineering C. 2013; 33: 2094-2103.

13. Lei Xu, Qi Wang, Feiyue Xu, Zhaoyang Ye*, Yan Zhou, Wen-Song Tan*. Mesenchymal stem cells downregulate articular chondrocyte differentiation in noncontact coculture systems: implications in cartilage tissue regeneration. Stem Cells and Development. 2013; 22(11): 1657-1669.

14. Ying Ma*, Ying Zhang, Shan Zhao, Yu Wang, Siran Wang, Yan Zhou, Na Li, Hongguo Xie, Weiting Yu, Yang Liu, Wei Wang, Xiaojun Ma*. Modeling and optimization of membrane preparation conditions of the alginate-based microcapsules with response surface methodology. Journal of Biomedical Materials Research Part A. 2012; 100A: 989-998.

15. Yi Zhang, Yan Zhang*, Min Chen, Jinliang Yan, Zhaoyang Ye, Yan Zhou, Wensong Tan,  Meidong Lang. Surface properties of amino-functionalized poly(ε-caprolactone) membranes and the improvement of human mesenchymal stem cell behavior. Journal of Colloid and Interface Science. 2012; 368, 64-69.

16. Fei Chen, Li Fan, Jiaqi Wang, Yan Zhou, Zhaoyang Ye, Liang Zhao*, Wensong Tan. Insight into the roles of hypoxanthine and thymidine on cultivating antibody-producing CHO cells: cell growth, antibody production and long-term stability. Applied Microbiology and Biotechnology. 2012; 93(1): 169-178.

17. Wei Wu, Zhaoyang Ye, Yan Zhou*, Wen-Song Tan. AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells. The International Journal of Artificial Organs. 2011; 34(12): 1128-1136

18. Maiqin Chen, Xiu Wang, Zhaoyang Ye, Yan Zhang, Yan Zhou*, Wen-Song Tan*. A modular approach to the engineering of centimeter-sized bone tissue constructs using human amniotic mesenchymal stem cells-laden microcarriers. Biomaterials. 2011; 32(30): 7532-7542.

19. Tianci Kou, Li Fan, Zhaoyang Ye, Yan Zhou, Xuping Liu, Liang Zhao*, Wensong Tan. Process analysis of reduced specific productivity of TNFR-Fc in chinese hamster ovary cells at high cell density. Process Biochemistry. 2011; 46: 1492-1499.

20. Zhaoyang Ye*, Yan Zhou, Haibo Cai, Wensong Tan. Myocardial regeneration: Roles of stem cells and hydrogels. Advanced Drug Delivery Reviews. 2011; 63: 688-697.

21. Yan Jinliang, Ye Zhaoyang*, Chen Min, Liu Zhanzhan, Xiao Yan, Zhang Yan, Zhou Yan, Tan Wen-song, Lang Meidong*. Fine tuning micellar core-forming block of poly(ethylene glycol)-block-poly(ε-caprolactone) amphiphilic copolymers based on chemical modification for the solubilization and delivery of doxorubicin. Biomacromolecules. 2011; 12(7): 2562-2572.

22. Yan Jinliang, Ye Zhaoyang*, Luo Houyong, Chen Min, Zhou Yan, Tan Wensong, Xiao Yan, Zhang Yan, Lang Meidong*. Synthesis, characterization, fluorescence labeling and cellular internalization of novel amine-functionalized poly(ethylene glycol)-block-poly (ε-caprolactone) amphiphilic block copolymers. Polymer Chemistry. 2011; 2: 1331-1340.

23. Tianci Kou, Li Fan, Zhaoyang Ye, Yan Zhou, Liang Zhao*, Wensong Tan*. Increasing the productivity of TNFR-Fc in GS-CHO cells at reduced culture temperature. Biotechnology and Bioprocess Engineering. 2011; 16: 136-143.

24. Fei Chen, Tianci Kou, Li Fan, Yan Zhou, Zhaoyang Ye, Liang Zhao*, Wensong Tan. The Combined Effect of Sodium Butyrate and Low Culture Temperature on the Production, Sialylation, Biological Activity of an Antibody Produced in CHO Cells. Biotechnology and Bioprocess Engineering. 2011; 16(6): 1157-1165.

25. Tianci Kou, Li Fan, Zhaoyang Ye, Yan Zhou, Xuping Liu, Liang Zhao*, Wensong Tan. Detailed understanding of enhanced specific productivity in chinese hamster ovary cells at low culture temperature. Journal of Bioscience and Bioengineering. 2011; 111(3): 365-369.

26. Min Wang, Yan Zhou*, Wen-Song Tan. Clonal isolation and characterization of mesenchymal stem cells from human amnion, Biotechnology and Bioprocess Engineering. 2010; 15(6): 1047-1058.

27. Yang Mei, Qiang Tang, Zhaoyang Ye, Yan Zhou*, Wen-Song Tan. Modulating and modeling aggregation of cell-seeded microcarriers in stirred culture system for macrotissue engineering, Journal of Biotechnology. 2010; 150(3): 438-446.

28. Li Fan, Liang Zhao, Zhaoyang Ye, Yating Sun, Tianci Kou, Yan Zhou, Wen-Song Tan*. Effect of culture temperature on TNFR-Fc productivity in recombinant glutamine synthetase chinese hamster ovary cells. Biotechnology Letters. 2010; 32(9): 1239-1244.


Corresponding address:

The State Key Laboratory of Bioreactor Engineering,

East China University of Science and Technology,

130 Meilong Road, P.O.Box 309, Shanghai 200237, P.R.China

E-mail: zhouyan@ecust.edu.cn

Fax: +86-21-64252250

Tel: +86-21-64251570